FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916253567> ?p ?o ?g. }

• W2916253567 abstract "Background: Gait imbalance and oscillopsia are frequent complaints of bilateral vestibular loss (BLV). Video-head-impulse testing (vHIT) of all six semicircular canals (SCCs) has demonstrated varying involvement of the different canals. Sparing of anterior-canal function has been linked to aminoglycoside-related vestibulopathy and Menière's disease. We hypothesized that utricular and saccular impairment (assessed by vestibular-evoked myogenic-potentials; VEMPs) may be disease-specific also, possibly facilitating the differential diagnosis. Methods: We searched our vHIT-database (n=3271) for patients with bilaterally impaired SCC-function who also received ocular VEMPs (oVEMPs) and cervical VEMPs (cVEMPs) and identified 101 patients. oVEMP/cVEMP-latencies above the 95th-percentile and peak-to-peak amplitudes below the 5th-percentile of normal were considered abnormal. Frequency of impairment of vestibular end organs (horizontal/anterior/posterior SCC, utriculus/sacculus) was analyzed with hierarchical cluster analysis and correlated with the underlying etiology. Results: Rates of utricular and saccular loss-of-function were similar (87.1% vs. 78.2%, p=0.136, Fisher's exact test). oVEMP-abnormalities were found more frequent in aminoglycoside-related BVL compared to Menière's disease (91.7% vs. 54.6%, p=0.039). Hierarchical cluster analysis indicated distinct patterns of vestibular end-organ impairment, showing that the results for the same end-organs on both sides are more similar than to other end-organs. Relative sparing of anterior-canal function was reflected in late merging with the other end-organs, emphasizing their distinct state. An anatomically corresponding pattern of SCC/otolith hypofunction was present in 60.4% (oVEMPs vs. horizontal SCCs), 34.7% (oVEMPs vs. anterior SCCs) and 48.5% (cVEMPs vs. posterior SCCs) of cases. Average (±1SD) number of damaged sensors was 6.8±2.2 out of 10. Significantly (p<0.001) more sensors were impaired in patients with aminoglycoside-related BVL (8.1±1.2) or inner-ear infections (8.7±1.8) compared to Menière-related BVL (5.5±1.5). Discussion: Hierarchical cluster analysis may help differentiate characteristic patterns of BVL. With a prevalence of ≈80%, utricular and/or saccular impairment is frequent in BVL. The extent of SCC and otolith impairment was disease-dependent, showing most extensive damage in BVL related to inner-ear infection and aminoglycoside-exposure and more selective impairment in Menière's disease. Specifically, assessing utricular function may help in the distinction between aminoglycoside-related BVL and bilateral Menière's disease." @default.
• W2916253567 created "2019-03-02" @default.
• W2916253567 creator A5014748846 @default.
• W2916253567 creator A5035868288 @default.
• W2916253567 creator A5067842871 @default.
• W2916253567 creator A5087790807 @default.
• W2916253567 date "2018-04-10" @default.
• W2916253567 modified "2023-09-26" @default.
• W2916253567 title "Hierarchical Cluster Analysis of Semicircular Canal and Otolith Deficits in Bilateral Vestibulopathy" @default.
• W2916253567 cites W1492410488 @default.
• W2916253567 cites W1493517647 @default.
• W2916253567 cites W1521287996 @default.
• W2916253567 cites W1775737973 @default.
• W2916253567 cites W1825094466 @default.
• W2916253567 cites W1967658251 @default.
• W2916253567 cites W1982845766 @default.
• W2916253567 cites W1994491457 @default.
• W2916253567 cites W2006379806 @default.
• W2916253567 cites W2010357544 @default.
• W2916253567 cites W2011265479 @default.
• W2916253567 cites W2015910279 @default.
• W2916253567 cites W2015969530 @default.
• W2916253567 cites W2016931939 @default.
• W2916253567 cites W2035998163 @default.
• W2916253567 cites W2037549986 @default.
• W2916253567 cites W2049616626 @default.
• W2916253567 cites W2053154970 @default.
• W2916253567 cites W2055792111 @default.
• W2916253567 cites W2063493753 @default.
