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- W2915426780 abstract "Interesterified fats are being widely used by the food industry in an attempt to replace trans fatty acids. The effect of interesterified fats containing palmitic or stearic acids on lipid metabolism and inflammatory signaling pathways in adipose and hepatic tissues was evaluated. Male LDLr-KO mice were fed a high-fat diet containing polyunsaturated (PUFA), palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR), or stearic interesterified (STEAR INTER) fats for 16 weeks. The expression of genes and protein levels involved in lipid metabolism and inflammatory processes in liver and white adipose tissue was determined by quantitative RT-PCR and by Western blot, respectively. The infiltration of inflammatory cells in hepatic and adipose tissues was determined by eosin and hematoxylin, while liver collagen content was determined by Sirius Red staining. Both interesterified fats increased liver collagen content and JNK phosphorylation. Additionally, the STEAR INTER group developed nonalcoholic steatohepatitis (NASH) associated with higher neutrophil infiltration. PALM INTER induced adipose tissue expansion and enlargement of adipocytes. Furthermore, PALM INTER triggered increased IKK phosphorylation and TNFα protein content, conditions associated with the upstream activation of the NFkB signaling pathway. STEAR INTER induced NASH, while PALM INTER triggered hepatic fibrosis and adipocyte hypertrophy with inflammatory response in LDLr-KO mice." @default.
- W2915426780 created "2019-03-02" @default.
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- W2915426780 date "2019-02-22" @default.
- W2915426780 modified "2023-10-16" @default.
- W2915426780 title "Interesterified Fats Induce Deleterious Effects on Adipose Tissue and Liver in LDLr-KO Mice" @default.
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- W2915426780 cites W1904256740 @default.
- W2915426780 cites W1929316401 @default.
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- W2915426780 cites W1964256266 @default.
- W2915426780 cites W1966708424 @default.
- W2915426780 cites W1975969317 @default.
- W2915426780 cites W1978258186 @default.
- W2915426780 cites W1985592156 @default.
- W2915426780 cites W1986988638 @default.
- W2915426780 cites W1989539426 @default.
- W2915426780 cites W1992489770 @default.
- W2915426780 cites W2003755391 @default.
- W2915426780 cites W2005531517 @default.
- W2915426780 cites W2009150178 @default.
- W2915426780 cites W2009922820 @default.
- W2915426780 cites W2010220662 @default.
- W2915426780 cites W2012037560 @default.
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- W2915426780 cites W2017246066 @default.
- W2915426780 cites W2047878936 @default.
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- W2915426780 cites W2289205869 @default.
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- W2915426780 doi "https://doi.org/10.3390/nu11020466" @default.
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