FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915073513> ?p ?o ?g. }

• W2915073513 endingPage "639" @default.
• W2915073513 startingPage "631" @default.
• W2915073513 abstract "Abstract Induced pluripotent stem cells (iPSCs) can attenuate the pathological severity and neutrophil migration of lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, interactions that may occur between iPSCs and the triggering receptor expressed on myeloid cells (TREM) family of proteins remain unclear. In this study, murine iPSCs (miPSCs) were delivered via tail vein injection to wild type, TREM-1 knockout (KO), and TREM-2 KO C57BL/6 mice 4 hours after an intratracheal delivery of LPS. Twenty-four hours later, the bronchoalveolar lavage fluid and lung tissue were collected to perform histology, immunohistochemistry, neutrophil counts, Western blot assays, and enzyme-linked immunosorbent assays. Neutrophils were also isolated from the bone marrow to perform in vitro migration assays. In the lung tissues collected, LPS increased the expression of TREM-1 and TREM-2, with the TREM-2 KO mice expressing more TREM-1 than the wild-type mice. The TREM-2 KO mice also exhibited greater severity of LPS-induced ALI, enhanced neutrophil infiltration in the lung tissues, and a higher ratio of phosphorylated p38 to total p38 (p-p38/p38) in neutrophils. The p-p38/p38 ratio and the expression of vascular cell adhesion molecule-1 and certain proinflammatory cytokines (macrophage inflammatory protein-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β) were increased in whole lung extracts following LPS-induced ALI, and these levels were even more in LPS-treated TREM-2 KO mice. These effects were reduced when miPSCs were administered. Thus, the results of this study suggest that miPSCs attenuate the role of neutrophils in lung inflammation and injury induced by LPS by reducing their expression of TREM-1 and p38 mitogen-activated protein kinase signaling. Stem Cells 2019;37:631–639" @default.
• W2915073513 created "2019-03-02" @default.
• W2915073513 creator A5015081928 @default.
• W2915073513 creator A5023233909 @default.
• W2915073513 creator A5053348907 @default.
• W2915073513 creator A5056827907 @default.
• W2915073513 creator A5074418474 @default.
• W2915073513 creator A5081000027 @default.
• W2915073513 creator A5082647777 @default.
• W2915073513 date "2019-02-16" @default.
• W2915073513 modified "2023-10-15" @default.
• W2915073513 title "Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury" @default.
• W2915073513 cites W1643888758 @default.
• W2915073513 cites W1926302666 @default.
• W2915073513 cites W1975974673 @default.
• W2915073513 cites W1977707794 @default.
• W2915073513 cites W2002666280 @default.
• W2915073513 cites W2008338946 @default.
• W2915073513 cites W2032731042 @default.
• W2915073513 cites W2053911973 @default.
• W2915073513 cites W2058490849 @default.
• W2915073513 cites W2092035190 @default.
• W2915073513 cites W2102424826 @default.
• W2915073513 cites W2112373432 @default.
• W2915073513 cites W2113064104 @default.
• W2915073513 cites W2115341926 @default.
• W2915073513 cites W2118751252 @default.
• W2915073513 cites W2125987139 @default.
• W2915073513 cites W2133084626 @default.
• W2915073513 cites W2143158290 @default.
• W2915073513 cites W2149698238 @default.
• W2915073513 cites W2156153766 @default.
• W2915073513 cites W2158534694 @default.
• W2915073513 cites W2162885959 @default.
• W2915073513 cites W2182355171 @default.
• W2915073513 cites W2220734173 @default.
• W2915073513 cites W2375772230 @default.
• W2915073513 cites W2510385322 @default.
• W2915073513 cites W2606626763 @default.
• W2915073513 cites W4313308248 @default.
• W2915073513 doi "https://doi.org/10.1002/stem.2980" @default.
• W2915073513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30681755" @default.
• W2915073513 hasPublicationYear "2019" @default.
• W2915073513 type Work @default.
• W2915073513 sameAs 2915073513 @default.
• W2915073513 citedByCount "15" @default.
• W2915073513 countsByYear W29150735132019 @default.
• W2915073513 countsByYear W29150735132020 @default.
• W2915073513 countsByYear W29150735132021 @default.
• W2915073513 countsByYear W29150735132022 @default.
• W2915073513 countsByYear W29150735132023 @default.
• W2915073513 crossrefType "journal-article" @default.
• W2915073513 hasAuthorship W2915073513A5015081928 @default.
• W2915073513 hasAuthorship W2915073513A5023233909 @default.
• W2915073513 hasAuthorship W2915073513A5053348907 @default.
• W2915073513 hasAuthorship W2915073513A5056827907 @default.
• W2915073513 hasAuthorship W2915073513A5074418474 @default.
• W2915073513 hasAuthorship W2915073513A5081000027 @default.
• W2915073513 hasAuthorship W2915073513A5082647777 @default.
• W2915073513 hasBestOaLocation W29150735131 @default.
• W2915073513 hasConcept C104317684 @default.
• W2915073513 hasConcept C126322002 @default.
• W2915073513 hasConcept C164027704 @default.
• W2915073513 hasConcept C170493617 @default.
• W2915073513 hasConcept C17991360 @default.
• W2915073513 hasConcept C184235292 @default.
• W2915073513 hasConcept C203014093 @default.
• W2915073513 hasConcept C2776415932 @default.
• W2915073513 hasConcept C2776914184 @default.
• W2915073513 hasConcept C2777714996 @default.
• W2915073513 hasConcept C2777961210 @default.
• W2915073513 hasConcept C2778754761 @default.
• W2915073513 hasConcept C51551487 @default.
• W2915073513 hasConcept C55493867 @default.
• W2915073513 hasConcept C71924100 @default.
• W2915073513 hasConcept C86803240 @default.
• W2915073513 hasConcept C95444343 @default.
• W2915073513 hasConcept C97029542 @default.
• W2915073513 hasConceptScore W2915073513C104317684 @default.
• W2915073513 hasConceptScore W2915073513C126322002 @default.
• W2915073513 hasConceptScore W2915073513C164027704 @default.
• W2915073513 hasConceptScore W2915073513C170493617 @default.
• W2915073513 hasConceptScore W2915073513C17991360 @default.
• W2915073513 hasConceptScore W2915073513C184235292 @default.
• W2915073513 hasConceptScore W2915073513C203014093 @default.
• W2915073513 hasConceptScore W2915073513C2776415932 @default.
• W2915073513 hasConceptScore W2915073513C2776914184 @default.
• W2915073513 hasConceptScore W2915073513C2777714996 @default.
• W2915073513 hasConceptScore W2915073513C2777961210 @default.
• W2915073513 hasConceptScore W2915073513C2778754761 @default.
• W2915073513 hasConceptScore W2915073513C51551487 @default.
• W2915073513 hasConceptScore W2915073513C55493867 @default.
• W2915073513 hasConceptScore W2915073513C71924100 @default.
• W2915073513 hasConceptScore W2915073513C86803240 @default.
• W2915073513 hasConceptScore W2915073513C95444343 @default.
• W2915073513 hasConceptScore W2915073513C97029542 @default.
• W2915073513 hasFunder F4320327358 @default.
• W2915073513 hasIssue "5" @default.

• next