Matches in SemOpenAlex for { <https://semopenalex.org/work/W2915958320> ?p ?o ?g. }
- W2915958320 endingPage "528" @default.
- W2915958320 startingPage "513" @default.
- W2915958320 abstract "Objectives: Childhood emotional neglect (EN) is a predictor for the development of affective disorders. Oxytocin (OXT) may mediate the interplay between EN and changes in stress biological systems, brain development, and mental health outcomes. We investigated, in a cross-sectional study, the associations between EN, (epi)genetic variation in the OXT receptor (OXTR) gene, and amygdalar and hippocampal volumes, two brain regions implicated in emotional processing.Methods: We recruited 63 Caucasian South African adults (35 women) with and without social anxiety disorder. Childhood EN was assessed using the Childhood Trauma Questionnaire. rs53576 and rs2254298 genotypes, as well as methylation status, was determined using DNA purified from whole blood. Bilateral amygdalar and hippocampal volumes were determined by structural magnetic resonance imaging. The relationships between these variables were investigated using linear regression.Results: The interaction of the rs2254298 A risk allele and EN was nominally associated with reduced left hippocampal volume. The rs2254298 A risk allele was independently associated with reduced bilateral amygdalar volumes. We found no association between EN, OXTR methylation and amygdalar or hippocampal volumes. The rs53576 GG risk genotype was, however, associated with decreased OXTR methylation.Conclusions: The rs2254298 A allele may increase susceptibility to the structural brain effects of EN." @default.
- W2915958320 created "2019-03-02" @default.
- W2915958320 creator A5000655439 @default.
- W2915958320 creator A5002528924 @default.
- W2915958320 creator A5004280785 @default.
- W2915958320 creator A5006614121 @default.
- W2915958320 creator A5009033059 @default.
- W2915958320 creator A5036665856 @default.
- W2915958320 creator A5049130017 @default.
- W2915958320 creator A5055184922 @default.
- W2915958320 date "2019-04-02" @default.
- W2915958320 modified "2023-10-14" @default.
- W2915958320 title "Childhood emotional neglect and oxytocin receptor variants: Association with limbic brain volumes" @default.
- W2915958320 cites W1067107096 @default.
- W2915958320 cites W1118719152 @default.
- W2915958320 cites W1164968108 @default.
- W2915958320 cites W1587993760 @default.
- W2915958320 cites W1757360216 @default.
- W2915958320 cites W1848009667 @default.
- W2915958320 cites W1890675559 @default.
- W2915958320 cites W1943473395 @default.
- W2915958320 cites W1964670163 @default.
- W2915958320 cites W1965672724 @default.
- W2915958320 cites W1970043959 @default.
- W2915958320 cites W1972100326 @default.
- W2915958320 cites W1973208215 @default.
- W2915958320 cites W1974011030 @default.
- W2915958320 cites W1974382475 @default.
- W2915958320 cites W1982341034 @default.
- W2915958320 cites W1983037600 @default.
- W2915958320 cites W1983954953 @default.
- W2915958320 cites W1993988720 @default.
- W2915958320 cites W1996191280 @default.
- W2915958320 cites W1997029803 @default.
- W2915958320 cites W1997982013 @default.
- W2915958320 cites W1998424332 @default.
- W2915958320 cites W1998528732 @default.
- W2915958320 cites W1999113518 @default.
- W2915958320 cites W1999436824 @default.
- W2915958320 cites W2001484008 @default.
- W2915958320 cites W2004293194 @default.
- W2915958320 cites W2006551290 @default.
- W2915958320 cites W2009242258 @default.
- W2915958320 cites W2011001109 @default.
- W2915958320 cites W2011027277 @default.
- W2915958320 cites W2011988545 @default.
- W2915958320 cites W2012006909 @default.
- W2915958320 cites W2017720947 @default.
- W2915958320 cites W2020897240 @default.
- W2915958320 cites W2021501413 @default.
- W2915958320 cites W2023595618 @default.
- W2915958320 cites W2027032265 @default.
- W2915958320 cites W2031425398 @default.
- W2915958320 cites W2032525748 @default.
- W2915958320 cites W2032748584 @default.
- W2915958320 cites W2040710885 @default.
- W2915958320 cites W2042402104 @default.
- W2915958320 cites W2046962754 @default.
- W2915958320 cites W2048952046 @default.
- W2915958320 cites W2051405502 @default.
- W2915958320 cites W2056105279 @default.
- W2915958320 cites W2061740920 @default.
- W2915958320 cites W2070684401 @default.
- W2915958320 cites W2071664808 @default.
- W2915958320 cites W2072061544 @default.
- W2915958320 cites W2074783654 @default.
- W2915958320 cites W2079348783 @default.
- W2915958320 cites W2089304376 @default.
- W2915958320 cites W2090409302 @default.
- W2915958320 cites W2100178612 @default.
- W2915958320 cites W2103481737 @default.
- W2915958320 cites W2104323563 @default.
- W2915958320 cites W2106930497 @default.
- W2915958320 cites W2108672095 @default.
- W2915958320 cites W2110208125 @default.
- W2915958320 cites W2114970231 @default.
- W2915958320 cites W2121369614 @default.
- W2915958320 cites W2123137331 @default.
- W2915958320 cites W2128108847 @default.
- W2915958320 cites W2128152843 @default.
- W2915958320 cites W2128740541 @default.
- W2915958320 cites W2132152083 @default.
- W2915958320 cites W2134862200 @default.
- W2915958320 cites W2135606779 @default.
- W2915958320 cites W2138559331 @default.
- W2915958320 cites W2140989038 @default.
- W2915958320 cites W2143428277 @default.
- W2915958320 cites W2144811422 @default.
- W2915958320 cites W2151721316 @default.
- W2915958320 cites W2152293970 @default.
- W2915958320 cites W2152656267 @default.
- W2915958320 cites W2156891942 @default.
- W2915958320 cites W2157270343 @default.
- W2915958320 cites W2157848968 @default.
- W2915958320 cites W2158679186 @default.
- W2915958320 cites W2163675850 @default.
- W2915958320 cites W2169807760 @default.
- W2915958320 cites W2216711948 @default.