Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916077215> ?p ?o ?g. }
- W2916077215 abstract "Abstract Insulin resistance (IR) is a hallmark of type 2 diabetes, metabolic syndrome and cardiometabolic risk. An epigenetic phenomena such as DNA methylation might be involved in the onset and development of systemic IR. The aim of this study was to explore the genetic DNA methylation levels in peripheral white blood cells with the objective of identifying epigenetic signatures associated with IR measured by the Homeostatic Model Assessment of IR (HOMA-IR) following an epigenome-wide association study approach. DNA methylation levels were assessed using Infinium Methylation Assay (Illumina), and were associated with HOMA-IR values of participants from the Methyl Epigenome Network Association (MENA) project, finding statistical associations for at least 798 CpGs. A stringent statistical analysis revealed that 478 of them showed a differential methylation pattern between individuals with HOMA-IR ≤ 3 and > 3. ROC curves of top four CpGs out of 478 allowed differentiating individuals between both groups (AUC≈0.88). This study demonstrated the association between DNA methylation in some specific CpGs and HOMA-IR values that will help to the understanding and in the development of new strategies for personalized approaches to predict and prevent IR-associated diseases." @default.
- W2916077215 created "2019-03-02" @default.
- W2916077215 creator A5016946894 @default.
- W2916077215 creator A5035865099 @default.
- W2916077215 creator A5038267333 @default.
- W2916077215 creator A5048675989 @default.
- W2916077215 creator A5060013848 @default.
- W2916077215 creator A5067889396 @default.
- W2916077215 creator A5068217114 @default.
- W2916077215 date "2019-02-21" @default.
- W2916077215 modified "2023-10-13" @default.
- W2916077215 title "Epigenome-wide association study in peripheral white blood cells involving insulin resistance" @default.
- W2916077215 cites W1808248494 @default.
- W2916077215 cites W1910353033 @default.
- W2916077215 cites W1923460211 @default.
- W2916077215 cites W1925664165 @default.
- W2916077215 cites W1942877788 @default.
- W2916077215 cites W1967041777 @default.
- W2916077215 cites W1968335881 @default.
- W2916077215 cites W1974314280 @default.
- W2916077215 cites W1982181567 @default.
- W2916077215 cites W2014597082 @default.
- W2916077215 cites W2018218953 @default.
- W2916077215 cites W2019559882 @default.
- W2916077215 cites W2020541351 @default.
- W2916077215 cites W2021459974 @default.
- W2916077215 cites W2024042905 @default.
- W2916077215 cites W2035284391 @default.
- W2916077215 cites W2046058416 @default.
- W2916077215 cites W2047160399 @default.
- W2916077215 cites W2048868675 @default.
- W2916077215 cites W2050286601 @default.
- W2916077215 cites W2052027792 @default.
- W2916077215 cites W2053308873 @default.
- W2916077215 cites W2067498398 @default.
- W2916077215 cites W2089473585 @default.
- W2916077215 cites W2102807338 @default.
- W2916077215 cites W2106608030 @default.
- W2916077215 cites W2107665951 @default.
- W2916077215 cites W2109654396 @default.
- W2916077215 cites W2115709314 @default.
- W2916077215 cites W2116790770 @default.
- W2916077215 cites W2124572258 @default.
- W2916077215 cites W2128130893 @default.
- W2916077215 cites W2133112923 @default.
- W2916077215 cites W2136895197 @default.
- W2916077215 cites W2137147070 @default.
- W2916077215 cites W2139316343 @default.
- W2916077215 cites W2145708730 @default.
- W2916077215 cites W2146107508 @default.
- W2916077215 cites W2147617736 @default.
- W2916077215 cites W2152228240 @default.
- W2916077215 cites W2152927657 @default.
- W2916077215 cites W2160234571 @default.
- W2916077215 cites W2161922342 @default.
- W2916077215 cites W2163589042 @default.
- W2916077215 cites W2165387982 @default.
- W2916077215 cites W2166000498 @default.
- W2916077215 cites W2167080331 @default.
- W2916077215 cites W2169556367 @default.
- W2916077215 cites W2257819899 @default.
- W2916077215 cites W2265429569 @default.
- W2916077215 cites W2266765416 @default.
- W2916077215 cites W2279723444 @default.
- W2916077215 cites W2286048432 @default.
- W2916077215 cites W2294635187 @default.
- W2916077215 cites W2298284297 @default.
- W2916077215 cites W2316239158 @default.
- W2916077215 cites W2332043828 @default.
- W2916077215 cites W2341587185 @default.
- W2916077215 cites W2342520699 @default.
- W2916077215 cites W2346513496 @default.
- W2916077215 cites W2361562022 @default.
- W2916077215 cites W2408117442 @default.
- W2916077215 cites W2417808663 @default.
- W2916077215 cites W2423194785 @default.
- W2916077215 cites W2443002311 @default.
- W2916077215 cites W2483013668 @default.
- W2916077215 cites W2514674853 @default.
- W2916077215 cites W2516029638 @default.
- W2916077215 cites W2538941917 @default.
- W2916077215 cites W2561301122 @default.
- W2916077215 cites W2568185790 @default.
- W2916077215 cites W2576832795 @default.
- W2916077215 cites W2587344758 @default.
- W2916077215 cites W2592437555 @default.
- W2916077215 cites W2593895822 @default.
- W2916077215 cites W2607031541 @default.
- W2916077215 cites W2619550260 @default.
- W2916077215 cites W2750777289 @default.
- W2916077215 cites W2757030954 @default.
- W2916077215 cites W2761025121 @default.
- W2916077215 cites W2766001749 @default.
- W2916077215 cites W2766515632 @default.
- W2916077215 cites W2769479878 @default.
- W2916077215 cites W2772478866 @default.
- W2916077215 cites W2773440277 @default.
- W2916077215 cites W2777970856 @default.
- W2916077215 cites W2783270596 @default.
- W2916077215 cites W2787288493 @default.