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- W2914998730 abstract "Introduction: The Tranexamic acid for IntraCerebral Haemorrhage-2 (TICH-2) trial reported no significant improvement in death and dependency at day 90 despite reduction in haematoma expansion and early neurological deterioration. However, significant recovery after stroke, particularly intracerebral haemorrhage may take more than 3 months. Here we will report the participant outcomes one year after stroke. Methods: TICH-2 was a prospective randomised controlled trial that tested the efficacy and safety of tranexamic acid in spontaneous intracerebral haemorrhage when given within 8 hours of onset. Centralised blinded telephone follow up was performed for patients from the United Kingdom at Day 365. Outcome assessments included modified Rankin Scale, Barthel index, Telephone Interview Cognitive Status-modified, EuroQoL-5D and Zung Depression Scale. Results: 2325 patients were recruited into the trial (age 68.9 ±13.8 years; 1301 male, 56%). 1161 participants were assigned to tranexamic acid and 1164 participants to placebo. 1909 participants (82.1%) were recruited from the United Kingdom and eligible for day 365 follow up. 81 patients (4.2%) were lost to follow up. Of the 1800 patients with available outcome to date, 609 (33.8%) died while 1003 (55.6%) had poor functional outcome (modified Rankin Scale 4 to 6). Conclusion: This is a place-holding abstract for the results of the ongoing day 365 follow-up of TICH-2. To our knowledge this will be the largest long term follow-up of patients with intracerebral haemorrhage." @default.
- W2914998730 created "2019-02-21" @default.
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- W2914998730 date "2019-02-01" @default.
- W2914998730 modified "2023-09-26" @default.
- W2914998730 title "Abstract 16: The Tranexamic Acid for Intracerebral Haemorrhage-2 (TICH-2) Trial: Results of One Year Follow Up Data" @default.
- W2914998730 doi "https://doi.org/10.1161/str.50.suppl_1.16" @default.
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