FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915393311> ?p ?o ?g. }

• W2915393311 endingPage "324" @default.
• W2915393311 startingPage "314" @default.
• W2915393311 abstract "Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors such as dimethyloxalylglycine (DMOG). By releasing DMOG from mesenchymal stem cell (MSC) laden alginate hydrogels, it is possible to stabilize HIF-1α and enhance its nuclear localization. This correlated with enhanced chondrogenesis and a reduction in the expression of markers associated with chondrocyte hypertrophy, as well as increased SMAD 2/3 nuclear localization in the encapsulated MSCs. In vivo, DMOG delivery significantly reduced mineralisation of the proteoglycan-rich cartilaginous tissue generated by MSCs within alginate hydrogels loaded with TGF-β3 and BMP-2. Together these findings point to the potential of hypoxia mimicking hydrogels to control the fate of stem cells following their implantation into the body. STATEMENT OF SIGNIFICANCE: There are relatively few examples where in vivo delivery of adult stem cells has demonstrated a true therapeutic benefit. This may be attributed, at least in part, to a failure to control the fate of transplanted stem cells in vivo. In this paper we describe the development of hydrogels that mimic the effects of hypoxia on encapsulated stem cells. In vitro, these hydrogels enhance chondrogenesis of MSCs and suppress markers associated with chondrocyte hypertrophy. In an in vivo environment that otherwise supports progression along an endochondral pathway, we show that these hydrogels will instead direct mesenchymal stem cells (MSCs) to produce a more stable, cartilage-like tissue. In addition, we explore potential molecular mechanisms responsible for these phenotypic changes in MSCs." @default.
• W2915393311 created "2019-03-02" @default.
• W2915393311 creator A5014770050 @default.
• W2915393311 creator A5022722737 @default.
• W2915393311 creator A5026651731 @default.
• W2915393311 creator A5037756788 @default.
• W2915393311 creator A5039534172 @default.
• W2915393311 creator A5045482826 @default.
• W2915393311 creator A5063000923 @default.
• W2915393311 creator A5066184840 @default.
• W2915393311 creator A5077982600 @default.
• W2915393311 creator A5081151755 @default.
• W2915393311 creator A5082792190 @default.
• W2915393311 date "2019-04-01" @default.
• W2915393311 modified "2023-10-17" @default.
• W2915393311 title "Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells" @default.
• W2915393311 cites W1427363165 @default.
• W2915393311 cites W1596539624 @default.
• W2915393311 cites W1607020431 @default.
• W2915393311 cites W1701092691 @default.
• W2915393311 cites W1937401270 @default.
• W2915393311 cites W1970576706 @default.
• W2915393311 cites W1970692048 @default.
• W2915393311 cites W1974565328 @default.
• W2915393311 cites W1996087228 @default.
• W2915393311 cites W2000847002 @default.
• W2915393311 cites W2001902689 @default.
• W2915393311 cites W2005868568 @default.
• W2915393311 cites W2014105427 @default.
• W2915393311 cites W2021556708 @default.
• W2915393311 cites W2035266548 @default.
• W2915393311 cites W2035653659 @default.
• W2915393311 cites W2040031153 @default.
• W2915393311 cites W2043814008 @default.
• W2915393311 cites W2048227994 @default.
• W2915393311 cites W2049140373 @default.
• W2915393311 cites W2051531880 @default.
• W2915393311 cites W2052295083 @default.
• W2915393311 cites W2052620919 @default.
• W2915393311 cites W2062098061 @default.
• W2915393311 cites W2067716147 @default.
• W2915393311 cites W2075297594 @default.
• W2915393311 cites W2077515150 @default.
• W2915393311 cites W2084037323 @default.
• W2915393311 cites W2087377825 @default.
• W2915393311 cites W2093660394 @default.
• W2915393311 cites W2095562829 @default.
• W2915393311 cites W2095605427 @default.
• W2915393311 cites W2104113751 @default.
• W2915393311 cites W2111602420 @default.
• W2915393311 cites W2113547540 @default.
• W2915393311 cites W2114570899 @default.
• W2915393311 cites W2131978756 @default.
• W2915393311 cites W2143207096 @default.
• W2915393311 cites W2144625075 @default.
• W2915393311 cites W2151776485 @default.
• W2915393311 cites W2151934024 @default.
• W2915393311 cites W2156598924 @default.
• W2915393311 cites W2163284000 @default.
• W2915393311 cites W2177863951 @default.
• W2915393311 cites W2238333901 @default.
• W2915393311 cites W2270498673 @default.
• W2915393311 cites W2275975166 @default.
• W2915393311 cites W2342884774 @default.
• W2915393311 cites W2343938601 @default.
• W2915393311 cites W2420127809 @default.
• W2915393311 cites W2573145185 @default.
• W2915393311 cites W2591358900 @default.
• W2915393311 cites W2743408921 @default.
• W2915393311 cites W2746083334 @default.
• W2915393311 cites W2751573301 @default.
• W2915393311 cites W2800263359 @default.
• W2915393311 doi "https://doi.org/10.1016/j.actbio.2019.02.042" @default.
• W2915393311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30825603" @default.
• W2915393311 hasPublicationYear "2019" @default.
• W2915393311 type Work @default.
• W2915393311 sameAs 2915393311 @default.
• W2915393311 citedByCount "30" @default.
• W2915393311 countsByYear W29153933112019 @default.
• W2915393311 countsByYear W29153933112020 @default.
• W2915393311 countsByYear W29153933112021 @default.
• W2915393311 countsByYear W29153933112022 @default.
• W2915393311 countsByYear W29153933112023 @default.
• W2915393311 crossrefType "journal-article" @default.
• W2915393311 hasAuthorship W2915393311A5014770050 @default.
• W2915393311 hasAuthorship W2915393311A5022722737 @default.
• W2915393311 hasAuthorship W2915393311A5026651731 @default.
• W2915393311 hasAuthorship W2915393311A5037756788 @default.
• W2915393311 hasAuthorship W2915393311A5039534172 @default.
• W2915393311 hasAuthorship W2915393311A5045482826 @default.
• W2915393311 hasAuthorship W2915393311A5063000923 @default.
• W2915393311 hasAuthorship W2915393311A5066184840 @default.
• W2915393311 hasAuthorship W2915393311A5077982600 @default.
• W2915393311 hasAuthorship W2915393311A5081151755 @default.
• W2915393311 hasAuthorship W2915393311A5082792190 @default.
• W2915393311 hasBestOaLocation W29153933111 @default.
• W2915393311 hasConcept C108586683 @default.
• W2915393311 hasConcept C136229726 @default.

• next