Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914970060> ?p ?o ?g. }
- W2914970060 abstract "As one of the three proteinogenic aromatic amino acids, l-phenylalanine is widely applied in the food, chemical and pharmaceutical industries, especially in production of the low-calorie sweetener aspartame. Microbial production of l-phenylalanine has become attractive as it possesses the advantages of environmental friendliness, low cost, and feedstock renewability. With the progress of metabolic engineering, systems biology and synthetic biology, production of l-phenylalanine from glucose in Escherichia coli with relatively high titer has been achieved by improving the intracellular levels of precursors, alleviating transcriptional repression and feedback inhibition of key enzymes, increasing the export of l-phenylalanine, engineering of global regulators, and overexpression of rate-limiting enzymes. In this review, successful metabolic engineering strategies for increasing l-phenylalanine accumulation from glucose in E. coli are described. In addition, perspectives for further improvement of production of l-phenylalanine are discussed." @default.
- W2914970060 created "2019-02-21" @default.
- W2914970060 creator A5001649087 @default.
- W2914970060 creator A5025437312 @default.
- W2914970060 creator A5069771802 @default.
- W2914970060 creator A5075284628 @default.
- W2914970060 date "2019-02-15" @default.
- W2914970060 modified "2023-10-14" @default.
- W2914970060 title "Metabolic engineering for the production of l-phenylalanine in Escherichia coli" @default.
- W2914970060 cites W1505372025 @default.
- W2914970060 cites W1507458182 @default.
- W2914970060 cites W1530152828 @default.
- W2914970060 cites W1550655865 @default.
- W2914970060 cites W1579596275 @default.
- W2914970060 cites W1585571745 @default.
- W2914970060 cites W1606165491 @default.
- W2914970060 cites W1755729588 @default.
- W2914970060 cites W1781805691 @default.
- W2914970060 cites W1783294467 @default.
- W2914970060 cites W1804685181 @default.
- W2914970060 cites W1942489888 @default.
- W2914970060 cites W1966307757 @default.
- W2914970060 cites W1972825567 @default.
- W2914970060 cites W1973244479 @default.
- W2914970060 cites W1982502487 @default.
- W2914970060 cites W1988923572 @default.
- W2914970060 cites W1995920416 @default.
- W2914970060 cites W1999466090 @default.
- W2914970060 cites W2004033922 @default.
- W2914970060 cites W2004660097 @default.
- W2914970060 cites W2005616487 @default.
- W2914970060 cites W2009642878 @default.
- W2914970060 cites W2011072729 @default.
- W2914970060 cites W2017429344 @default.
- W2914970060 cites W2026569578 @default.
- W2914970060 cites W2028170586 @default.
- W2914970060 cites W2031545031 @default.
- W2914970060 cites W2043604566 @default.
- W2914970060 cites W2044318184 @default.
- W2914970060 cites W2052857942 @default.
- W2914970060 cites W2061824151 @default.
- W2914970060 cites W2071622896 @default.
- W2914970060 cites W2080827205 @default.
- W2914970060 cites W2081750229 @default.
- W2914970060 cites W2083786160 @default.
- W2914970060 cites W2085796061 @default.
- W2914970060 cites W2091304959 @default.
- W2914970060 cites W2092173381 @default.
- W2914970060 cites W2092828064 @default.
- W2914970060 cites W2095033276 @default.
- W2914970060 cites W2095757667 @default.
- W2914970060 cites W2106857639 @default.
- W2914970060 cites W2117912414 @default.
- W2914970060 cites W2122070496 @default.
- W2914970060 cites W2130394726 @default.
- W2914970060 cites W2132793695 @default.
- W2914970060 cites W2141075182 @default.
- W2914970060 cites W2147433402 @default.
- W2914970060 cites W2148899088 @default.
- W2914970060 cites W2155612513 @default.
- W2914970060 cites W2171493278 @default.
- W2914970060 cites W2174603379 @default.
- W2914970060 cites W2387503045 @default.
- W2914970060 cites W2464884339 @default.
- W2914970060 cites W2507932427 @default.
- W2914970060 cites W2604662273 @default.
- W2914970060 cites W2751832049 @default.
- W2914970060 cites W2791849537 @default.
- W2914970060 cites W4245997933 @default.
- W2914970060 doi "https://doi.org/10.1007/s13205-019-1619-6" @default.
- W2914970060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6385074" @default.
- W2914970060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30800596" @default.
- W2914970060 hasPublicationYear "2019" @default.
- W2914970060 type Work @default.
- W2914970060 sameAs 2914970060 @default.
- W2914970060 citedByCount "16" @default.
- W2914970060 countsByYear W29149700602019 @default.
- W2914970060 countsByYear W29149700602021 @default.
- W2914970060 countsByYear W29149700602022 @default.
- W2914970060 countsByYear W29149700602023 @default.
- W2914970060 crossrefType "journal-article" @default.
- W2914970060 hasAuthorship W2914970060A5001649087 @default.
- W2914970060 hasAuthorship W2914970060A5025437312 @default.
- W2914970060 hasAuthorship W2914970060A5069771802 @default.
- W2914970060 hasAuthorship W2914970060A5075284628 @default.
- W2914970060 hasBestOaLocation W29149700601 @default.
- W2914970060 hasConcept C104317684 @default.
- W2914970060 hasConcept C150903083 @default.
- W2914970060 hasConcept C181199279 @default.
- W2914970060 hasConcept C185592680 @default.
- W2914970060 hasConcept C191908910 @default.
- W2914970060 hasConcept C2777431362 @default.
- W2914970060 hasConcept C2778278337 @default.
- W2914970060 hasConcept C31903555 @default.
- W2914970060 hasConcept C515207424 @default.
- W2914970060 hasConcept C547475151 @default.
- W2914970060 hasConcept C55493867 @default.
- W2914970060 hasConcept C6350086 @default.
- W2914970060 hasConcept C70721500 @default.
- W2914970060 hasConcept C86803240 @default.