Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916155839> ?p ?o ?g. }
- W2916155839 abstract "A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine." @default.
- W2916155839 created "2019-03-02" @default.
- W2916155839 creator A5010996325 @default.
- W2916155839 creator A5021873166 @default.
- W2916155839 creator A5033570111 @default.
- W2916155839 creator A5051005829 @default.
- W2916155839 creator A5055276058 @default.
- W2916155839 creator A5061682089 @default.
- W2916155839 creator A5063288234 @default.
- W2916155839 creator A5064655594 @default.
- W2916155839 creator A5081140044 @default.
- W2916155839 creator A5083654890 @default.
- W2916155839 date "2019-02-19" @default.
- W2916155839 modified "2023-10-12" @default.
- W2916155839 title "Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages" @default.
- W2916155839 cites W121947928 @default.
- W2916155839 cites W1570357111 @default.
- W2916155839 cites W1595293335 @default.
- W2916155839 cites W1900765734 @default.
- W2916155839 cites W1902150932 @default.
- W2916155839 cites W1909714874 @default.
- W2916155839 cites W1923042616 @default.
- W2916155839 cites W1976582565 @default.
- W2916155839 cites W1977205972 @default.
- W2916155839 cites W1981500982 @default.
- W2916155839 cites W1983972858 @default.
- W2916155839 cites W1987200107 @default.
- W2916155839 cites W1997774819 @default.
- W2916155839 cites W2001339909 @default.
- W2916155839 cites W2012490955 @default.
- W2916155839 cites W2013503010 @default.
- W2916155839 cites W2014775641 @default.
- W2916155839 cites W2016654049 @default.
- W2916155839 cites W2018415534 @default.
- W2916155839 cites W2024411193 @default.
- W2916155839 cites W2029155338 @default.
- W2916155839 cites W2047392191 @default.
- W2916155839 cites W2047499046 @default.
- W2916155839 cites W2052554412 @default.
- W2916155839 cites W2052910931 @default.
- W2916155839 cites W2054540776 @default.
- W2916155839 cites W2057809738 @default.
- W2916155839 cites W2059164493 @default.
- W2916155839 cites W2060628162 @default.
- W2916155839 cites W2066164950 @default.
- W2916155839 cites W2067401763 @default.
- W2916155839 cites W2068104262 @default.
- W2916155839 cites W2068234766 @default.
- W2916155839 cites W2075832262 @default.
- W2916155839 cites W2077553363 @default.
- W2916155839 cites W2087863438 @default.
- W2916155839 cites W2096106665 @default.
- W2916155839 cites W2096728803 @default.
- W2916155839 cites W2100874193 @default.
- W2916155839 cites W2102025568 @default.
- W2916155839 cites W2104397453 @default.
- W2916155839 cites W2104890139 @default.
- W2916155839 cites W2109491705 @default.
- W2916155839 cites W2109843135 @default.
- W2916155839 cites W2117767336 @default.
- W2916155839 cites W2118603398 @default.
- W2916155839 cites W2120970035 @default.
- W2916155839 cites W2126263193 @default.
- W2916155839 cites W2130255439 @default.
- W2916155839 cites W2138019675 @default.
- W2916155839 cites W2146152985 @default.
- W2916155839 cites W2151311370 @default.
- W2916155839 cites W2157780537 @default.
- W2916155839 cites W2157933861 @default.
- W2916155839 cites W2158659385 @default.
- W2916155839 cites W2161788109 @default.
- W2916155839 cites W2167837285 @default.
- W2916155839 cites W2169619812 @default.
- W2916155839 cites W2181471414 @default.
- W2916155839 cites W2201019342 @default.
- W2916155839 cites W2273982344 @default.
- W2916155839 cites W2306738086 @default.
- W2916155839 cites W2356452812 @default.
- W2916155839 cites W2467871258 @default.
- W2916155839 cites W2487513114 @default.
- W2916155839 cites W2509552885 @default.
- W2916155839 cites W2515667551 @default.
- W2916155839 cites W2597709926 @default.
- W2916155839 cites W2618307797 @default.
- W2916155839 cites W2654510028 @default.
- W2916155839 cites W2732637235 @default.
- W2916155839 cites W2747503939 @default.
- W2916155839 cites W2772071913 @default.
- W2916155839 doi "https://doi.org/10.15252/embr.201846927" @default.
- W2916155839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6446200" @default.
- W2916155839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30783017" @default.
- W2916155839 hasPublicationYear "2019" @default.
- W2916155839 type Work @default.
- W2916155839 sameAs 2916155839 @default.
- W2916155839 citedByCount "81" @default.
- W2916155839 countsByYear W29161558392019 @default.
- W2916155839 countsByYear W29161558392020 @default.
- W2916155839 countsByYear W29161558392021 @default.
- W2916155839 countsByYear W29161558392022 @default.
- W2916155839 countsByYear W29161558392023 @default.