Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916213106> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2916213106 endingPage "1018" @default.
- W2916213106 startingPage "1007" @default.
- W2916213106 abstract "The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis specifically in cancer cells with little effect on normal cells. We have previously shown that TRAIL signaling is altered in most ovarian cancer patients and that resistance to TRAIL contributes to ovarian cancer progression. In this study, we investigated whether resistance to TRAIL may be overcome by a monoclonal TRAILR2 (DR5) agonistic antibody (AD5-10). We found that the joint presence of AD5-10 with TRAIL and natural killer (NK) cells expressing TRAIL resensitizes ovarian cancer cells to apoptosis in vitro and in vivo, respectively. The combination of AD5-10 with carboplatin exerts a more than additive effect in vitro, which may at least partially be explained by the fact that carboplatin triggers DR5 expression on ovarian cancer cells. Moreover, AD5-10 restores the sensitivity of platin-resistant ovarian cancer to carboplatin in vivo. In addition, we found that TRAIL expression and NK cells are abundant in the tumor microenvironment and that depletion of NK cells abolishes the antitumor activity of AD5-10. This indicates that NK-mediated immunosurveillance against ovarian cancer might be mediated by TRAIL and that apoptosis induced by AD5-10 requires the presence of NK cells. In conclusion, this study indicates a key role and strong antitumorigenic effect of DR5 and highlights a novel link between NK-mediated immunosurveillance and activation of DR5-mediated apoptosis in ovarian cancer. Mol Cancer Ther; 9(4); 1007-18. (c)2010 AACR." @default.
- W2916213106 created "2019-03-02" @default.
- W2916213106 creator A5004175706 @default.
- W2916213106 creator A5013926040 @default.
- W2916213106 creator A5019700420 @default.
- W2916213106 creator A5023641042 @default.
- W2916213106 creator A5024574476 @default.
- W2916213106 creator A5048289868 @default.
- W2916213106 creator A5066055526 @default.
- W2916213106 creator A5074302258 @default.
- W2916213106 creator A5079620940 @default.
- W2916213106 creator A5082175264 @default.
- W2916213106 creator A5083486926 @default.
- W2916213106 creator A5084623534 @default.
- W2916213106 date "2010-01-01" @default.
- W2916213106 modified "2023-09-23" @default.
- W2916213106 title "Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer" @default.
- W2916213106 hasPublicationYear "2010" @default.
- W2916213106 type Work @default.
- W2916213106 sameAs 2916213106 @default.
- W2916213106 citedByCount "0" @default.
- W2916213106 crossrefType "journal-article" @default.
- W2916213106 hasAuthorship W2916213106A5004175706 @default.
- W2916213106 hasAuthorship W2916213106A5013926040 @default.
- W2916213106 hasAuthorship W2916213106A5019700420 @default.
- W2916213106 hasAuthorship W2916213106A5023641042 @default.
- W2916213106 hasAuthorship W2916213106A5024574476 @default.
- W2916213106 hasAuthorship W2916213106A5048289868 @default.
- W2916213106 hasAuthorship W2916213106A5066055526 @default.
- W2916213106 hasAuthorship W2916213106A5074302258 @default.
- W2916213106 hasAuthorship W2916213106A5079620940 @default.
- W2916213106 hasAuthorship W2916213106A5082175264 @default.
- W2916213106 hasAuthorship W2916213106A5083486926 @default.
- W2916213106 hasAuthorship W2916213106A5084623534 @default.
- W2916213106 hasConcept C121608353 @default.
- W2916213106 hasConcept C126322002 @default.
- W2916213106 hasConcept C17991360 @default.
- W2916213106 hasConcept C190283241 @default.
- W2916213106 hasConcept C203014093 @default.
- W2916213106 hasConcept C2776694085 @default.
- W2916213106 hasConcept C2776885095 @default.
- W2916213106 hasConcept C2778239845 @default.
- W2916213106 hasConcept C2780427987 @default.
- W2916213106 hasConcept C2781451048 @default.
- W2916213106 hasConcept C502942594 @default.
- W2916213106 hasConcept C55493867 @default.
- W2916213106 hasConcept C71924100 @default.
- W2916213106 hasConcept C86803240 @default.
- W2916213106 hasConcept C8891405 @default.
- W2916213106 hasConcept C96232424 @default.
- W2916213106 hasConceptScore W2916213106C121608353 @default.
- W2916213106 hasConceptScore W2916213106C126322002 @default.
- W2916213106 hasConceptScore W2916213106C17991360 @default.
- W2916213106 hasConceptScore W2916213106C190283241 @default.
- W2916213106 hasConceptScore W2916213106C203014093 @default.
- W2916213106 hasConceptScore W2916213106C2776694085 @default.
- W2916213106 hasConceptScore W2916213106C2776885095 @default.
- W2916213106 hasConceptScore W2916213106C2778239845 @default.
- W2916213106 hasConceptScore W2916213106C2780427987 @default.
- W2916213106 hasConceptScore W2916213106C2781451048 @default.
- W2916213106 hasConceptScore W2916213106C502942594 @default.
- W2916213106 hasConceptScore W2916213106C55493867 @default.
- W2916213106 hasConceptScore W2916213106C71924100 @default.
- W2916213106 hasConceptScore W2916213106C86803240 @default.
- W2916213106 hasConceptScore W2916213106C8891405 @default.
- W2916213106 hasConceptScore W2916213106C96232424 @default.
- W2916213106 hasIssue "4" @default.
- W2916213106 hasLocation W29162131061 @default.
- W2916213106 hasOpenAccess W2916213106 @default.
- W2916213106 hasPrimaryLocation W29162131061 @default.
- W2916213106 hasRelatedWork W1607681758 @default.
- W2916213106 hasRelatedWork W1950812539 @default.
- W2916213106 hasRelatedWork W1981555633 @default.
- W2916213106 hasRelatedWork W1996312262 @default.
- W2916213106 hasRelatedWork W1998233615 @default.
- W2916213106 hasRelatedWork W2019276845 @default.
- W2916213106 hasRelatedWork W2022265958 @default.
- W2916213106 hasRelatedWork W2038312722 @default.
- W2916213106 hasRelatedWork W2062496875 @default.
- W2916213106 hasRelatedWork W2078387542 @default.
- W2916213106 hasRelatedWork W2107920010 @default.
- W2916213106 hasRelatedWork W2128630935 @default.
- W2916213106 hasRelatedWork W2140264955 @default.
- W2916213106 hasRelatedWork W2141632019 @default.
- W2916213106 hasRelatedWork W2144854356 @default.
- W2916213106 hasRelatedWork W2231730923 @default.
- W2916213106 hasRelatedWork W2260790664 @default.
- W2916213106 hasRelatedWork W2284111497 @default.
- W2916213106 hasRelatedWork W2973955555 @default.
- W2916213106 hasRelatedWork W3009852766 @default.
- W2916213106 hasVolume "9" @default.
- W2916213106 isParatext "false" @default.
- W2916213106 isRetracted "false" @default.
- W2916213106 magId "2916213106" @default.
- W2916213106 workType "article" @default.