FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916064082> ?p ?o ?g. }

• W2916064082 endingPage "25" @default.
• W2916064082 startingPage "17" @default.
• W2916064082 abstract "The immense potential of transaminase-catalyzed reactions for chiral amine synthesis is often hampered by unfavorable thermodynamic equilibrium positions and product inhibition issues. In the here presented proof of concept, we demonstrate a membrane assisted strategy for addressing these challenges. It involves a separation based on differently sized amine donor and amine product molecules. Novel High Molecular Weight (HMW) amine donors, provided in excess for thermodynamic equilibrium shifting, are successfully employed in transaminase-catalyzed reactions and are effectively retained by commercial nanofiltration membranes by a size exclusion mechanism. Retention of HMW amine donors combined with selective product removal, in batch mode, shifted the equilibrium enhancing substrate conversion by an additional 25% compared to the control reaction. Along with the potential of this approach, certain limitations were also revealed in this study. Only few of the investigated enzymes accepted the HMW donor molecules, and along with very efficient amine product removal, there was undesirable loss of ketone substrate. Therefore, a broader enzyme screening, and the selection of a selective and solvent stable membrane, is essential for better and broader applicability of the concept." @default.
• W2916064082 created "2019-03-02" @default.
• W2916064082 creator A5004420169 @default.
• W2916064082 creator A5009820054 @default.
• W2916064082 creator A5031181844 @default.
• W2916064082 creator A5062300140 @default.
• W2916064082 creator A5084583227 @default.
• W2916064082 date "2019-05-01" @default.
• W2916064082 modified "2023-10-14" @default.
• W2916064082 title "Application of novel High Molecular Weight amine donors in chiral amine synthesis facilitates integrated downstream processing and provides in situ product recovery opportunities" @default.
• W2916064082 cites W1847874701 @default.
• W2916064082 cites W1937735508 @default.
• W2916064082 cites W1965314862 @default.
• W2916064082 cites W1971568096 @default.
• W2916064082 cites W1986056153 @default.
• W2916064082 cites W1988882990 @default.
• W2916064082 cites W2010370307 @default.
• W2916064082 cites W2013652826 @default.
• W2916064082 cites W2024851405 @default.
• W2916064082 cites W2046194021 @default.
• W2916064082 cites W2078689672 @default.
• W2916064082 cites W2092140785 @default.
• W2916064082 cites W2108742112 @default.
• W2916064082 cites W2124493778 @default.
• W2916064082 cites W2135551767 @default.
• W2916064082 cites W2153433577 @default.
• W2916064082 cites W2195655442 @default.
• W2916064082 cites W2299246692 @default.
• W2916064082 cites W2328445540 @default.
• W2916064082 cites W2471047961 @default.
• W2916064082 cites W2496645452 @default.
• W2916064082 cites W2510987394 @default.
• W2916064082 cites W2524638452 @default.
• W2916064082 cites W2528127298 @default.
• W2916064082 cites W2529712864 @default.
• W2916064082 cites W2552517787 @default.
• W2916064082 cites W2581982767 @default.
• W2916064082 cites W2600356273 @default.
• W2916064082 cites W2610736062 @default.
• W2916064082 cites W2613234968 @default.
• W2916064082 cites W2771222607 @default.
• W2916064082 cites W2783968834 @default.
• W2916064082 cites W2809826342 @default.
• W2916064082 cites W2900494791 @default.
• W2916064082 doi "https://doi.org/10.1016/j.procbio.2019.02.018" @default.
• W2916064082 hasPublicationYear "2019" @default.
• W2916064082 type Work @default.
• W2916064082 sameAs 2916064082 @default.
• W2916064082 citedByCount "6" @default.
• W2916064082 countsByYear W29160640822019 @default.
• W2916064082 countsByYear W29160640822020 @default.
• W2916064082 countsByYear W29160640822021 @default.
• W2916064082 countsByYear W29160640822022 @default.
• W2916064082 countsByYear W29160640822023 @default.
• W2916064082 crossrefType "journal-article" @default.
• W2916064082 hasAuthorship W2916064082A5004420169 @default.
• W2916064082 hasAuthorship W2916064082A5009820054 @default.
• W2916064082 hasAuthorship W2916064082A5031181844 @default.
• W2916064082 hasAuthorship W2916064082A5062300140 @default.
• W2916064082 hasAuthorship W2916064082A5084583227 @default.
• W2916064082 hasConcept C111368507 @default.
• W2916064082 hasConcept C127313418 @default.
• W2916064082 hasConcept C131779359 @default.
• W2916064082 hasConcept C150757390 @default.
• W2916064082 hasConcept C161790260 @default.
• W2916064082 hasConcept C178790620 @default.
• W2916064082 hasConcept C181199279 @default.
• W2916064082 hasConcept C185592680 @default.
• W2916064082 hasConcept C21951064 @default.
• W2916064082 hasConcept C2776877979 @default.
• W2916064082 hasConcept C2777289219 @default.
• W2916064082 hasConcept C2780434155 @default.
• W2916064082 hasConcept C41625074 @default.
• W2916064082 hasConcept C43617362 @default.
• W2916064082 hasConcept C55493867 @default.
• W2916064082 hasConcept C67568554 @default.
• W2916064082 hasConceptScore W2916064082C111368507 @default.
• W2916064082 hasConceptScore W2916064082C127313418 @default.
• W2916064082 hasConceptScore W2916064082C131779359 @default.
• W2916064082 hasConceptScore W2916064082C150757390 @default.
• W2916064082 hasConceptScore W2916064082C161790260 @default.
• W2916064082 hasConceptScore W2916064082C178790620 @default.
• W2916064082 hasConceptScore W2916064082C181199279 @default.
• W2916064082 hasConceptScore W2916064082C185592680 @default.
• W2916064082 hasConceptScore W2916064082C21951064 @default.
• W2916064082 hasConceptScore W2916064082C2776877979 @default.
• W2916064082 hasConceptScore W2916064082C2777289219 @default.
• W2916064082 hasConceptScore W2916064082C2780434155 @default.
• W2916064082 hasConceptScore W2916064082C41625074 @default.
• W2916064082 hasConceptScore W2916064082C43617362 @default.
• W2916064082 hasConceptScore W2916064082C55493867 @default.
• W2916064082 hasConceptScore W2916064082C67568554 @default.
• W2916064082 hasLocation W29160640821 @default.
• W2916064082 hasOpenAccess W2916064082 @default.
• W2916064082 hasPrimaryLocation W29160640821 @default.
• W2916064082 hasRelatedWork W1845624145 @default.
• W2916064082 hasRelatedWork W1899083885 @default.
• W2916064082 hasRelatedWork W1987755785 @default.

• next