FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914989841> ?p ?o ?g. }

• W2914989841 endingPage "339" @default.
• W2914989841 startingPage "331" @default.
• W2914989841 abstract "Background: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is commonly performed on plasma or serum. The use of dried plasma spots (DPSs) could represent a useful tool to facilitate sample shipment to reference laboratories. In this article, the authors describe the application of a commercially available UHPLC-MS/MS method for the determination of 9 commonly prescribed AEDs (levetiracetam, lacosamide, topiramate, ethosuximide, lamotrigine, rufinamide, zonisamide, primidone, and oxcarbazepine and its active metabolite 10-OH-monohydroxycarbazepine) to DPS collected on dried sample spot devices (DSSDs). Method: Fifty microliters of plasma were spotted on DSSD. After being air-dried at room temperature, they were extracted using an organic extraction solution containing the appropriate deuterated internal standards. The chromatographic separation was performed on a UHPLC reversed-phase C-18 column, and the analytes were quantified using a triple quadrupole mass spectrometer (LC-MS/MS). Results: The assay was linear over the concentration ranges tested with a total runtime of 10.3 minutes. Recovery ranged from 93.7% to 106.8%. Intraday and interday precision for all quality control levels, including lower limit of quantification, ranged from 2.1% to 18.4% and 2.1% to 13.2%. Intraday and interday accuracy biases ranged from −11.7% to 14.3% and −9.2% to 8.0%. The absence of matrix effects was also tested and confirmed. Real samples derived from patients under therapy were also analyzed, and the comparison of results obtained from DSSD with those obtained from plasma showed that the 2 matrices were interchangeable. Stability tests performed on both quality controls, and real samples demonstrated that DSSDs can be easily stored and shipped at room temperature for 15 days. Conclusions: The application of the LC-MS/MS method allowed the authors to obtain a very specific, sensitive, and rapid (total runtime = 10.3 minutes) quantification of 9 AEDs starting from very low volumes of plasma samples. The main advantage of DPS over wet samples is room temperature storage and shipment, which lowers shipment costs and makes it suitable for routine TDM. Moreover, in comparison with other alternative matrices, DPS allows for the use of the same therapeutic ranges on which routine TDM is based. DPS on DSSD can thus be considered as a useful and cheap tool for the broader application of TDM." @default.
• W2914989841 created "2019-02-21" @default.
• W2914989841 creator A5028645808 @default.
• W2914989841 creator A5033455991 @default.
• W2914989841 creator A5060407769 @default.
• W2914989841 creator A5074440176 @default.
• W2914989841 creator A5076836884 @default.
• W2914989841 creator A5088309302 @default.
• W2914989841 date "2019-06-01" @default.
• W2914989841 modified "2023-10-17" @default.
• W2914989841 title "LC-MS/MS-Based Quantification of 9 Antiepileptic Drugs From a Dried Sample Spot Device" @default.
• W2914989841 cites W1920696238 @default.
• W2914989841 cites W1978551870 @default.
• W2914989841 cites W1978789398 @default.
• W2914989841 cites W2002426184 @default.
• W2914989841 cites W2010680811 @default.
• W2914989841 cites W2032655978 @default.
• W2914989841 cites W2040995547 @default.
• W2914989841 cites W2042516926 @default.
• W2914989841 cites W2043216606 @default.
• W2914989841 cites W2046528107 @default.
• W2914989841 cites W2050226999 @default.
• W2914989841 cites W2050831388 @default.
• W2914989841 cites W2059549542 @default.
• W2914989841 cites W2060587811 @default.
• W2914989841 cites W2077008944 @default.
• W2914989841 cites W2081017554 @default.
• W2914989841 cites W2085806712 @default.
• W2914989841 cites W2116461094 @default.
• W2914989841 cites W2148904065 @default.
• W2914989841 cites W2320685137 @default.
• W2914989841 cites W2347047707 @default.
• W2914989841 cites W2483242681 @default.
