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- W2916193724 abstract "The adaptive immune system uses several strategies to generate a repertoire of T cell receptors (TCR) with sufficient diversity to recognize the universe of potential pathogens. However, it remains unclear how differences in the T cell receptor (TCR) contribute to heterogeneity in T cell state. In this study, we used polychromatic flow cytometry to isolate highly pure CD4+/CD8+ naive and memory T cells, and applied deep sequencing to characterize corresponding TCR β-chain (TCRβ) complementary-determining region 3 (CDR3) repertoires. We find that shorter TCRβ CDR3s with fewer insertions were highly enriched during thymic selection. Antigen-experienced T cells (memory T cells) harbour shorter CDR3s versus naive T cells. Moreover, the public TCRβ CDR3 clonotypes within cell subsets or interindividual tend to have shorter CDR3 length and a significantly larger size compared with “private” clonotypes. Taken together, shorter CDR3s highly enriched during thymic selection and antigen-driven selection, and further enriched in public T-cell responses. These results indicated that it may be evolutionary pressures drive short CDR3s to recognize most of antigen in nature." @default.
- W2916193724 created "2019-03-02" @default.
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- W2916193724 date "2019-02-26" @default.
- W2916193724 modified "2023-10-02" @default.
- W2916193724 title "Shorter TCR β-Chains Are Highly Enriched During Thymic Selection and Antigen-Driven Selection" @default.
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- W2916193724 doi "https://doi.org/10.3389/fimmu.2019.00299" @default.
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