FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915669318> ?p ?o ?g. }

• W2915669318 endingPage "387" @default.
• W2915669318 startingPage "380" @default.
• W2915669318 abstract "Mass spectrometry-based metabolomics is characterized by a vast number of variables leading to a great degree of complexity. In this work, we aimed to simplify this process with a stepped chemometric optimization of the both funnel technology (funnel exit DC, FDC; funnel RF LP, FLC; funnel RF HP, FRP) and ion source parameters (Octopolo, Oct; and Fragmentor, Frag) of a quadrupole-time of flight (qTOF) for a human urinary metabolites. The workflow comprised a Box-Behnken experimental design with 47 experiments followed by the identification and quantification of a set of metabolites using high-resolution full-scan MS mode and feature extraction with an inclusion list. Metabolite peak areas were grouped according to abundance (high and low) and modeled by Random Forest regression (variance explained >85%). The full three-level factorial design consisting in 243 experiments was predicted and top 10 solutions for desirability function and those comprising the Pareto front were extracted and investigated. To guarantee the quality of results, we compared the Pareto front solutions with those achieved by standard instrumental parameters suggested by the manufacturer. A set of five solutions were identified that increased the mean peak area by 56-59% and 17%, for high- and low-abundance metabolites, respectively. The optimal parameters were determined to be: FLP, 100 V; FDC, 40 and 30 V; Frag, 275 and 400 V; and Oct, 600 and 800 V. The methodology applied throughout this work represents a flexible strategy to optimize instrumental parameters and exploit the performance of a qTOF MS detector." @default.
• W2915669318 created "2019-03-02" @default.
• W2915669318 creator A5025354968 @default.
• W2915669318 creator A5029435917 @default.
• W2915669318 creator A5040649064 @default.
• W2915669318 creator A5071278282 @default.
• W2915669318 creator A5075106792 @default.
• W2915669318 date "2019-07-01" @default.
• W2915669318 modified "2023-09-29" @default.
• W2915669318 title "Chemometrics-assisted optimization of liquid chromatography-quadrupole-time-of-flight mass spectrometry analysis for targeted metabolomics" @default.
• W2915669318 cites W1484658745 @default.
• W2915669318 cites W1574010145 @default.
• W2915669318 cites W1951097775 @default.
• W2915669318 cites W1965258535 @default.
• W2915669318 cites W1969382956 @default.
• W2915669318 cites W1971606140 @default.
• W2915669318 cites W1984597404 @default.
• W2915669318 cites W1990653740 @default.
• W2915669318 cites W1996209745 @default.
• W2915669318 cites W2000126509 @default.
• W2915669318 cites W2001265990 @default.
• W2915669318 cites W2006901874 @default.
• W2915669318 cites W2020732355 @default.
• W2915669318 cites W2030677000 @default.
• W2915669318 cites W2032617433 @default.
• W2915669318 cites W2033129567 @default.
• W2915669318 cites W2045256553 @default.
• W2915669318 cites W2054476298 @default.
• W2915669318 cites W2064988047 @default.
• W2915669318 cites W2066947166 @default.
• W2915669318 cites W2079843936 @default.
• W2915669318 cites W2085281262 @default.
• W2915669318 cites W2088376206 @default.
• W2915669318 cites W2094835462 @default.
• W2915669318 cites W2124003155 @default.
• W2915669318 cites W2126105956 @default.
• W2915669318 cites W2176790965 @default.
• W2915669318 cites W2296118565 @default.
• W2915669318 cites W2322504283 @default.
• W2915669318 cites W2334343253 @default.
• W2915669318 cites W2581320133 @default.
• W2915669318 cites W2616397165 @default.
• W2915669318 cites W2795447667 @default.
• W2915669318 cites W2802654117 @default.
• W2915669318 cites W2911964244 @default.
• W2915669318 cites W768171911 @default.
• W2915669318 doi "https://doi.org/10.1016/j.talanta.2019.02.075" @default.
• W2915669318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30952273" @default.
• W2915669318 hasPublicationYear "2019" @default.
• W2915669318 type Work @default.
• W2915669318 sameAs 2915669318 @default.
• W2915669318 citedByCount "8" @default.
• W2915669318 countsByYear W29156693182019 @default.
• W2915669318 countsByYear W29156693182020 @default.
• W2915669318 countsByYear W29156693182021 @default.
• W2915669318 countsByYear W29156693182022 @default.
• W2915669318 crossrefType "journal-article" @default.
• W2915669318 hasAuthorship W2915669318A5025354968 @default.
• W2915669318 hasAuthorship W2915669318A5029435917 @default.
• W2915669318 hasAuthorship W2915669318A5040649064 @default.
• W2915669318 hasAuthorship W2915669318A5071278282 @default.
• W2915669318 hasAuthorship W2915669318A5075106792 @default.
• W2915669318 hasConcept C105795698 @default.
• W2915669318 hasConcept C113196181 @default.
• W2915669318 hasConcept C151304367 @default.
• W2915669318 hasConcept C162356407 @default.
• W2915669318 hasConcept C16469947 @default.
• W2915669318 hasConcept C169222746 @default.
• W2915669318 hasConcept C17435862 @default.
• W2915669318 hasConcept C178790620 @default.
• W2915669318 hasConcept C185592680 @default.
• W2915669318 hasConcept C186060115 @default.
• W2915669318 hasConcept C21565614 @default.
• W2915669318 hasConcept C33923547 @default.
• W2915669318 hasConcept C34559072 @default.
• W2915669318 hasConcept C43617362 @default.
• W2915669318 hasConcept C86803240 @default.
• W2915669318 hasConceptScore W2915669318C105795698 @default.
• W2915669318 hasConceptScore W2915669318C113196181 @default.
• W2915669318 hasConceptScore W2915669318C151304367 @default.
• W2915669318 hasConceptScore W2915669318C162356407 @default.
• W2915669318 hasConceptScore W2915669318C16469947 @default.
• W2915669318 hasConceptScore W2915669318C169222746 @default.
• W2915669318 hasConceptScore W2915669318C17435862 @default.
• W2915669318 hasConceptScore W2915669318C178790620 @default.
• W2915669318 hasConceptScore W2915669318C185592680 @default.
• W2915669318 hasConceptScore W2915669318C186060115 @default.
• W2915669318 hasConceptScore W2915669318C21565614 @default.
• W2915669318 hasConceptScore W2915669318C33923547 @default.
• W2915669318 hasConceptScore W2915669318C34559072 @default.
• W2915669318 hasConceptScore W2915669318C43617362 @default.
• W2915669318 hasConceptScore W2915669318C86803240 @default.
• W2915669318 hasLocation W29156693181 @default.
• W2915669318 hasLocation W29156693182 @default.
• W2915669318 hasOpenAccess W2915669318 @default.
• W2915669318 hasPrimaryLocation W29156693181 @default.
• W2915669318 hasRelatedWork W1976529163 @default.
• W2915669318 hasRelatedWork W2042686380 @default.

• next