Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916125453> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2916125453 endingPage "102" @default.
- W2916125453 startingPage "95" @default.
- W2916125453 abstract "Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death are potential endpoints. Whether BCS is useful in monitoring animals with bleomycin-induced lung injury has not been reported. Body weight (BW) is a common humane endpoint for this model, but because the lungs increase in weight as BW decreases, the animal's true physical condition could be masked when using BW as the sole endpoint criterion. Therefore, our goal here was to assess the usefulness of BCS in monitoring health status in a mouse model of lung injury. Lung injury was caused by acute instil- lation of the fibrogenic antibiotic bleomycin into the lungs through the trachea. Male C57BL/6 mice received bleomycin (0.075 U) dissolved in saline or saline alone. Bleomycin instillation led to a doubling of lung weight and decreases in both BW and BCS, compared with saline instillation. The changes in BW and BCS were significantly correlated with lung weight. When the adjusted BW was used (corrected for the increase in lung weight), the correlation was unchanged, suggesting that the increase in lung weight did not significantly mask the decrease in BW. Bleomycin instillation caused decreases in both soleus and visceral epididymal fat masses. The change in BCS was significantly correlated with both soleus and VEF mass, suggesting that BCS is reflective of the systemic loss of muscle and fat mass. Our findings suggest that BW and BCS are significantly correlated to lung injury in the bleomycin model of lung fibrosis and that BCS is an appropriate alternative humane endpoint in this mouse model." @default.
- W2916125453 created "2019-03-02" @default.
- W2916125453 creator A5010814330 @default.
- W2916125453 creator A5029805752 @default.
- W2916125453 creator A5044655869 @default.
- W2916125453 date "2019-04-01" @default.
- W2916125453 modified "2023-09-23" @default.
- W2916125453 title "Monitoring the Health Status of Mice with Bleomycin-induced Lung Injury by Using Body Condition Scoring" @default.
- W2916125453 cites W1513756754 @default.
- W2916125453 cites W1852619401 @default.
- W2916125453 cites W191426077 @default.
- W2916125453 cites W1966905570 @default.
- W2916125453 cites W2003578457 @default.
- W2916125453 cites W2038935575 @default.
- W2916125453 cites W2041588050 @default.
- W2916125453 cites W2046501504 @default.
- W2916125453 cites W2053102492 @default.
- W2916125453 cites W2062205755 @default.
- W2916125453 cites W2065977597 @default.
- W2916125453 cites W2103154415 @default.
- W2916125453 cites W2140923971 @default.
- W2916125453 cites W2155353950 @default.
- W2916125453 cites W2167211373 @default.
- W2916125453 cites W2171355576 @default.
- W2916125453 cites W2182182388 @default.
- W2916125453 cites W2413417451 @default.
- W2916125453 cites W2571646230 @default.
- W2916125453 cites W2610199736 @default.
- W2916125453 doi "https://doi.org/10.30802/aalas-cm-18-000060" @default.
- W2916125453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6464078" @default.
- W2916125453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30808435" @default.
- W2916125453 hasPublicationYear "2019" @default.
- W2916125453 type Work @default.
- W2916125453 sameAs 2916125453 @default.
- W2916125453 citedByCount "18" @default.
- W2916125453 countsByYear W29161254532019 @default.
- W2916125453 countsByYear W29161254532021 @default.
- W2916125453 countsByYear W29161254532022 @default.
- W2916125453 countsByYear W29161254532023 @default.
- W2916125453 crossrefType "journal-article" @default.
- W2916125453 hasAuthorship W2916125453A5010814330 @default.
- W2916125453 hasAuthorship W2916125453A5029805752 @default.
- W2916125453 hasAuthorship W2916125453A5044655869 @default.
- W2916125453 hasBestOaLocation W29161254532 @default.
- W2916125453 hasConcept C126322002 @default.
- W2916125453 hasConcept C134018914 @default.
- W2916125453 hasConcept C142724271 @default.
- W2916125453 hasConcept C147583825 @default.
- W2916125453 hasConcept C2776232574 @default.
- W2916125453 hasConcept C2776694085 @default.
- W2916125453 hasConcept C2777397205 @default.
- W2916125453 hasConcept C2777714996 @default.
- W2916125453 hasConcept C2779764123 @default.
- W2916125453 hasConcept C42407357 @default.
- W2916125453 hasConcept C71924100 @default.
- W2916125453 hasConcept C90924648 @default.
- W2916125453 hasConceptScore W2916125453C126322002 @default.
- W2916125453 hasConceptScore W2916125453C134018914 @default.
- W2916125453 hasConceptScore W2916125453C142724271 @default.
- W2916125453 hasConceptScore W2916125453C147583825 @default.
- W2916125453 hasConceptScore W2916125453C2776232574 @default.
- W2916125453 hasConceptScore W2916125453C2776694085 @default.
- W2916125453 hasConceptScore W2916125453C2777397205 @default.
- W2916125453 hasConceptScore W2916125453C2777714996 @default.
- W2916125453 hasConceptScore W2916125453C2779764123 @default.
- W2916125453 hasConceptScore W2916125453C42407357 @default.
- W2916125453 hasConceptScore W2916125453C71924100 @default.
- W2916125453 hasConceptScore W2916125453C90924648 @default.
- W2916125453 hasIssue "2" @default.
- W2916125453 hasLocation W29161254531 @default.
- W2916125453 hasLocation W29161254532 @default.
- W2916125453 hasLocation W29161254533 @default.
- W2916125453 hasLocation W29161254534 @default.
- W2916125453 hasOpenAccess W2916125453 @default.
- W2916125453 hasPrimaryLocation W29161254531 @default.
- W2916125453 hasRelatedWork W1983012135 @default.
- W2916125453 hasRelatedWork W2009877402 @default.
- W2916125453 hasRelatedWork W2011598966 @default.
- W2916125453 hasRelatedWork W2014432291 @default.
- W2916125453 hasRelatedWork W2023991882 @default.
- W2916125453 hasRelatedWork W2038591397 @default.
- W2916125453 hasRelatedWork W2054119993 @default.
- W2916125453 hasRelatedWork W2056503472 @default.
- W2916125453 hasRelatedWork W2071934027 @default.
- W2916125453 hasRelatedWork W2341096078 @default.
- W2916125453 hasVolume "69" @default.
- W2916125453 isParatext "false" @default.
- W2916125453 isRetracted "false" @default.
- W2916125453 magId "2916125453" @default.
- W2916125453 workType "article" @default.