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• W2915206617 abstract "Multicellular organisms can be regarded as metaorganisms, comprising of a macroscopic host interacting with associated microorganisms. Within this alliance, the host has to ensure attracting beneficial bacteria and defending against pathogens to establish and maintain a healthy homeostasis. Here, we obtained several lines of evidence arguing that Aurelia aurita uses interference with bacterial quorum sensing (QS) - quorum quenching (QQ) - as one host defense mechanism. Three A. aurita-derived proteins interfering with bacterial QS were identified by functionally screening a metagenomic library constructed from medusa-derived mucus. Native expression patterns of these host open reading frames (ORFs) differed in the diverse life stages (associated with different microbiota) pointing to a specific role in establishing the developmental stage-specific microbiota. Highly increased expression of all QQ-ORFs in germ-free animals further indicates their impact on the microbiota. Moreover, incubation of native animals with pathogenic bacteria induced expression of the identified QQ-ORFs arguing for a host defense strategy against confronting bacteria by interference with bacterial QS. In agreement, immobilized recombinant QQ proteins induced restructuring of polyp-associated microbiota through changing abundance and operational taxonomic unit composition. Thus, we hypothesize that additional to the immune system host-derived QQ-activities potentially control bacterial colonization." @default.
• W2915206617 created "2019-03-02" @default.
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• W2915206617 date "2019-01-10" @default.
• W2915206617 modified "2023-10-17" @default.
• W2915206617 title "Potential role of host-derived quorum quenching in modulating bacterial colonization in the moon jellyfish Aurelia aurita" @default.
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• W2915206617 doi "https://doi.org/10.1038/s41598-018-37321-z" @default.
• W2915206617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6328592" @default.
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