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- W2915685783 abstract "Recent studies have shown that circulating levels of plant sterols (campesterol and sitosterol) are markers of cholesterol absorption, while lathosterol, a precursor in the cholesterol synthetic pathway, is a marker for whole body cholesterol synthesis. Endurance exercise training is known to have favorable effects on plasma cholesterol levels, but it is not known if this is mediated in part by changes in rates of cholesterol absorption or synthesis. To examine this, we measured circulating levels of campesterol, sitosterol, and lathosterol by GC/mass spectroscopy from plasma samples of 30 sedentary subjects (20 women, 10 men, average age = 59) before and after 6 months of endurance exercise training. There was no change in sitosterol or lathosterol levels in response to the exercise training intervention. However, there was a trend for an increase in plasma campesterol levels of 20% following the intervention (p = 0.07). Other changes in lipids included the following: there was no change in total or LDL-C levels in response to the exercise intervention; however, HDL-C and the HDL2-C subfraction increased 4.0mg/dL and 2.2mg/dL, respectively (p < .01), and total triglyceride levels decreased by 20mg/dL (p < 0.001). The increase in plasma campesterol indicates that endurance exercise training may have a significant impact on rates of cholesterol absorption. Reduced levels of cholesterol absorption have been linked to the development of the “metabolic syndrome.” As a result, this exercise induced increase in campesterol levels may suggest a previously unrecognized benefit of exercise training on cholesterol metabolism." @default.
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- W2915685783 date "2006-05-01" @default.
- W2915685783 modified "2023-09-25" @default.
- W2915685783 title "Effect of Endurance Exercise Training on Markers of Cholesterol Absorption and Synthesis" @default.
- W2915685783 doi "https://doi.org/10.1249/00005768-200605001-02897" @default.
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