Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915206100> ?p ?o ?g. }
- W2915206100 abstract "Outer hair cells (OHCs) are highly specialized sensory cells conferring the fine-tuning and high sensitivity of the mammalian cochlea to acoustic stimuli. Here, by genetically manipulating spontaneous Ca2+ signalling in mice in vivo, through a period of early postnatal development, we find that the refinement of OHC afferent innervation is regulated by complementary spontaneous Ca2+ signals originating in OHCs and non-sensory cells. OHCs fire spontaneous Ca2+ action potentials during a narrow period of neonatal development. Simultaneously, waves of Ca2+ activity in the non-sensory cells of the greater epithelial ridge cause, via ATP-induced activation of P2X3 receptors, the increase and synchronization of the Ca2+ activity in nearby OHCs. This synchronization is required for the refinement of their immature afferent innervation. In the absence of connexin channels, Ca2+ waves are impaired, leading to a reduction in the number of ribbon synapses and afferent fibres on OHCs. We propose that the correct maturation of the afferent connectivity of OHCs requires experience-independent Ca2+ signals from sensory and non-sensory cells." @default.
- W2915206100 created "2019-03-02" @default.
- W2915206100 creator A5009013340 @default.
- W2915206100 creator A5009920069 @default.
- W2915206100 creator A5011563842 @default.
- W2915206100 creator A5013013006 @default.
- W2915206100 creator A5019241764 @default.
- W2915206100 creator A5021122518 @default.
- W2915206100 creator A5029526235 @default.
- W2915206100 creator A5048337066 @default.
- W2915206100 creator A5049410040 @default.
- W2915206100 creator A5050316905 @default.
- W2915206100 creator A5068080149 @default.
- W2915206100 creator A5083691330 @default.
- W2915206100 date "2019-02-25" @default.
- W2915206100 modified "2023-10-16" @default.
- W2915206100 title "Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells" @default.
- W2915206100 cites W146901554 @default.
- W2915206100 cites W1535462101 @default.
- W2915206100 cites W1765574357 @default.
- W2915206100 cites W1880474603 @default.
- W2915206100 cites W1963806203 @default.
- W2915206100 cites W1966389722 @default.
- W2915206100 cites W1974813892 @default.
- W2915206100 cites W1985004569 @default.
- W2915206100 cites W1985132883 @default.
- W2915206100 cites W1986408320 @default.
- W2915206100 cites W1986733224 @default.
- W2915206100 cites W1987343613 @default.
- W2915206100 cites W1987523411 @default.
- W2915206100 cites W1992961518 @default.
- W2915206100 cites W1993355218 @default.
- W2915206100 cites W1997948934 @default.
- W2915206100 cites W1999914498 @default.
- W2915206100 cites W2004852021 @default.
- W2915206100 cites W2005190025 @default.
- W2915206100 cites W2006623752 @default.
- W2915206100 cites W2007417371 @default.
- W2915206100 cites W2012699482 @default.
- W2915206100 cites W2013496968 @default.
- W2915206100 cites W2017022046 @default.
- W2915206100 cites W2018868878 @default.
- W2915206100 cites W2022743067 @default.
- W2915206100 cites W2024476380 @default.
- W2915206100 cites W2025150024 @default.
- W2915206100 cites W2030167054 @default.
- W2915206100 cites W2033046255 @default.
- W2915206100 cites W2035657815 @default.
- W2915206100 cites W2036698172 @default.
- W2915206100 cites W2038717281 @default.
- W2915206100 cites W2042768034 @default.
- W2915206100 cites W2044500873 @default.
- W2915206100 cites W2052424440 @default.
- W2915206100 cites W2056307676 @default.
- W2915206100 cites W2056499295 @default.
- W2915206100 cites W2059743066 @default.
- W2915206100 cites W2069921694 @default.
- W2915206100 cites W2069993902 @default.
- W2915206100 cites W2072710884 @default.
- W2915206100 cites W2078082243 @default.
- W2915206100 cites W2082562281 @default.
- W2915206100 cites W2084005326 @default.
- W2915206100 cites W2084590508 @default.
- W2915206100 cites W2087539633 @default.
- W2915206100 cites W2088703515 @default.
- W2915206100 cites W2091804082 @default.
- W2915206100 cites W2092235580 @default.
- W2915206100 cites W2095198088 @default.
- W2915206100 cites W2102941077 @default.
- W2915206100 cites W2104988801 @default.
- W2915206100 cites W2112673780 @default.
- W2915206100 cites W2114237429 @default.
- W2915206100 cites W2117727547 @default.
- W2915206100 cites W2125211821 @default.
- W2915206100 cites W2127242552 @default.
- W2915206100 cites W2144088780 @default.
- W2915206100 cites W2147326824 @default.
- W2915206100 cites W2167279371 @default.
- W2915206100 cites W2169040201 @default.
- W2915206100 cites W2170730572 @default.
- W2915206100 cites W2175581229 @default.
- W2915206100 cites W2229355517 @default.
- W2915206100 cites W2231009150 @default.
- W2915206100 cites W2346281242 @default.
- W2915206100 cites W2417679830 @default.
- W2915206100 cites W2494656067 @default.
- W2915206100 cites W2555982009 @default.
- W2915206100 cites W2886288118 @default.
- W2915206100 cites W2886947645 @default.
- W2915206100 cites W2887693294 @default.
- W2915206100 cites W2891127204 @default.
- W2915206100 cites W2892586228 @default.
- W2915206100 cites W4243157173 @default.
- W2915206100 cites W974144396 @default.
- W2915206100 doi "https://doi.org/10.15252/embj.201899839" @default.
- W2915206100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6484507" @default.
- W2915206100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30804003" @default.
- W2915206100 hasPublicationYear "2019" @default.
- W2915206100 type Work @default.
- W2915206100 sameAs 2915206100 @default.