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• W2915472644 abstract "The Alzheimer's Disease Sequencing Project (ADSP) was established in 2012 as a key initiative to meet the goals of the National Alzheimer's Project ACT (NAPA) to prevent and effectively treat Alzheimer's disease (AD) by 2025. Developed jointly by National Institute on Aging (NIA) and the National Human Genome Research Institute (NHGRI), the aims of the ADSP are to: 1) identify protective genomic variants in older adults at risk for AD, 2) identify new risk variants among AD cases, and 3) examine these factors in multi-ethnic populations to identify therapeutic targets for disease prevention. The ADSP Data Flow Work Group (DFWG) and the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) support data production for the Genomic Center for Alzheimer's Disease (GCAD), sharing and management for the ADSP, and facilitation of data access to the community. Samples are contributed by the AD Genetics Consortium (ADGC) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE). Sample plating and shipping is coordinated by the National Cell Repository for AD (NCRAD). Whole-exome and whole-genome sequencing data were generated by three NHGRI funded Sequencing Centers, processed by GCAD, and quality controlled by the ADSP. The DFWG maintains the ADSP web site, providing study design, cohort information, news releases, and application instructions for accessing ADSP data. The ADSP has completed whole-exome sequencing of 10,939 unrelated cases and controls, whole-genome sequencing of 854 members from 159 families, and whole-genome sequencing of3098 unrelated cases and controls. All newly sequenced genomes are being processed on GRCh38 by GCAD and are expected to be available for public download spring 2018. Accompanying each sample are phenotypes that were harmonized according to ADSP protocols. The DFWG provides support to all ADSP work groups for data related issues, coordinates with NIAGADS and sequencing centers for data transfers, and reviews, posts, and notifies members of new results generated by other work groups. Additional information can be found on the ADSP website (www.niagads.org/adsp)." @default.
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• W2915472644 date "2018-07-01" @default.
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• W2915472644 title "P1‐149: THE ALZHEIMER'S DISEASE SEQUENCING PROJECT (ADSP) DATA UPDATE 2018" @default.
• W2915472644 doi "https://doi.org/10.1016/j.jalz.2018.06.152" @default.
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