FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915675088> ?p ?o ?g. }

• W2915675088 endingPage "467" @default.
• W2915675088 startingPage "460" @default.
• W2915675088 abstract "Methylmercury (MeHg) is a highly toxic pollutant, and is considered hazardous to human health. In our previous study, we found that MeHg induces autophagy and that Atg5-dependent autophagy plays a protective role against MeHg toxicity. To further characterize the role of autophagy in MeHg-induced toxicity, we examined the impact of autophagy on microtubules and nuclei under MeHg exposure using Atg5KO mouse embryonic fibroblasts (MEFs). Low concentrations of MeHg induced a decrease in α-tubulin and acetylated-tubulin in both wild-type and Atg5KO cells. While α-tubulin acetylation was promoted by treatment with tubacin, a selective inhibitor of histone deacetylase 6, MeHg treatment inhibits the increase of tubacin-induced acetylated-tubulin. However, similar effects were observed for treatment with either tubacin or tubacin + MeHg in wild-type and Atg5KO cells. We also found a significant increase in the number of multinuclear cells upon MeHg exposure in Atg5KO MEFs compared to wild-type MEFs. In addition, DNA double strand breaks (DSBs), measured by phosphorylation of the core histone H2A variant (H2AX) on serine 139 (γH2AX), markedly increased in Atg5KO MEFs compared to wild-type MEFs. Our results therefore suggest that autophagy is not a simple elimination pathway of MeHg-induced damaged proteins, but that it also plays a protective role in the context of MeHg-associated DSBs." @default.
• W2915675088 created "2019-03-02" @default.
• W2915675088 creator A5021701889 @default.
• W2915675088 creator A5045675390 @default.
• W2915675088 creator A5065148849 @default.
• W2915675088 creator A5073284990 @default.
• W2915675088 creator A5087708346 @default.
• W2915675088 date "2019-04-01" @default.
• W2915675088 modified "2023-10-18" @default.
• W2915675088 title "An autophagy deficiency promotes methylmercury-induced multinuclear cell formation" @default.
• W2915675088 cites W1023820744 @default.
• W2915675088 cites W1566724399 @default.
• W2915675088 cites W1985907733 @default.
• W2915675088 cites W1986585424 @default.
• W2915675088 cites W1987106543 @default.
• W2915675088 cites W1989049847 @default.
• W2915675088 cites W1991042350 @default.
• W2915675088 cites W1992432768 @default.
• W2915675088 cites W2001591494 @default.
• W2915675088 cites W2004926855 @default.
• W2915675088 cites W2013193887 @default.
• W2915675088 cites W2019711905 @default.
• W2915675088 cites W2022725699 @default.
• W2915675088 cites W2037824524 @default.
• W2915675088 cites W2038875766 @default.
• W2915675088 cites W2044621729 @default.
• W2915675088 cites W2060607011 @default.
• W2915675088 cites W2064959533 @default.
• W2915675088 cites W2066911698 @default.
• W2915675088 cites W2069191801 @default.
• W2915675088 cites W2078003513 @default.
• W2915675088 cites W2078340512 @default.
• W2915675088 cites W2085442981 @default.
• W2915675088 cites W2090815214 @default.
• W2915675088 cites W2093501381 @default.
• W2915675088 cites W2099497015 @default.
• W2915675088 cites W2106782035 @default.
• W2915675088 cites W2116826087 @default.
• W2915675088 cites W2118884969 @default.
• W2915675088 cites W2125497931 @default.
• W2915675088 cites W2155341165 @default.
• W2915675088 cites W2159591471 @default.
• W2915675088 cites W2471420689 @default.
• W2915675088 cites W2520485831 @default.
• W2915675088 cites W2521415488 @default.
• W2915675088 cites W2755528727 @default.
• W2915675088 cites W2770096773 @default.
• W2915675088 doi "https://doi.org/10.1016/j.bbrc.2019.02.084" @default.
• W2915675088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30797556" @default.
• W2915675088 hasPublicationYear "2019" @default.
• W2915675088 type Work @default.
• W2915675088 sameAs 2915675088 @default.
• W2915675088 citedByCount "7" @default.
• W2915675088 countsByYear W29156750882020 @default.
• W2915675088 countsByYear W29156750882021 @default.
• W2915675088 countsByYear W29156750882022 @default.
• W2915675088 countsByYear W29156750882023 @default.
• W2915675088 crossrefType "journal-article" @default.
• W2915675088 hasAuthorship W2915675088A5021701889 @default.
• W2915675088 hasAuthorship W2915675088A5045675390 @default.
• W2915675088 hasAuthorship W2915675088A5065148849 @default.
• W2915675088 hasAuthorship W2915675088A5073284990 @default.
• W2915675088 hasAuthorship W2915675088A5087708346 @default.
• W2915675088 hasConcept C104317684 @default.
• W2915675088 hasConcept C119157956 @default.
• W2915675088 hasConcept C143065580 @default.
• W2915675088 hasConcept C143425029 @default.
• W2915675088 hasConcept C178790620 @default.
• W2915675088 hasConcept C185592680 @default.
• W2915675088 hasConcept C190283241 @default.
• W2915675088 hasConcept C203522944 @default.
• W2915675088 hasConcept C20418707 @default.
• W2915675088 hasConcept C207583985 @default.
• W2915675088 hasConcept C2781000418 @default.
• W2915675088 hasConcept C29730261 @default.
• W2915675088 hasConcept C31573885 @default.
• W2915675088 hasConcept C552990157 @default.
• W2915675088 hasConcept C55493867 @default.
• W2915675088 hasConcept C64927066 @default.
• W2915675088 hasConcept C84425145 @default.
• W2915675088 hasConcept C86803240 @default.
• W2915675088 hasConcept C95444343 @default.
• W2915675088 hasConceptScore W2915675088C104317684 @default.
• W2915675088 hasConceptScore W2915675088C119157956 @default.
• W2915675088 hasConceptScore W2915675088C143065580 @default.
• W2915675088 hasConceptScore W2915675088C143425029 @default.
• W2915675088 hasConceptScore W2915675088C178790620 @default.
• W2915675088 hasConceptScore W2915675088C185592680 @default.
• W2915675088 hasConceptScore W2915675088C190283241 @default.
• W2915675088 hasConceptScore W2915675088C203522944 @default.
• W2915675088 hasConceptScore W2915675088C20418707 @default.
• W2915675088 hasConceptScore W2915675088C207583985 @default.
• W2915675088 hasConceptScore W2915675088C2781000418 @default.
• W2915675088 hasConceptScore W2915675088C29730261 @default.
• W2915675088 hasConceptScore W2915675088C31573885 @default.
• W2915675088 hasConceptScore W2915675088C552990157 @default.
• W2915675088 hasConceptScore W2915675088C55493867 @default.
• W2915675088 hasConceptScore W2915675088C64927066 @default.

• next