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- W2915448009 abstract "Resveratrol, a natural product with well-known multiple beneficial effects, has been widely used as a bioactive principle for the development of anti-aging topical phytoproducts. These products are usually applied to skin that is often exposed to solar light for a long time, leading to potentially harmful resveratrol derivatives. In this study we investigated the cytotoxicity and genotoxicity of 2,4,6-trihydroxyphenanthrene (THP), derived from trans-resveratrol photochemical isomerization and electrocyclization. To achieve this goal, we used Caulobacter crescentus as the experimental model for evaluating the colony-forming ability and the SOS response induction of cells exposed to THP. DNA-strand breaks and oxidative damage were assessed by the cell-free pCMut plasmid. The obtained data demonstrated that THP induces a cytotoxic and genotoxic effect of THP even at sub-micromolar concentrations, through a pro-oxidant mechanism leading to DNA damage." @default.
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- W2915448009 date "2019-04-01" @default.
- W2915448009 modified "2023-10-17" @default.
- W2915448009 title "2,4,6-Trihydroxyphenanthrene, a trans-resveratrol photoreaction byproduct: First evidences of genotoxic risk" @default.
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- W2915448009 doi "https://doi.org/10.1016/j.phytol.2019.02.025" @default.
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