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- W2916306777 abstract "Phosphatidylinositol 3′-OH kinase (PI3K)-Akt and transcription factor NF-κB are important molecules involved in the regulation of cell proliferation, apoptosis, and oncogenesis. Both PI3K-Akt and Nuclear Factor-kappaB (NF-κB) are involved in the development and progression of prostate cancer, however, the crosstalk and molecules connecting these pathway remains unclear. A multilevel system representation of the PI3K-Akt and NF-κB pathways was constructed to determine which signaling components contribute to adaptive behavior and coordination. In silico experiments conducted using PI3K-Akt and NF-κB, mathematical models were modularized using biological functionality and were validated using a cell culture system. Our analysis demonstrates that a component representing the IκB kinase (IKK) complex can coordinate these two pathways. It is expected that interruption of this molecule could represent a potential therapeutic target for prostate cancer." @default.
- W2916306777 created "2019-03-02" @default.
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- W2916306777 date "2019-02-26" @default.
- W2916306777 modified "2023-10-18" @default.
- W2916306777 title "Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer" @default.
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- W2916306777 doi "https://doi.org/10.3390/cells8030201" @default.
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