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• W2916082620 abstract "The highly polymorphic genes of the major histocompatibility complex (MHC) class I are involved in defense against viruses and other intracellular pathogens. Although several studies found reduced MHC class I diversity in bonobos in comparison to the closely related chimpanzee, it is unclear if this lower diversity also influences the functional ability of MHC class I molecules in bonobos. Here, we use a bioinformatic approach to analyze the viral peptide binding ability of all published bonobo MHC class I molecules (n = 58) in comparison to all published chimpanzee MHC class I molecules (n = 161) for the class I loci A, B, C and A-like.We examined the peptide binding ability of all 219 different MHC class I molecules to 5,788,712 peptides derived from 1432 different primate viruses and analyzed the percentage of bound peptides and the overlap of the peptide binding repertoires of the two species. We conducted multiple levels of analysis on the species-, population- and individual-level to account for the characterization of MHC variation in a larger number of chimpanzees and their broader geographic distribution. We found a lower percentage of bound peptides in bonobos at the B locus in the population-level comparison and at the B and C loci in the individual-level comparison. Furthermore, we found evidence of a limited peptide binding repertoire in bonobos by tree-based visualization of functional clustering of MHC molecules, as well as an analysis of peptides bound by both species.Our results suggest a reduced MHC class I viral peptide binding ability at the B and C loci in bonobos compared to chimpanzees. The effects of this finding on the immune defense against viruses in wild living bonobos are unclear. However, special caution is needed to prevent introduction and spread of new viruses to bonobos, as their defensive ability to cope with new viruses could be limited compared to chimpanzees." @default.
• W2916082620 created "2019-03-02" @default.
• W2916082620 creator A5083668453 @default.
• W2916082620 creator A5090931551 @default.
• W2916082620 date "2019-01-10" @default.
• W2916082620 modified "2023-10-06" @default.
• W2916082620 title "Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees" @default.
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• W2916082620 doi "https://doi.org/10.1186/s12862-019-1352-0" @default.
• W2916082620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6327438" @default.
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• W2916082620 hasPublicationYear "2019" @default.
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