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• W2915012609 abstract "To better understand the toxicological activities of perfluorooctanoic acid (PFOA), we examined the effects of PFOA on apoptosis and its molecular mechanism in SMMC-7721 hepatoma cells. Cell viability was evaluated by MTT assay and apoptosis was determined by flow cytometry. Western blot and quantitative real-time PCR were used to examine the protein and gene expressions of Bax and Bcl-2. Our results showed that PFOA inhibited SMMC-7721 cell growth and induced apoptosis. PFOA treatment increased Bax expression and increased Bcl-2 expression at both gene and protein levels. Our study demonstrated that PFOA had toxic effects on SMMC-7721 cells, such as inhibiting cell proliferation and inducing apoptosis. Furthermore, we showed that PFOA-mediated induction of apoptosis involved inducing Bax and decreasing Bcl-2 expression as a molecular mechanism of its toxicological effects." @default.
• W2915012609 created "2019-02-21" @default.
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• W2915012609 date "2019-04-01" @default.
• W2915012609 modified "2023-10-17" @default.
• W2915012609 title "Perfluorooctanoic acid exposure induces apoptosis in SMMC-7721 hepatocellular cancer cells" @default.
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• W2915012609 doi "https://doi.org/10.1016/j.envpol.2019.01.035" @default.
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