FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914978609> ?p ?o ?g. }

• W2914978609 endingPage "72" @default.
• W2914978609 startingPage "62" @default.
• W2914978609 abstract "BackgroundNonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment and a reversal of NASH progression and/or regression of the disease. Nitro-oleic acid (OA-NO2) has been proven effective in multiple experimental models of inflammation and fibrosis. Thus, the potential benefit of in vivo administration of OA-NO2 to treat advanced NAFLD was tested herein in a model of long-term NASH diet-induced liver damage.MethodsNon-invasive imaging (e.g. photoacustic-ultrasound (PA-US)) was pursued to establish advanced experimental model of NASH in mice in which both steatosis and fibrosis were diagnosed prior experimental therapy with OA-NO2. Experimental controls included equimolar amounts of the non-nitrated oleic acid (OA). CLAMS and NMR-based analysis was used for energy metabolism.FindingsCLAMS and NMR-based analysis demonstrates that OA-NO2 improves body composition and energy metabolism and inhibits hepatic triglyceride (TG) accumulation. Photoacoustic-ultrasound imaging revealed a robust inhibition of liver steatosis and fibrosis by OA-NO2. RNA-sequencing analysis uncovered inflammation and fibrosis as major pathways suppressed by OA-NO2 administration, as well as regulation of lipogenesis and lipolysis pathways, with a robust inhibition of SREBP1 proteolytic activation and subsequent lipogenesis gene expression by OA-NO2. These results were further supported by histological analysis and quantification of lipid accumulation, lobular inflammation (F4/80 staining) and fibrosis (collagen deposition, αSMA staining) as well as established parameters of liver damage (ALT). In vitro studies indicate that OA-NO2 inhibits TG biosynthesis and accumulation in hepatocytes and inhibits fibrogenesis in human stellate cells.InterpretationOA-NO2 improve steatohepatitis and fibrosis and may constitute an effective therapeutic approach against advanced NAFLD that warrants further clinical evaluation." @default.
• W2914978609 created "2019-02-21" @default.
• W2914978609 creator A5010283621 @default.
• W2914978609 creator A5013292090 @default.
• W2914978609 creator A5024844590 @default.
• W2914978609 creator A5030691366 @default.
• W2914978609 creator A5031129296 @default.
• W2914978609 creator A5038686753 @default.
• W2914978609 creator A5044540974 @default.
• W2914978609 creator A5048206421 @default.
• W2914978609 creator A5049130532 @default.
• W2914978609 creator A5052487247 @default.
• W2914978609 creator A5067616037 @default.
• W2914978609 creator A5071587889 @default.
• W2914978609 creator A5074847789 @default.
• W2914978609 creator A5082458281 @default.
• W2914978609 creator A5082637623 @default.
• W2914978609 creator A5087622795 @default.
• W2914978609 creator A5090615596 @default.
• W2914978609 date "2019-03-01" @default.
• W2914978609 modified "2023-10-14" @default.
• W2914978609 title "Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice" @default.
• W2914978609 cites W1882608036 @default.
• W2914978609 cites W2011184478 @default.
• W2914978609 cites W2028951926 @default.
• W2914978609 cites W2045130096 @default.
• W2914978609 cites W2049659786 @default.
• W2914978609 cites W2058502722 @default.
• W2914978609 cites W2060205727 @default.
• W2914978609 cites W2065612971 @default.
• W2914978609 cites W2075290880 @default.
• W2914978609 cites W2096947328 @default.
• W2914978609 cites W2097005377 @default.
• W2914978609 cites W2108913635 @default.
• W2914978609 cites W2113274715 @default.
• W2914978609 cites W2161481261 @default.
• W2914978609 cites W2164906049 @default.
• W2914978609 cites W2168398545 @default.
• W2914978609 cites W2174588307 @default.
• W2914978609 cites W2182296731 @default.
• W2914978609 cites W2204688218 @default.
• W2914978609 cites W2235204707 @default.
• W2914978609 cites W2294346279 @default.
• W2914978609 cites W2404306813 @default.
• W2914978609 cites W2415147586 @default.
• W2914978609 cites W2557798862 @default.
• W2914978609 cites W2759997926 @default.
• W2914978609 cites W2760098333 @default.
• W2914978609 cites W2767673297 @default.
• W2914978609 cites W2770634512 @default.
• W2914978609 cites W2774672890 @default.
• W2914978609 cites W2778677617 @default.
• W2914978609 cites W2782417153 @default.
• W2914978609 cites W2783369484 @default.
• W2914978609 cites W2794075623 @default.
• W2914978609 cites W2794379113 @default.
• W2914978609 cites W2802631032 @default.
• W2914978609 cites W2808659055 @default.
• W2914978609 cites W2808672726 @default.
• W2914978609 cites W2810423511 @default.
• W2914978609 cites W2811163292 @default.
• W2914978609 cites W2885309985 @default.
• W2914978609 cites W2902538813 @default.
• W2914978609 cites W2909812323 @default.
• W2914978609 doi "https://doi.org/10.1016/j.ebiom.2019.02.019" @default.
• W2914978609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6444056" @default.
• W2914978609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30772307" @default.
• W2914978609 hasPublicationYear "2019" @default.
• W2914978609 type Work @default.
• W2914978609 sameAs 2914978609 @default.
• W2914978609 citedByCount "42" @default.
• W2914978609 countsByYear W29149786092019 @default.
• W2914978609 countsByYear W29149786092020 @default.
• W2914978609 countsByYear W29149786092021 @default.
• W2914978609 countsByYear W29149786092022 @default.
• W2914978609 countsByYear W29149786092023 @default.
• W2914978609 crossrefType "journal-article" @default.
• W2914978609 hasAuthorship W2914978609A5010283621 @default.
• W2914978609 hasAuthorship W2914978609A5013292090 @default.
• W2914978609 hasAuthorship W2914978609A5024844590 @default.
• W2914978609 hasAuthorship W2914978609A5030691366 @default.
• W2914978609 hasAuthorship W2914978609A5031129296 @default.
• W2914978609 hasAuthorship W2914978609A5038686753 @default.
• W2914978609 hasAuthorship W2914978609A5044540974 @default.
• W2914978609 hasAuthorship W2914978609A5048206421 @default.
• W2914978609 hasAuthorship W2914978609A5049130532 @default.
• W2914978609 hasAuthorship W2914978609A5052487247 @default.
• W2914978609 hasAuthorship W2914978609A5067616037 @default.
• W2914978609 hasAuthorship W2914978609A5071587889 @default.
• W2914978609 hasAuthorship W2914978609A5074847789 @default.
• W2914978609 hasAuthorship W2914978609A5082458281 @default.
• W2914978609 hasAuthorship W2914978609A5082637623 @default.
• W2914978609 hasAuthorship W2914978609A5087622795 @default.
• W2914978609 hasAuthorship W2914978609A5090615596 @default.
• W2914978609 hasBestOaLocation W29149786091 @default.
• W2914978609 hasConcept C126322002 @default.
• W2914978609 hasConcept C134018914 @default.
• W2914978609 hasConcept C141359234 @default.

• next