• W2914989841 cites W2490909274 @default.
• W2914989841 cites W2536269490 @default.
• W2914989841 cites W2564094638 @default.
• W2914989841 cites W2592509339 @default.
• W2914989841 cites W2738767870 @default.
• W2914989841 cites W2753966476 @default.
• W2914989841 cites W2791002457 @default.
• W2914989841 cites W4232908185 @default.
• W2914989841 doi "https://doi.org/10.1097/ftd.0000000000000600" @default.
• W2914989841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30688867" @default.
• W2914989841 hasPublicationYear "2019" @default.
• W2914989841 type Work @default.
• W2914989841 sameAs 2914989841 @default.
• W2914989841 citedByCount "21" @default.
• W2914989841 countsByYear W29149898412020 @default.
• W2914989841 countsByYear W29149898412021 @default.
• W2914989841 countsByYear W29149898412022 @default.
• W2914989841 countsByYear W29149898412023 @default.
• W2914989841 crossrefType "journal-article" @default.
• W2914989841 hasAuthorship W2914989841A5028645808 @default.
• W2914989841 hasAuthorship W2914989841A5033455991 @default.
• W2914989841 hasAuthorship W2914989841A5060407769 @default.
• W2914989841 hasAuthorship W2914989841A5074440176 @default.
• W2914989841 hasAuthorship W2914989841A5076836884 @default.
• W2914989841 hasAuthorship W2914989841A5088309302 @default.
• W2914989841 hasConcept C10390740 @default.
• W2914989841 hasConcept C112705442 @default.
• W2914989841 hasConcept C118552586 @default.
• W2914989841 hasConcept C162356407 @default.
• W2914989841 hasConcept C172493649 @default.
• W2914989841 hasConcept C185592680 @default.
• W2914989841 hasConcept C2776597655 @default.
• W2914989841 hasConcept C2777138316 @default.
• W2914989841 hasConcept C2777332695 @default.
• W2914989841 hasConcept C2777683783 @default.
• W2914989841 hasConcept C2777992146 @default.
• W2914989841 hasConcept C2778139780 @default.
• W2914989841 hasConcept C2778186239 @default.
• W2914989841 hasConcept C2778337148 @default.
• W2914989841 hasConcept C2778576202 @default.
• W2914989841 hasConcept C2778802184 @default.
• W2914989841 hasConcept C2779253243 @default.
• W2914989841 hasConcept C2780272996 @default.
• W2914989841 hasConcept C2781176495 @default.
• W2914989841 hasConcept C31827203 @default.
• W2914989841 hasConcept C43617362 @default.
• W2914989841 hasConcept C71043704 @default.
• W2914989841 hasConcept C71924100 @default.
• W2914989841 hasConcept C98274493 @default.
• W2914989841 hasConceptScore W2914989841C10390740 @default.
• W2914989841 hasConceptScore W2914989841C112705442 @default.
• W2914989841 hasConceptScore W2914989841C118552586 @default.
• W2914989841 hasConceptScore W2914989841C162356407 @default.
• W2914989841 hasConceptScore W2914989841C172493649 @default.
• W2914989841 hasConceptScore W2914989841C185592680 @default.
• W2914989841 hasConceptScore W2914989841C2776597655 @default.
• W2914989841 hasConceptScore W2914989841C2777138316 @default.
• W2914989841 hasConceptScore W2914989841C2777332695 @default.
• W2914989841 hasConceptScore W2914989841C2777683783 @default.
• W2914989841 hasConceptScore W2914989841C2777992146 @default.
• W2914989841 hasConceptScore W2914989841C2778139780 @default.
• W2914989841 hasConceptScore W2914989841C2778186239 @default.
• W2914989841 hasConceptScore W2914989841C2778337148 @default.
• W2914989841 hasConceptScore W2914989841C2778576202 @default.
• W2914989841 hasConceptScore W2914989841C2778802184 @default.

• next