Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916004231> ?p ?o ?g. }
- W2916004231 endingPage "1462" @default.
- W2916004231 startingPage "1449" @default.
- W2916004231 abstract "Summary Bacterial toxin–antitoxin systems are important factors implicated in growth inhibition and plasmid maintenance. Type II toxin–antitoxin pairs are regulated at the transcriptional level by the antitoxin itself. Here, we examined how the HigA antitoxin regulates the expression of the Proteus vulgaris higBA toxin–antitoxin operon from the Rts1 plasmid. The HigBA complex adopts a unique architecture suggesting differences in its regulation as compared to classical type II toxin–antitoxin systems. We find that the C‐terminus of the HigA antitoxin is required for dimerization and transcriptional repression. Further, the HigA structure reveals that the C terminus is ordered and does not transition between disorder‐to‐order states upon toxin binding. HigA residue Arg40 recognizes a TpG dinucleotide in hig O2, an evolutionary conserved mode of recognition among prokaryotic and eukaryotic transcription factors. Comparison of the HigBA and HigA‐ hig O2 structures reveals the distance between helix‐turn‐helix motifs of each HigA monomer increases by ~4 Å in order to bind to hig O2. Consistent with these data, HigBA binding to each operator is twofold less tight than HigA alone. Together, these data show the HigB toxin does not act as a co‐repressor suggesting potential novel regulation in this toxin–antitoxin system." @default.
- W2916004231 created "2019-03-02" @default.
- W2916004231 creator A5001255024 @default.
- W2916004231 creator A5032765426 @default.
- W2916004231 creator A5034397418 @default.
- W2916004231 creator A5044537321 @default.
- W2916004231 creator A5045995258 @default.
- W2916004231 creator A5053387578 @default.
- W2916004231 creator A5083358386 @default.
- W2916004231 creator A5085362411 @default.
- W2916004231 date "2019-04-01" @default.
- W2916004231 modified "2023-10-12" @default.
- W2916004231 title "Structural basis of transcriptional regulation by the HigA antitoxin" @default.
- W2916004231 cites W1565197201 @default.
- W2916004231 cites W1604915411 @default.
- W2916004231 cites W1666867306 @default.
- W2916004231 cites W1820567505 @default.
- W2916004231 cites W1914760274 @default.
- W2916004231 cites W1963544294 @default.
- W2916004231 cites W1963873781 @default.
- W2916004231 cites W1964951600 @default.
- W2916004231 cites W1975317507 @default.
- W2916004231 cites W1984816061 @default.
- W2916004231 cites W1989741928 @default.
- W2916004231 cites W1989869773 @default.
- W2916004231 cites W1996140776 @default.
- W2916004231 cites W2012016148 @default.
- W2916004231 cites W2015318086 @default.
- W2916004231 cites W2021197152 @default.
- W2916004231 cites W2030517878 @default.
- W2916004231 cites W2031838815 @default.
- W2916004231 cites W2040508566 @default.
- W2916004231 cites W2053838196 @default.
- W2916004231 cites W2057508736 @default.
- W2916004231 cites W2057808051 @default.
- W2916004231 cites W2061659241 @default.
- W2916004231 cites W2066845647 @default.
- W2916004231 cites W2070252217 @default.
- W2916004231 cites W2070663321 @default.
- W2916004231 cites W2090196960 @default.
- W2916004231 cites W2096792353 @default.
- W2916004231 cites W2099545797 @default.
- W2916004231 cites W2100564823 @default.
- W2916004231 cites W2101002332 @default.
- W2916004231 cites W2102169469 @default.
- W2916004231 cites W2105993993 @default.
- W2916004231 cites W2108142974 @default.
- W2916004231 cites W2112151977 @default.
- W2916004231 cites W2114150529 @default.
- W2916004231 cites W2121315499 @default.
- W2916004231 cites W2124026197 @default.
- W2916004231 cites W2157378009 @default.
- W2916004231 cites W2160084442 @default.
- W2916004231 cites W2170533290 @default.
- W2916004231 cites W2170702959 @default.
- W2916004231 cites W2170964260 @default.
- W2916004231 cites W2180229411 @default.
- W2916004231 cites W2298249827 @default.
- W2916004231 cites W2328055929 @default.
- W2916004231 cites W2420508181 @default.
- W2916004231 cites W2464132585 @default.
- W2916004231 cites W2500395608 @default.
- W2916004231 cites W2592958345 @default.
- W2916004231 cites W2600605767 @default.
- W2916004231 cites W4248872320 @default.
- W2916004231 doi "https://doi.org/10.1111/mmi.14229" @default.
- W2916004231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6561789" @default.
- W2916004231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30793388" @default.
- W2916004231 hasPublicationYear "2019" @default.
- W2916004231 type Work @default.
- W2916004231 sameAs 2916004231 @default.
- W2916004231 citedByCount "15" @default.
- W2916004231 countsByYear W29160042312020 @default.
- W2916004231 countsByYear W29160042312021 @default.
- W2916004231 countsByYear W29160042312022 @default.
- W2916004231 countsByYear W29160042312023 @default.
- W2916004231 crossrefType "journal-article" @default.
- W2916004231 hasAuthorship W2916004231A5001255024 @default.
- W2916004231 hasAuthorship W2916004231A5032765426 @default.
- W2916004231 hasAuthorship W2916004231A5034397418 @default.
- W2916004231 hasAuthorship W2916004231A5044537321 @default.
- W2916004231 hasAuthorship W2916004231A5045995258 @default.
- W2916004231 hasAuthorship W2916004231A5053387578 @default.
- W2916004231 hasAuthorship W2916004231A5083358386 @default.
- W2916004231 hasAuthorship W2916004231A5085362411 @default.
- W2916004231 hasBestOaLocation W29160042311 @default.
- W2916004231 hasConcept C104317684 @default.
- W2916004231 hasConcept C138885662 @default.
- W2916004231 hasConcept C150194340 @default.
- W2916004231 hasConcept C158448853 @default.
- W2916004231 hasConcept C179926584 @default.
- W2916004231 hasConcept C186310378 @default.
- W2916004231 hasConcept C203075996 @default.
- W2916004231 hasConcept C22744801 @default.
- W2916004231 hasConcept C27153228 @default.
- W2916004231 hasConcept C2777367657 @default.
- W2916004231 hasConcept C2778973234 @default.
- W2916004231 hasConcept C41895202 @default.