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- W2915691225 abstract "This chapter focuses on reactions of interest in medicinal chemistry. Advances in the use of computers for the design of synthetic schemes are described. Application of computer graphics to input and output chemical structures, the development of a computer program to effectively perceive structural units and relationships, and the use of a computer system to generate a “tree” of possible intermediates starting from a given target molecule are discussed. The facile use of stereoselective hydrocyanation is described. Because the nitrile function can be converted to methyl as well as to a variety of functional groups, the conjugate addition of HCN has wide application. The use of organosulfur compounds in organic syntheses was also reviewed. The bicyclic amidines 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have proven to be superior to pyridine, N,N-dimethylaniline, and other common amines in dehydrohalogenations of very sensitive molecules. A review summarized their use in dehydrohalgenations, condensations, and rearrangements. The α-Chloronitrones were explored as “enophiles” that would undergo 4+2 cycloadditions with isolated olefinic double bonds, even though the double bond is not activated." @default.
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- W2915691225 date "1973-01-01" @default.
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- W2915691225 title "Chapter 31. Reactions of Interest in Medicinal Chemistry" @default.
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- W2915691225 doi "https://doi.org/10.1016/s0065-7743(08)61259-2" @default.
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