Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915705312> ?p ?o ?g. }
- W2915705312 startingPage "555318" @default.
- W2915705312 abstract "Myriad cell types comprise the human neocortex, but their roles in normal brain function and disease are largely unknown because few tools exist. To find enhancer elements useful for cell type-specific genetic tools, we examined chromatin accessibility in >2,800 high-quality single human neocortical nuclei. Accessible elements frequently are conserved in mouse (34%), often overlap with hypomethylated sites (27%), and connect cell types with neurological diseases via trait-associated SNPs. Directly testing these elements in viral vectors demonstrates functional enhancer activity with cell type specificity predicted by their chromatin accessibility patterns. In summary we present a catalog of human cell class-specific epigenetic elements, and utilize them for new species-agnostic cell type-specific viral genetic tools, which will illuminate human neuron function and drive gene therapy applications." @default.
- W2915705312 created "2019-03-02" @default.
- W2915705312 creator A5050240445 @default.
- W2915705312 creator A5053088872 @default.
- W2915705312 date "2019-02-19" @default.
- W2915705312 modified "2023-09-27" @default.
- W2915705312 title "Epigenetic landscape and AAV targeting of human neocortical cell classes" @default.
- W2915705312 cites W1602702667 @default.
- W2915705312 cites W1844405070 @default.
- W2915705312 cites W1947231608 @default.
- W2915705312 cites W1979283544 @default.
- W2915705312 cites W1979612107 @default.
- W2915705312 cites W2014677321 @default.
- W2915705312 cites W2015484447 @default.
- W2915705312 cites W2041171293 @default.
- W2915705312 cites W2060316084 @default.
- W2915705312 cites W2126434800 @default.
- W2915705312 cites W2152642144 @default.
- W2915705312 cites W2153860431 @default.
- W2915705312 cites W2157009395 @default.
- W2915705312 cites W2159213224 @default.
- W2915705312 cites W2167852161 @default.
- W2915705312 cites W2202976683 @default.
- W2915705312 cites W2231058499 @default.
- W2915705312 cites W2256579886 @default.
- W2915705312 cites W2413271074 @default.
- W2915705312 cites W2527794060 @default.
- W2915705312 cites W2529648506 @default.
- W2915705312 cites W2546343095 @default.
- W2915705312 cites W2582412045 @default.
- W2915705312 cites W2708579841 @default.
- W2915705312 cites W2744040456 @default.
- W2915705312 cites W2750049634 @default.
- W2915705312 cites W2767443671 @default.
- W2915705312 cites W2789284185 @default.
- W2915705312 cites W2790732445 @default.
- W2915705312 cites W2802659348 @default.
- W2915705312 cites W2808199143 @default.
- W2915705312 cites W2810164974 @default.
- W2915705312 cites W2883810206 @default.
- W2915705312 cites W2887910040 @default.
- W2915705312 cites W2909412037 @default.
- W2915705312 cites W2919724853 @default.
- W2915705312 cites W2920682232 @default.
- W2915705312 cites W2920869384 @default.
- W2915705312 cites W2937879464 @default.
- W2915705312 cites W2950244010 @default.
- W2915705312 cites W2950976066 @default.
- W2915705312 cites W2952582936 @default.
- W2915705312 cites W2952602120 @default.
- W2915705312 cites W2952673268 @default.
- W2915705312 cites W2956118984 @default.
- W2915705312 cites W2969948459 @default.
- W2915705312 cites W2970759956 @default.
- W2915705312 cites W2979165129 @default.
- W2915705312 cites W2988958689 @default.
- W2915705312 cites W2998795963 @default.
- W2915705312 cites W3005243489 @default.
- W2915705312 cites W3103169424 @default.
- W2915705312 cites W3105513797 @default.
- W2915705312 hasPublicationYear "2019" @default.
- W2915705312 type Work @default.
- W2915705312 sameAs 2915705312 @default.
- W2915705312 citedByCount "2" @default.
- W2915705312 countsByYear W29157053122019 @default.
- W2915705312 countsByYear W29157053122021 @default.
- W2915705312 crossrefType "posted-content" @default.
- W2915705312 hasAuthorship W2915705312A5050240445 @default.
- W2915705312 hasAuthorship W2915705312A5053088872 @default.
- W2915705312 hasBestOaLocation W29157053121 @default.
- W2915705312 hasConcept C104317684 @default.
- W2915705312 hasConcept C111936080 @default.
- W2915705312 hasConcept C14036430 @default.
- W2915705312 hasConcept C1491633281 @default.
- W2915705312 hasConcept C150194340 @default.
- W2915705312 hasConcept C169760540 @default.
- W2915705312 hasConcept C189014844 @default.
- W2915705312 hasConcept C2777222312 @default.
- W2915705312 hasConcept C2988867146 @default.
- W2915705312 hasConcept C41091548 @default.
- W2915705312 hasConcept C54355233 @default.
- W2915705312 hasConcept C70721500 @default.
- W2915705312 hasConcept C83640560 @default.
- W2915705312 hasConcept C86803240 @default.
- W2915705312 hasConceptScore W2915705312C104317684 @default.
- W2915705312 hasConceptScore W2915705312C111936080 @default.
- W2915705312 hasConceptScore W2915705312C14036430 @default.
- W2915705312 hasConceptScore W2915705312C1491633281 @default.
- W2915705312 hasConceptScore W2915705312C150194340 @default.
- W2915705312 hasConceptScore W2915705312C169760540 @default.
- W2915705312 hasConceptScore W2915705312C189014844 @default.
- W2915705312 hasConceptScore W2915705312C2777222312 @default.
- W2915705312 hasConceptScore W2915705312C2988867146 @default.
- W2915705312 hasConceptScore W2915705312C41091548 @default.
- W2915705312 hasConceptScore W2915705312C54355233 @default.
- W2915705312 hasConceptScore W2915705312C70721500 @default.
- W2915705312 hasConceptScore W2915705312C83640560 @default.
- W2915705312 hasConceptScore W2915705312C86803240 @default.
- W2915705312 hasLocation W29157053121 @default.