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- W2915511394 abstract "Monolluma quadrangula is a succulent bush traditionally used to treat diabetes and peptic ulcer. The present study aimed to investigate the effect of M. quadrangula hydroethanolic extract on glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, lipid profile, and adiponectin expression in type 2 diabetic rats. In addition, the study evaluated the antioxidant and anti-inflammatory activities of the M. quadrangula extract. Type 2 diabetes was induced by feeding rats a high-fat diet (HFD) for 8 weeks followed by 30 mg/kg streptozotocin (STZ). Diabetic rats received 300 or 600 mg/kg M. quadrangula extract for 4 weeks. HFD/STZ diabetic rats showed impaired glucose tolerance, reduced insulin secretion, and insulin resistance. HFD and STZ induced a significant increase in serum cholesterol, triglycerides and proinflammatory cytokines, and liver lipid peroxidation. Treatment with M. quadrangula extract ameliorated these metabolic disturbances and increased liver glycogen, hexokinase activity, and antioxidants. M. quadrangula declined the activity of liver glucose-6-phosphatase and fructose-1,6-biphosphatase. In addition, M. quadrangula extract increased serum adiponectin levels and hepatic adiponectin expression in HFD/STZ diabetic rats. In conclusion, M. quadrangula exerts antidiabetic effect mediated via ameliorating glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, and antioxidant defenses. Increased adiponectin levels and expression seems to mediate, at least in part, the antidiabetic effect of M. quadrangula ." @default.
- W2915511394 created "2019-03-02" @default.
- W2915511394 creator A5061322973 @default.
- W2915511394 date "2019-02-19" @default.
- W2915511394 modified "2023-10-18" @default.
- W2915511394 title "Antidiabetic Effect of<i>Monolluma quadrangula</i>Is Mediated<i>via</i>Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats" @default.
- W2915511394 cites W100496713 @default.
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- W2915511394 cites W1990089345 @default.
- W2915511394 cites W1990840335 @default.
- W2915511394 cites W1994650650 @default.
- W2915511394 cites W2002337520 @default.
- W2915511394 cites W2004616994 @default.
- W2915511394 cites W2010188590 @default.
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- W2915511394 cites W2024144587 @default.
- W2915511394 cites W2025062210 @default.
- W2915511394 cites W2026651349 @default.
- W2915511394 cites W2038138462 @default.
- W2915511394 cites W2042706232 @default.
- W2915511394 cites W2050900577 @default.
- W2915511394 cites W2059652342 @default.
- W2915511394 cites W2069497802 @default.
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- W2915511394 doi "https://doi.org/10.1155/2019/6290143" @default.
- W2915511394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6399546" @default.
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