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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915657419> ?p ?o ?g. }

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• W2915657419 abstract "Muco-obstructive lung diseases feature extensive bronchiectasis due to the uncontrolled release of neutrophil serine proteases into the airways. To assess if cathepsin G (CG) is a novel key player in chronic lung inflammation, we developed membrane-bound (mSAM) and soluble (sSAM) FRET reporters. The probes quantitatively revealed elevated CG activity in samples from 46 patients. For future basic science and personalized clinical applications, we developed a rapid, highly informative, and easily translatable small-molecule FRET flow cytometry assay for monitoring protease activity including cathepsin G. We demonstrated that mSAM distinguished healthy from patient cells by FRET-based flow cytometry with excellent correlation to confocal microscopy data." @default.
• W2915657419 created "2019-03-02" @default.
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• W2915657419 date "2019-02-19" @default.
• W2915657419 modified "2023-10-18" @default.
• W2915657419 title "Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry" @default.
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• W2915657419 doi "https://doi.org/10.1021/acscentsci.8b00933" @default.
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