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- W2914972051 abstract "Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. The mostly studied NT is brain-derived neurotrophic factor (BDNF). Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin–angiotensin system and endothelial nitric oxide synthase. BDNF was also found to be the predictor of CV outcome in different patient populations. Other types of human NT-s, such as nerve growth factor, neurotrophin 3 and neurotrophin 4 also seem to have both psychopathological and CV connections. Our aim was to overview the present knowledge in this area, demonstrating a new aspect of the associations between mood disorders and CV diseases through the mediation of NTs. These findings might enlighten new psychosomatic connections and suggest new therapeutic targets that are beneficial both in respect of mood disorders and CV pathology." @default.
- W2914972051 created "2019-02-21" @default.
- W2914972051 creator A5014999963 @default.
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- W2914972051 creator A5075939927 @default.
- W2914972051 creator A5076929032 @default.
- W2914972051 creator A5090975339 @default.
- W2914972051 date "2019-02-14" @default.
- W2914972051 modified "2023-10-15" @default.
- W2914972051 title "The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections" @default.
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