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- W2915228852 abstract "Abstract Significantly increased production of biobased polymers is a prerequisite to replace petroleum‐based materials towards reaching a circular bioeconomy. However, many renewable building blocks from wood and other plant material are not directly amenable for polymerization, due to their inert backbones and/or lack of functional group compatibility with the desired polymerization type. Based on a retro‐biosynthetic analysis of polyesters, a chemoenzymatic route from (−)‐α‐pinene towards a verbanone‐based lactone, which is further used in ring‐opening polymerization, is presented. Generated pinene‐derived polyesters showed elevated degradation and glass transition temperatures, compared with poly(ϵ‐decalactone), which lacks a ring structure in its backbone. Semirational enzyme engineering of the cyclohexanone monooxygenase from Acinetobacter calcoaceticus enabled the biosynthesis of the key lactone intermediate for the targeted polyester. As a proof of principle, one enzyme variant identified from screening in a microtiter plate was used in biocatalytic upscaling, which afforded the bicyclic lactone in 39 % conversion in shake flask scale reactions." @default.
- W2915228852 created "2019-03-02" @default.
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- W2915228852 date "2019-05-21" @default.
- W2915228852 modified "2023-10-16" @default.
- W2915228852 title "A Retro‐biosynthesis‐Based Route to Generate Pinene‐Derived Polyesters" @default.
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- W2915228852 doi "https://doi.org/10.1002/cbic.201900046" @default.
- W2915228852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618282" @default.
- W2915228852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30793830" @default.