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• W2915129194 abstract "The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells. Tumor associated macrophages (TAMs) showing functional plasticity contribute to this process as so called M2-like macrophages can suppress the function of effector T cells and promote their differentiation into regulatory T cells (Tregs). Furthermore, tumor antigen specific CD4+ T effector cells can essentially sustain anti-tumoral immune responses as shown for various tumor entities, thus suggesting that cognate interaction between tumor antigen-specific CD4+ T cells and TAMs might shift the intra-tumoral M1/M2 ratio towards M1. This study demonstrates repolarization of M2 like PECs upon MHC II-restricted interaction with tumor specific CD4+ T cells in vitro as shown by extensive gene and protein expression analyses. Moreover, adoptive transfer of OVA-specific OT-II cells into C57BL/6 mice bearing OVA expressing IAb-/- tumors resulted in increased accumulation of M1-like TAMs with enhanced M1 associated gene and protein expression profiles. Thus, this paper highlights a so far underestimated function of the CD4+ T cell / TAM axis in re-conditioning the immunosuppressive tumor microenvironment." @default.
• W2915129194 created "2019-03-02" @default.
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• W2915129194 date "2019-02-22" @default.
• W2915129194 modified "2023-10-17" @default.
• W2915129194 title "Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype" @default.
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• W2915129194 doi "https://doi.org/10.3389/fimmu.2019.00219" @default.
• W2915129194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6395406" @default.
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• W2915129194 hasPublicationYear "2019" @default.
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