FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915479218> ?p ?o ?g. }

• W2915479218 endingPage "320" @default.
• W2915479218 startingPage "310" @default.
• W2915479218 abstract "The tp53-induced glycolysis and apoptosis regulator (TIGAR) protein controls fructose-2, 6- bisphosphate (Fru-2, 6-P2) levels during glucose metabolism and helps maintain nicotinamide adenine dinucleotide phosphate (NADPH) levels to recycle glutathione (GSH), a key intracellular antioxidant. The present study was designed to investigate the apoptosis and autophagy mechanisms via reactive oxygen species (ROS) that underlie TIGAR knockdown in the A549 cell line. To detect the influence of siRNA-TIGAR on A549 lung cancer cells, we performed cell viabilty, colony formation, ROS, and NADPH assays. In addition, Western blotting and real-time polymerase chain reaction (PCR) assays were used to measure protein and mRNA expression levels, respectively. After TIGAR knockdown in A549 cell lines, various assay parameters were analyzed and showed that down-regulation of TIGAR inhibited viability and decreased colony formation. We also demonstrated that TIGAR knockdown induced apoptosis and autophagy, followed by an induction of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and heme oxygenase-1 (HO-1) expression. Furthermore, increased ROS levels and decreased NADPH levels were observed. This study supports our understanding of the possibility of employing TIGAR knockdown in lung cancer cells to enhance apoptosis and autophagy with NF-κB and HO-1 expression and then suggest TIGAR as a potential target for the treatment of lung cancer." @default.
• W2915479218 created "2019-03-02" @default.
• W2915479218 creator A5017328096 @default.
• W2915479218 creator A5066397483 @default.
• W2915479218 date "2019-03-01" @default.
• W2915479218 modified "2023-10-14" @default.
• W2915479218 title "Knockdown of TIGAR Induces Apoptosis and Autophagy with Modulates NF-κB and HO-1 Expression in A549 Lung Cancer Cells" @default.
• W2915479218 cites W1595404534 @default.
• W2915479218 cites W1967291007 @default.
• W2915479218 cites W1977918575 @default.
• W2915479218 cites W1977930150 @default.
• W2915479218 cites W1982174124 @default.
• W2915479218 cites W1984543978 @default.
• W2915479218 cites W1986391901 @default.
• W2915479218 cites W2011608072 @default.
• W2915479218 cites W2013747211 @default.
• W2915479218 cites W2016468663 @default.
• W2915479218 cites W2026117909 @default.
• W2915479218 cites W2039220817 @default.
• W2915479218 cites W2046595267 @default.
• W2915479218 cites W2064039900 @default.
• W2915479218 cites W2066371867 @default.
• W2915479218 cites W2070897231 @default.
• W2915479218 cites W2072549244 @default.
• W2915479218 cites W2073819646 @default.
• W2915479218 cites W2082221119 @default.
• W2915479218 cites W2084085176 @default.
• W2915479218 cites W2086667809 @default.
• W2915479218 cites W2104471136 @default.
• W2915479218 cites W2107277218 @default.
• W2915479218 cites W2116240218 @default.
• W2915479218 cites W2117840705 @default.
• W2915479218 cites W2117960515 @default.
• W2915479218 cites W2119239003 @default.
• W2915479218 cites W2160295920 @default.
• W2915479218 cites W2163409417 @default.
• W2915479218 cites W2163981813 @default.
• W2915479218 cites W2200781451 @default.
• W2915479218 cites W2555410456 @default.
• W2915479218 cites W2605255264 @default.
• W2915479218 cites W2607465958 @default.
• W2915479218 cites W2614646550 @default.
• W2915479218 doi "https://doi.org/10.21597/jist.446068" @default.
• W2915479218 hasPublicationYear "2019" @default.
• W2915479218 type Work @default.
• W2915479218 sameAs 2915479218 @default.
• W2915479218 citedByCount "0" @default.
• W2915479218 crossrefType "journal-article" @default.
• W2915479218 hasAuthorship W2915479218A5017328096 @default.
• W2915479218 hasAuthorship W2915479218A5066397483 @default.
• W2915479218 hasBestOaLocation W29154792181 @default.
• W2915479218 hasConcept C153911025 @default.
• W2915479218 hasConcept C173396325 @default.
• W2915479218 hasConcept C185592680 @default.
• W2915479218 hasConcept C190283241 @default.
• W2915479218 hasConcept C203522944 @default.
• W2915479218 hasConcept C48349386 @default.
• W2915479218 hasConcept C53227056 @default.
• W2915479218 hasConcept C55493867 @default.
• W2915479218 hasConcept C81729549 @default.
• W2915479218 hasConcept C86803240 @default.
• W2915479218 hasConcept C95444343 @default.
• W2915479218 hasConceptScore W2915479218C153911025 @default.
• W2915479218 hasConceptScore W2915479218C173396325 @default.
• W2915479218 hasConceptScore W2915479218C185592680 @default.
• W2915479218 hasConceptScore W2915479218C190283241 @default.
• W2915479218 hasConceptScore W2915479218C203522944 @default.
• W2915479218 hasConceptScore W2915479218C48349386 @default.
• W2915479218 hasConceptScore W2915479218C53227056 @default.
• W2915479218 hasConceptScore W2915479218C55493867 @default.
• W2915479218 hasConceptScore W2915479218C81729549 @default.
• W2915479218 hasConceptScore W2915479218C86803240 @default.
• W2915479218 hasConceptScore W2915479218C95444343 @default.
• W2915479218 hasIssue "1" @default.
• W2915479218 hasLocation W29154792181 @default.
• W2915479218 hasLocation W29154792182 @default.
• W2915479218 hasOpenAccess W2915479218 @default.
• W2915479218 hasPrimaryLocation W29154792181 @default.
• W2915479218 hasRelatedWork W2002675829 @default.
• W2915479218 hasRelatedWork W2044349121 @default.
• W2915479218 hasRelatedWork W2082336200 @default.
• W2915479218 hasRelatedWork W2358093895 @default.
• W2915479218 hasRelatedWork W2380729234 @default.
• W2915479218 hasRelatedWork W2390045805 @default.
• W2915479218 hasRelatedWork W2440061591 @default.
• W2915479218 hasRelatedWork W2763145678 @default.
• W2915479218 hasRelatedWork W2805121851 @default.
• W2915479218 hasRelatedWork W3139281188 @default.
• W2915479218 hasVolume "9" @default.
• W2915479218 isParatext "false" @default.
• W2915479218 isRetracted "false" @default.
• W2915479218 magId "2915479218" @default.
• W2915479218 workType "article" @default.