FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916390096> ?p ?o ?g. }

• W2916390096 abstract "The intestinal mucosa in inflammatory bowel disease (IBD) contains increased frequencies of lymphocytes and a disproportionate increase in plasma cells secreting immunoglobulin (Ig)G relative to other isotypes compared to healthy controls. Despite consistent evidence of B lineage cells in the mucosa in IBD, little is known of B cell recruitment to the gut in IBD. Here we analysed B cells in blood of patients with Crohn’s disease (CD) and ulcerative colitis (UC) with a range of disease activities. We analysed the frequencies of known B cell subsets in blood and observed a consistent reduction in the proportion of CD27-IgD- B cells expressing all Ig isotypes in the blood in IBD (independent of severity of disease and treatment) compared to healthy controls. Successful treatment of patients with biologic therapies did not change the profile of B cell subsets in blood. By mass cytometry we demonstrated that CD27-IgD- B cells were proportionately enriched in the gut-associated lymphoid tissue (GALT) in IBD. Since production of TNF is a feature of IBD relevant to therapies, we sought to determine whether B cells in GALT or the CD27-IgD- subset in particular could contribute to pathology by secretion of TNF or IL-10. We found that donor matched GALT and blood B cells are capable of producing TNF as well as IL-10, but we saw no evidence that CD27-IgD- B cells from blood expressed more TNF compared to other subsets. The reduced proportion of CD27-IgD- B cells in blood and the increased proportion in the gut implies that CD27-IgD- B cells are recruited from the blood to the gut in IBD. CD27-IgD- B cells have been implicated in immune responses to intestinal bacteria and recruitment to GALT, and may contribute to the intestinal inflammatory milieu in IBD." @default.
• W2916390096 created "2019-03-02" @default.
• W2916390096 creator A5001940767 @default.
• W2916390096 creator A5016644184 @default.
• W2916390096 creator A5017628987 @default.
• W2916390096 creator A5028593271 @default.
• W2916390096 creator A5040628427 @default.
• W2916390096 creator A5042407355 @default.
• W2916390096 creator A5042467158 @default.
• W2916390096 creator A5043915683 @default.
• W2916390096 creator A5064643031 @default.
• W2916390096 creator A5067624403 @default.
• W2916390096 creator A5081638258 @default.
• W2916390096 creator A5089109226 @default.
• W2916390096 date "2019-03-05" @default.
• W2916390096 modified "2023-10-11" @default.
• W2916390096 title "Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease" @default.
• W2916390096 cites W1810076817 @default.
• W2916390096 cites W1938587120 @default.
• W2916390096 cites W1965272893 @default.
• W2916390096 cites W1996845889 @default.
• W2916390096 cites W2003048186 @default.
• W2916390096 cites W2015391967 @default.
• W2916390096 cites W2016432359 @default.
• W2916390096 cites W2022661087 @default.
• W2916390096 cites W2036630215 @default.
• W2916390096 cites W2067315938 @default.
• W2916390096 cites W2073022365 @default.
• W2916390096 cites W2078621117 @default.
• W2916390096 cites W2081081749 @default.
• W2916390096 cites W2091389437 @default.
• W2916390096 cites W2096300483 @default.
• W2916390096 cites W2098426068 @default.
• W2916390096 cites W2107093945 @default.
• W2916390096 cites W2112129392 @default.
• W2916390096 cites W2118416525 @default.
• W2916390096 cites W2129806278 @default.
• W2916390096 cites W2130405999 @default.
• W2916390096 cites W2130699403 @default.
• W2916390096 cites W2134871263 @default.
• W2916390096 cites W2156049613 @default.
• W2916390096 cites W2157272219 @default.
• W2916390096 cites W2161753987 @default.
• W2916390096 cites W2164510587 @default.
• W2916390096 cites W2166356293 @default.
• W2916390096 cites W2201859789 @default.
• W2916390096 cites W2321205867 @default.
• W2916390096 cites W2521071485 @default.
• W2916390096 cites W2548437636 @default.
• W2916390096 cites W2548791670 @default.
• W2916390096 cites W2612927375 @default.
• W2916390096 cites W2615033049 @default.
• W2916390096 cites W2751607427 @default.
• W2916390096 cites W2801709134 @default.
• W2916390096 cites W2807902520 @default.
• W2916390096 cites W2889787113 @default.
• W2916390096 cites W2891329059 @default.
• W2916390096 cites W4244626580 @default.
• W2916390096 cites W4251066823 @default.
• W2916390096 doi "https://doi.org/10.3389/fimmu.2019.00361" @default.
• W2916390096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6411645" @default.
• W2916390096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30891036" @default.
• W2916390096 hasPublicationYear "2019" @default.
• W2916390096 type Work @default.
• W2916390096 sameAs 2916390096 @default.
• W2916390096 citedByCount "29" @default.
• W2916390096 countsByYear W29163900962020 @default.
• W2916390096 countsByYear W29163900962021 @default.
• W2916390096 countsByYear W29163900962022 @default.
• W2916390096 countsByYear W29163900962023 @default.
• W2916390096 crossrefType "journal-article" @default.
• W2916390096 hasAuthorship W2916390096A5001940767 @default.
• W2916390096 hasAuthorship W2916390096A5016644184 @default.
• W2916390096 hasAuthorship W2916390096A5017628987 @default.
• W2916390096 hasAuthorship W2916390096A5028593271 @default.
• W2916390096 hasAuthorship W2916390096A5040628427 @default.
• W2916390096 hasAuthorship W2916390096A5042407355 @default.
• W2916390096 hasAuthorship W2916390096A5042467158 @default.
• W2916390096 hasAuthorship W2916390096A5043915683 @default.
• W2916390096 hasAuthorship W2916390096A5064643031 @default.
• W2916390096 hasAuthorship W2916390096A5067624403 @default.
• W2916390096 hasAuthorship W2916390096A5081638258 @default.
• W2916390096 hasAuthorship W2916390096A5089109226 @default.
• W2916390096 hasBestOaLocation W29163900961 @default.
• W2916390096 hasConcept C126322002 @default.
• W2916390096 hasConcept C159654299 @default.
• W2916390096 hasConcept C181152851 @default.
• W2916390096 hasConcept C203014093 @default.
• W2916390096 hasConcept C2778260677 @default.
• W2916390096 hasConcept C2778453870 @default.
• W2916390096 hasConcept C2779134260 @default.
• W2916390096 hasConcept C2780479503 @default.
• W2916390096 hasConcept C48010095 @default.
• W2916390096 hasConcept C71924100 @default.
• W2916390096 hasConcept C86803240 @default.
• W2916390096 hasConceptScore W2916390096C126322002 @default.
• W2916390096 hasConceptScore W2916390096C159654299 @default.
• W2916390096 hasConceptScore W2916390096C181152851 @default.
• W2916390096 hasConceptScore W2916390096C203014093 @default.
• W2916390096 hasConceptScore W2916390096C2778260677 @default.

• next