Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914962392> ?p ?o ?g. }
- W2914962392 endingPage "295" @default.
- W2914962392 startingPage "290" @default.
- W2914962392 abstract "Presentation of short peptides, produced through intracellular proteolysis, by MHC class I molecules (MHC-I) is the basis of adaptive immune surveillance and responses by cytolytic CD8+ T lymphocytes. In the principal pathway of peptide processing for MHC-I that operates in all nucleated cells, MHC-I-binding peptides are produced through stepwise proteolysis starting with source protein degradation by cytosolic proteasome complexes. Among the fraction of proteasome products reaching the lumen of the endoplasmic reticulum, a significant proportion is thought to have a length exceeding that adapted to MHC class I binding and requires N-terminal trimming. This is carried out by one murine and two human endoplasmic reticulum aminopeptidases, the ERAP enzymes. While the critical role of ERAP for producing a ligandome optimized for MHC-I is well documented, it remains unclear how this is mechanistically achieved. In this review, we will discuss the evidence supporting the alternative “MHC template” and “molecular ruler” models that have been proposed to explain how ERAP activity adapts to the ligand requirements of MHC-I. We will also review evidence for dimerization of the two human ERAP enzymes and its potential functional relevance." @default.
- W2914962392 created "2019-02-21" @default.
- W2914962392 creator A5038908541 @default.
- W2914962392 creator A5049711214 @default.
- W2914962392 date "2019-05-01" @default.
- W2914962392 modified "2023-10-01" @default.
- W2914962392 title "Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization" @default.
- W2914962392 cites W1534035172 @default.
- W2914962392 cites W1553877174 @default.
- W2914962392 cites W1608008200 @default.
- W2914962392 cites W1670212854 @default.
- W2914962392 cites W1775831845 @default.
- W2914962392 cites W1809576401 @default.
- W2914962392 cites W1848498255 @default.
- W2914962392 cites W1924947656 @default.
- W2914962392 cites W1964156630 @default.
- W2914962392 cites W1965569896 @default.
- W2914962392 cites W1967811409 @default.
- W2914962392 cites W1981338942 @default.
- W2914962392 cites W1992099618 @default.
- W2914962392 cites W1994633456 @default.
- W2914962392 cites W1995317534 @default.
- W2914962392 cites W1995448798 @default.
- W2914962392 cites W1997214801 @default.
- W2914962392 cites W2015416001 @default.
- W2914962392 cites W2018327543 @default.
- W2914962392 cites W2029774129 @default.
- W2914962392 cites W2033605807 @default.
- W2914962392 cites W2038371153 @default.
- W2914962392 cites W2042689290 @default.
- W2914962392 cites W2046579578 @default.
- W2914962392 cites W2050944927 @default.
- W2914962392 cites W2053054271 @default.
- W2914962392 cites W2062908727 @default.
- W2914962392 cites W2064081671 @default.
- W2914962392 cites W2067661858 @default.
- W2914962392 cites W2068514170 @default.
- W2914962392 cites W2077053248 @default.
- W2914962392 cites W2081764901 @default.
- W2914962392 cites W2095139077 @default.
- W2914962392 cites W2096809569 @default.
- W2914962392 cites W2097543113 @default.
- W2914962392 cites W2099580736 @default.
- W2914962392 cites W2102237050 @default.
- W2914962392 cites W2103832788 @default.
- W2914962392 cites W2105842551 @default.
- W2914962392 cites W2108007504 @default.
- W2914962392 cites W2108581833 @default.
- W2914962392 cites W2115730533 @default.
- W2914962392 cites W2118578633 @default.
- W2914962392 cites W2134802820 @default.
- W2914962392 cites W2139725489 @default.
- W2914962392 cites W2149805171 @default.
- W2914962392 cites W2153228313 @default.
- W2914962392 cites W2155755888 @default.
- W2914962392 cites W2159778991 @default.
- W2914962392 cites W2165126732 @default.
- W2914962392 cites W2167289460 @default.
- W2914962392 cites W2234915430 @default.
- W2914962392 cites W2517222404 @default.
- W2914962392 cites W2589593756 @default.
- W2914962392 cites W2764000439 @default.
- W2914962392 cites W2766881846 @default.
- W2914962392 cites W2794996863 @default.
- W2914962392 cites W2810881461 @default.
- W2914962392 cites W2899507676 @default.
- W2914962392 doi "https://doi.org/10.1016/j.humimm.2019.01.003" @default.
- W2914962392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30682405" @default.
- W2914962392 hasPublicationYear "2019" @default.
- W2914962392 type Work @default.
- W2914962392 sameAs 2914962392 @default.
- W2914962392 citedByCount "29" @default.
- W2914962392 countsByYear W29149623922019 @default.
- W2914962392 countsByYear W29149623922020 @default.
- W2914962392 countsByYear W29149623922021 @default.
- W2914962392 countsByYear W29149623922022 @default.
- W2914962392 countsByYear W29149623922023 @default.
- W2914962392 crossrefType "journal-article" @default.
- W2914962392 hasAuthorship W2914962392A5038908541 @default.
- W2914962392 hasAuthorship W2914962392A5049711214 @default.
- W2914962392 hasBestOaLocation W29149623921 @default.
- W2914962392 hasConcept C108249834 @default.
- W2914962392 hasConcept C139447449 @default.
- W2914962392 hasConcept C147483822 @default.
- W2914962392 hasConcept C154317977 @default.
- W2914962392 hasConcept C158617107 @default.
- W2914962392 hasConcept C158619295 @default.
- W2914962392 hasConcept C170627219 @default.
- W2914962392 hasConcept C181199279 @default.
- W2914962392 hasConcept C202751555 @default.
- W2914962392 hasConcept C203014093 @default.
- W2914962392 hasConcept C207936829 @default.
- W2914962392 hasConcept C2781307694 @default.
- W2914962392 hasConcept C55493867 @default.
- W2914962392 hasConcept C83464605 @default.
- W2914962392 hasConcept C86803240 @default.
- W2914962392 hasConcept C95444343 @default.
- W2914962392 hasConceptScore W2914962392C108249834 @default.