FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915839774> ?p ?o ?g. }

• W2915839774 endingPage "725" @default.
• W2915839774 startingPage "715" @default.
• W2915839774 abstract "Spirocyclic tetramic acids are widely used in controlling phytophagous mite species throughout the world. the data set is incomplete and provides insufficient evidence for drawing the same conclusion for fish. To fill the gap whether these acaricides alter lipid metabolism on vertebrates, zebrafish embryos exposed to a series concentration of pesticides, the developmental effects, enzyme activities and levels of gene expression were assessed, battery of biomarker utilized by the integrated biomarker response (IBRv2) model. The 96 h-LC50 of spirodiclofen, spiromesifen and spirotetramat were 0.14, 0.12 and 5.94 mg/L, respectively. Yolk sac deformity, pericardial edema, spinal curvature and tail malformation were observed. Three spirocyclic acids were unfavouring the lipid accumulation of by inhibited the acetyl-CoA carboxylase (ACC), fatty acid synthesis (FAS), fatty acid binding proteins (FABP2) and lipoprotein lipase (LPL) activity. The total cholesterol (TCHO) level significantly decreased in the 0.072 mg/L spirodiclofen group and 0.015 and 0.030 mg/L in the spiromesifen groups. No expected change in spirotetramat group on the TCHO and triglycerides (TGs) levels for any of the treatments. The mRNA levels of the genes related to lipid metabolism also significantly altered. In both spirodiclofen and spiromesifen, ACC achieved the highest scores among a battery of biomarkers using integrated biomarker response (IBRv2). The results suggest that spiromesifen was the most toxic for embryos development and spirodiclofen was the most toxic for lipid metabolism in embryos. The 0.07 mg/L of spirodiclofen, 0.05 mg/L of spiromesifen and 2.00 mg/L would cause malformation on zebrafish embryos. This study will provide new insight that fatty acid metabolism may be a suitable biomarker for the spirocyclic tetramic acids in fish species." @default.
• W2915839774 created "2019-03-02" @default.
• W2915839774 creator A5003098842 @default.
• W2915839774 creator A5004179735 @default.
• W2915839774 creator A5011799368 @default.
• W2915839774 creator A5018946004 @default.
• W2915839774 creator A5051862250 @default.
• W2915839774 creator A5056533320 @default.
• W2915839774 creator A5063685246 @default.
• W2915839774 creator A5073501391 @default.
• W2915839774 creator A5074925607 @default.
• W2915839774 creator A5085096726 @default.
• W2915839774 creator A5087645836 @default.
• W2915839774 date "2019-05-01" @default.
• W2915839774 modified "2023-10-16" @default.
• W2915839774 title "The lipid metabolism alteration of three spirocyclic tetramic acids on zebrafish (Danio rerio) embryos" @default.
• W2915839774 cites W1564861448 @default.
• W2915839774 cites W1947928390 @default.
• W2915839774 cites W1968703258 @default.
• W2915839774 cites W1974022535 @default.
• W2915839774 cites W1978183322 @default.
• W2915839774 cites W2003859756 @default.
• W2915839774 cites W2005317793 @default.
• W2915839774 cites W2009240729 @default.
• W2915839774 cites W2012007076 @default.
• W2915839774 cites W2014259643 @default.
• W2915839774 cites W2023607102 @default.
• W2915839774 cites W2028489790 @default.
• W2915839774 cites W2029598860 @default.
• W2915839774 cites W2031646436 @default.
• W2915839774 cites W2033823674 @default.
• W2915839774 cites W2038364461 @default.
• W2915839774 cites W2040080791 @default.
• W2915839774 cites W2040565479 @default.
• W2915839774 cites W2042184384 @default.
• W2915839774 cites W2044954122 @default.
• W2915839774 cites W2047369469 @default.
• W2915839774 cites W2049406893 @default.
• W2915839774 cites W2051050022 @default.
• W2915839774 cites W2054849175 @default.
• W2915839774 cites W2060715824 @default.
• W2915839774 cites W2063626539 @default.
• W2915839774 cites W2071181652 @default.
• W2915839774 cites W2078434599 @default.
• W2915839774 cites W2085465461 @default.
• W2915839774 cites W2085813777 @default.
• W2915839774 cites W2086687144 @default.
• W2915839774 cites W2088188319 @default.
• W2915839774 cites W2089158765 @default.
• W2915839774 cites W2091258310 @default.
• W2915839774 cites W2094788334 @default.
• W2915839774 cites W2099635142 @default.
• W2915839774 cites W2110553209 @default.
• W2915839774 cites W2113328569 @default.
• W2915839774 cites W2117488455 @default.
• W2915839774 cites W2121348741 @default.
• W2915839774 cites W2121936687 @default.
• W2915839774 cites W2121960635 @default.
• W2915839774 cites W2122968792 @default.
• W2915839774 cites W2125349610 @default.
• W2915839774 cites W2126218858 @default.
• W2915839774 cites W2129205142 @default.
• W2915839774 cites W2129209158 @default.
• W2915839774 cites W2134567873 @default.
• W2915839774 cites W2134721290 @default.
• W2915839774 cites W2145855403 @default.
• W2915839774 cites W2149174371 @default.
• W2915839774 cites W2164172223 @default.
• W2915839774 cites W2171545684 @default.
• W2915839774 cites W2261856734 @default.
• W2915839774 cites W2314778427 @default.
• W2915839774 cites W2502818374 @default.
• W2915839774 cites W2542930363 @default.
• W2915839774 cites W2589135608 @default.
• W2915839774 cites W2756295987 @default.
• W2915839774 cites W2763829091 @default.
• W2915839774 cites W2778314063 @default.
• W2915839774 cites W2785218563 @default.
• W2915839774 cites W2793037742 @default.
• W2915839774 cites W2793792389 @default.
• W2915839774 cites W2795340584 @default.
• W2915839774 cites W2796109241 @default.
• W2915839774 cites W2796784848 @default.
• W2915839774 cites W2805341990 @default.
• W2915839774 cites W2808711807 @default.
• W2915839774 cites W2809821652 @default.
• W2915839774 cites W2885919051 @default.
• W2915839774 cites W4231637732 @default.
• W2915839774 cites W658237353 @default.
• W2915839774 cites W2753308801 @default.
• W2915839774 doi "https://doi.org/10.1016/j.envpol.2019.02.035" @default.
• W2915839774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30849589" @default.
• W2915839774 hasPublicationYear "2019" @default.
• W2915839774 type Work @default.
• W2915839774 sameAs 2915839774 @default.
• W2915839774 citedByCount "21" @default.
• W2915839774 countsByYear W29158397742019 @default.
• W2915839774 countsByYear W29158397742020 @default.

• next