• W2916253567 cites W2064941460 @default.
• W2916253567 cites W2069455690 @default.
• W2916253567 cites W2071269414 @default.
• W2916253567 cites W2084948560 @default.
• W2916253567 cites W2089838408 @default.
• W2916253567 cites W2139440503 @default.
• W2916253567 cites W2140541004 @default.
• W2916253567 cites W2168382574 @default.
• W2916253567 cites W2256410958 @default.
• W2916253567 cites W2280465013 @default.
• W2916253567 cites W2325054331 @default.
• W2916253567 cites W2333382274 @default.
• W2916253567 cites W2402737934 @default.
• W2916253567 cites W2415461190 @default.
• W2916253567 cites W2513610218 @default.
• W2916253567 cites W2614488200 @default.
• W2916253567 cites W2758384006 @default.
• W2916253567 cites W2776892961 @default.
• W2916253567 doi "https://doi.org/10.3389/fneur.2018.00244" @default.
• W2916253567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5902493" @default.
• W2916253567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29692756" @default.
• W2916253567 hasPublicationYear "2018" @default.
• W2916253567 type Work @default.
• W2916253567 sameAs 2916253567 @default.
• W2916253567 citedByCount "22" @default.
• W2916253567 countsByYear W29162535672019 @default.
• W2916253567 countsByYear W29162535672020 @default.
• W2916253567 countsByYear W29162535672021 @default.
• W2916253567 countsByYear W29162535672022 @default.
• W2916253567 countsByYear W29162535672023 @default.
• W2916253567 crossrefType "journal-article" @default.
• W2916253567 hasAuthorship W2916253567A5014748846 @default.
• W2916253567 hasAuthorship W2916253567A5035868288 @default.
• W2916253567 hasAuthorship W2916253567A5067842871 @default.
• W2916253567 hasAuthorship W2916253567A5087790807 @default.
• W2916253567 hasBestOaLocation W29162535671 @default.
• W2916253567 hasConcept C105702510 @default.
• W2916253567 hasConcept C190041318 @default.
• W2916253567 hasConcept C2776837582 @default.
• W2916253567 hasConcept C2777262511 @default.
• W2916253567 hasConcept C2777340575 @default.
• W2916253567 hasConcept C2778039178 @default.
• W2916253567 hasConcept C2778079943 @default.
• W2916253567 hasConcept C2780041246 @default.
• W2916253567 hasConcept C2909208804 @default.
• W2916253567 hasConcept C505870484 @default.
• W2916253567 hasConcept C548259974 @default.
• W2916253567 hasConcept C71924100 @default.
• W2916253567 hasConcept C86803240 @default.
• W2916253567 hasConceptScore W2916253567C105702510 @default.
• W2916253567 hasConceptScore W2916253567C190041318 @default.
• W2916253567 hasConceptScore W2916253567C2776837582 @default.
• W2916253567 hasConceptScore W2916253567C2777262511 @default.
• W2916253567 hasConceptScore W2916253567C2777340575 @default.
• W2916253567 hasConceptScore W2916253567C2778039178 @default.
• W2916253567 hasConceptScore W2916253567C2778079943 @default.
• W2916253567 hasConceptScore W2916253567C2780041246 @default.
• W2916253567 hasConceptScore W2916253567C2909208804 @default.
• W2916253567 hasConceptScore W2916253567C505870484 @default.
• W2916253567 hasConceptScore W2916253567C548259974 @default.
• W2916253567 hasConceptScore W2916253567C71924100 @default.
• W2916253567 hasConceptScore W2916253567C86803240 @default.
• W2916253567 hasLocation W29162535671 @default.
• W2916253567 hasLocation W29162535672 @default.
• W2916253567 hasLocation W29162535673 @default.
• W2916253567 hasLocation W29162535674 @default.
• W2916253567 hasLocation W29162535675 @default.
• W2916253567 hasLocation W29162535676 @default.
• W2916253567 hasOpenAccess W2916253567 @default.
• W2916253567 hasPrimaryLocation W29162535671 @default.
• W2916253567 hasRelatedWork W1208203720 @default.

• next