FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915669600> ?p ?o ?g. }

• W2915669600 endingPage "13533" @default.
• W2915669600 startingPage "13525" @default.
• W2915669600 abstract "Osteosarcoma, including spinal osteosarcoma, has properties of high degree of malignancy, high rate of recurrence, and high incidence of metastasis. microRNAs can exert oncogenic or tumor suppressive roles in cancer cells. This study explored the effects of microRNA-493-5p (miR-493-5p) on osteosarcoma cell viability, migration, invasion, and apoptosis, as well as the underlying possible mechanism. First, the expression of miR-493-5p in osteosarcoma tissues and cells was detected using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Then, the effects of miR-493-5p overexpression (or suppression) on osteosarcoma cell viability, migration, invasion, and apoptosis, as well as Kruppel-like factor 5 (KLF5) expression, were assessed using the Cell Counting Kit-8 assay, two-chamber transwell assay, Annexin V-FITC/PI apoptosis detection kit, qRT-PCR, and western blotting, respectively. Finally, the roles of KLF5 in miR-493-5p suppression-induced U20S cell viability, migration, and invasion enhancement, as well as the PI3K/AKT pathway activation, were evaluated. We found that miR-493-5p had lower expression in tumor tissues of spinal osteosarcoma and osteosarcoma cells. Overexpression of miR-493-5p inhibited osteosarcoma U20S cell viability, migration, and invasion, but induced cell apoptosis. On the contrary, suppression of miR-493-5p-promoted U20S cell viability, migration, and invasion. KLF5 was a direct target gene of miR-493-5p, which participated in the effects of miR-493-5p on U20S cell viability, migration, invasion, and apoptosis. Furthermore, suppression of the miR-493-5p activated PI3K/AKT pathway in U20S cells by upregulating KLF5. In conclusion, we revealed that miR-493-5p exerted tumor suppressive roles in spinal osteosarcoma and osteosarcoma cells. Overexpression of miR-493-5p inhibited proliferation and metastasis of osteosarcoma cells by downregulating KLF5 and inactivating the PI3K/AKT signaling pathway." @default.
• W2915669600 created "2019-03-02" @default.
• W2915669600 creator A5009181954 @default.
• W2915669600 creator A5014091323 @default.
• W2915669600 creator A5022144606 @default.
• W2915669600 creator A5037804142 @default.
• W2915669600 creator A5071686064 @default.
• W2915669600 creator A5079339963 @default.
• W2915669600 date "2019-02-17" @default.
• W2915669600 modified "2023-09-29" @default.
• W2915669600 title "<i>Retracted</i> : MicroRNA‐493‐5p inhibits proliferation and metastasis of osteosarcoma cells by targeting Kruppel‐like factor 5" @default.
• W2915669600 cites W125097236 @default.
• W2915669600 cites W1541084139 @default.
• W2915669600 cites W1928460987 @default.
• W2915669600 cites W1968792907 @default.
• W2915669600 cites W1981014348 @default.
• W2915669600 cites W1989193425 @default.
• W2915669600 cites W2106291049 @default.
• W2915669600 cites W2138975873 @default.
• W2915669600 cites W2275259182 @default.
• W2915669600 cites W2291047705 @default.
• W2915669600 cites W2325539996 @default.
• W2915669600 cites W2424509516 @default.
• W2915669600 cites W2515781164 @default.
• W2915669600 cites W2577936564 @default.
• W2915669600 cites W2592550824 @default.
• W2915669600 cites W2606984636 @default.
• W2915669600 cites W2607348651 @default.
• W2915669600 cites W2609764113 @default.
• W2915669600 cites W2613006951 @default.
• W2915669600 cites W2738528174 @default.
• W2915669600 cites W2768013728 @default.
• W2915669600 cites W2770001929 @default.
• W2915669600 cites W2782799955 @default.
• W2915669600 cites W2782834470 @default.
• W2915669600 cites W2790328757 @default.
• W2915669600 cites W2807398426 @default.
• W2915669600 cites W282221905 @default.
• W2915669600 cites W4211062330 @default.
• W2915669600 cites W4236473576 @default.
• W2915669600 doi "https://doi.org/10.1002/jcp.28030" @default.
• W2915669600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30773645" @default.
• W2915669600 hasPublicationYear "2019" @default.
• W2915669600 type Work @default.
• W2915669600 sameAs 2915669600 @default.
• W2915669600 citedByCount "28" @default.
• W2915669600 countsByYear W29156696002019 @default.
• W2915669600 countsByYear W29156696002020 @default.
• W2915669600 countsByYear W29156696002021 @default.
• W2915669600 countsByYear W29156696002022 @default.
• W2915669600 countsByYear W29156696002023 @default.
• W2915669600 crossrefType "journal-article" @default.
• W2915669600 hasAuthorship W2915669600A5009181954 @default.
• W2915669600 hasAuthorship W2915669600A5014091323 @default.
• W2915669600 hasAuthorship W2915669600A5022144606 @default.
• W2915669600 hasAuthorship W2915669600A5037804142 @default.
• W2915669600 hasAuthorship W2915669600A5071686064 @default.
• W2915669600 hasAuthorship W2915669600A5079339963 @default.
• W2915669600 hasConcept C104317684 @default.
• W2915669600 hasConcept C11957725 @default.
• W2915669600 hasConcept C121608353 @default.
• W2915669600 hasConcept C137738243 @default.
• W2915669600 hasConcept C145059251 @default.
• W2915669600 hasConcept C1491633281 @default.
• W2915669600 hasConcept C185592680 @default.
• W2915669600 hasConcept C190283241 @default.
• W2915669600 hasConcept C2777760704 @default.
• W2915669600 hasConcept C2779013556 @default.
• W2915669600 hasConcept C502942594 @default.
• W2915669600 hasConcept C53227056 @default.
• W2915669600 hasConcept C54355233 @default.
• W2915669600 hasConcept C55493867 @default.
• W2915669600 hasConcept C62112901 @default.
• W2915669600 hasConcept C75217442 @default.
• W2915669600 hasConcept C86554907 @default.
• W2915669600 hasConcept C86803240 @default.
• W2915669600 hasConceptScore W2915669600C104317684 @default.
• W2915669600 hasConceptScore W2915669600C11957725 @default.
• W2915669600 hasConceptScore W2915669600C121608353 @default.
• W2915669600 hasConceptScore W2915669600C137738243 @default.
• W2915669600 hasConceptScore W2915669600C145059251 @default.
• W2915669600 hasConceptScore W2915669600C1491633281 @default.
• W2915669600 hasConceptScore W2915669600C185592680 @default.
• W2915669600 hasConceptScore W2915669600C190283241 @default.
• W2915669600 hasConceptScore W2915669600C2777760704 @default.
• W2915669600 hasConceptScore W2915669600C2779013556 @default.
• W2915669600 hasConceptScore W2915669600C502942594 @default.
• W2915669600 hasConceptScore W2915669600C53227056 @default.
• W2915669600 hasConceptScore W2915669600C54355233 @default.
• W2915669600 hasConceptScore W2915669600C55493867 @default.
• W2915669600 hasConceptScore W2915669600C62112901 @default.
• W2915669600 hasConceptScore W2915669600C75217442 @default.
• W2915669600 hasConceptScore W2915669600C86554907 @default.
• W2915669600 hasConceptScore W2915669600C86803240 @default.
• W2915669600 hasIssue "8" @default.
• W2915669600 hasLocation W29156696001 @default.
• W2915669600 hasLocation W29156696002 @default.
• W2915669600 hasOpenAccess W2915669600 @default.

• next