Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915202693> ?p ?o ?g. }
- W2915202693 endingPage "470.e9" @default.
- W2915202693 startingPage "463" @default.
- W2915202693 abstract "The pathogenesis of Staphylococcus aureus is thought to depend on the production of pore-forming leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin ED (LukED) and γ-Hemolysin AB (HlgAB), are necessary and sufficient to kill mice upon infection and toxin challenge. We demonstrate that LukED and HlgAB cause vascular congestion and derangements in vascular fluid distribution that rapidly cause death in mice. The Duffy antigen receptor for chemokines (DARC) on endothelial cells, rather than leukocytes or erythrocytes, is the critical target for lethality. Consistent with this, LukED and HlgAB injure primary human endothelial cells in a DARC-dependent manner, and mice with DARC-deficient endothelial cells are resistant to toxin-mediated lethality. During bloodstream infection in mice, DARC targeting by S. aureus causes increased tissue damage, organ dysfunction, and host death. The potential for S. aureus leukocidins to manipulate vascular integrity highlights the importance of these virulence factors." @default.
- W2915202693 created "2019-03-02" @default.
- W2915202693 creator A5003567187 @default.
- W2915202693 creator A5009231300 @default.
- W2915202693 creator A5014150213 @default.
- W2915202693 creator A5014312576 @default.
- W2915202693 creator A5017737894 @default.
- W2915202693 creator A5022156816 @default.
- W2915202693 creator A5023645521 @default.
- W2915202693 creator A5023907407 @default.
- W2915202693 creator A5024757326 @default.
- W2915202693 creator A5029344452 @default.
- W2915202693 creator A5032992726 @default.
- W2915202693 creator A5040175618 @default.
- W2915202693 creator A5040190745 @default.
- W2915202693 creator A5043455810 @default.
- W2915202693 creator A5044799381 @default.
- W2915202693 creator A5049148882 @default.
- W2915202693 creator A5051423416 @default.
- W2915202693 creator A5052332035 @default.
- W2915202693 creator A5058791363 @default.
- W2915202693 creator A5063528974 @default.
- W2915202693 creator A5064082463 @default.
- W2915202693 creator A5064520181 @default.
- W2915202693 creator A5065360311 @default.
- W2915202693 creator A5067756034 @default.
- W2915202693 creator A5068948660 @default.
- W2915202693 creator A5072321111 @default.
- W2915202693 creator A5076576391 @default.
- W2915202693 creator A5077683458 @default.
- W2915202693 creator A5083419483 @default.
- W2915202693 creator A5090468389 @default.
- W2915202693 creator A5090493321 @default.
- W2915202693 date "2019-03-01" @default.
- W2915202693 modified "2023-10-16" @default.
- W2915202693 title "Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice" @default.
- W2915202693 cites W1540141473 @default.
- W2915202693 cites W178070940 @default.
- W2915202693 cites W1941322164 @default.
- W2915202693 cites W1965117293 @default.
- W2915202693 cites W1971677443 @default.
- W2915202693 cites W1979135961 @default.
- W2915202693 cites W1993578627 @default.
- W2915202693 cites W1996453015 @default.
- W2915202693 cites W2020760594 @default.
- W2915202693 cites W2034550137 @default.
- W2915202693 cites W2036177806 @default.
- W2915202693 cites W2037679972 @default.
- W2915202693 cites W2040559263 @default.
- W2915202693 cites W2041628594 @default.
- W2915202693 cites W2043803772 @default.
- W2915202693 cites W2052831663 @default.
- W2915202693 cites W2055992413 @default.
- W2915202693 cites W2067215762 @default.
- W2915202693 cites W2070763664 @default.
- W2915202693 cites W2071022240 @default.
- W2915202693 cites W2083169658 @default.
- W2915202693 cites W2084502463 @default.
- W2915202693 cites W2090859543 @default.
- W2915202693 cites W2103459076 @default.
- W2915202693 cites W2112087685 @default.
- W2915202693 cites W2119750924 @default.
- W2915202693 cites W2121452572 @default.
- W2915202693 cites W2124904530 @default.
- W2915202693 cites W2125066910 @default.
- W2915202693 cites W2132930906 @default.
- W2915202693 cites W2138638997 @default.
- W2915202693 cites W2152783224 @default.
- W2915202693 cites W2154734807 @default.
- W2915202693 cites W2157288494 @default.
- W2915202693 cites W2157376532 @default.
- W2915202693 cites W2262415294 @default.
- W2915202693 cites W2263759014 @default.
- W2915202693 cites W2564806342 @default.
- W2915202693 cites W2607187374 @default.
- W2915202693 cites W2614625323 @default.
- W2915202693 cites W2781767175 @default.
- W2915202693 cites W4230311653 @default.
- W2915202693 cites W569256461 @default.
- W2915202693 cites W596660519 @default.
- W2915202693 doi "https://doi.org/10.1016/j.chom.2019.01.015" @default.
- W2915202693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6468323" @default.
- W2915202693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30799265" @default.
- W2915202693 hasPublicationYear "2019" @default.
- W2915202693 type Work @default.
- W2915202693 sameAs 2915202693 @default.
- W2915202693 citedByCount "25" @default.
- W2915202693 countsByYear W29152026932019 @default.
- W2915202693 countsByYear W29152026932020 @default.
- W2915202693 countsByYear W29152026932021 @default.
- W2915202693 countsByYear W29152026932022 @default.
- W2915202693 countsByYear W29152026932023 @default.
- W2915202693 crossrefType "journal-article" @default.
- W2915202693 hasAuthorship W2915202693A5003567187 @default.
- W2915202693 hasAuthorship W2915202693A5009231300 @default.
- W2915202693 hasAuthorship W2915202693A5014150213 @default.
- W2915202693 hasAuthorship W2915202693A5014312576 @default.
- W2915202693 hasAuthorship W2915202693A5017737894 @default.