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• W2916183574 abstract "Waldenström macroglobulinemia (WM) is a rare lymphoproliferative disorder. Up to now, therapeutic choice was not influenced by the biological characteristics of the disease. Here, we will review how recent advances in biology in WM may affect therapy strategy. Recently, WM has been described as a new oncogenic model. MyD88 mutation has been described as a key driver mutation and has functional consequences which could be targeted. Other mutations, such as CXCR4 or TP53, have been reported. These mutations are associated with different clinical presentation, prognosis, and treatment response. Mutational status may influence therapeutic choice in some patients but additional data are required. New targeted therapies are on development." @default.
• W2916183574 created "2019-03-02" @default.
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• W2916183574 date "2019-02-26" @default.
• W2916183574 modified "2023-10-02" @default.
• W2916183574 title "How Recent Advances in Biology of Waldenström’s Macroglobulinemia May Affect Therapy Strategy" @default.
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• W2916183574 doi "https://doi.org/10.1007/s11912-019-0768-4" @default.
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• W2916183574 hasPublicationYear "2019" @default.
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