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• W2916407853 abstract "Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disease, in which immune defects can occur at multiple points of the cascading auto‐aggressive immune reactions, resulting in a striking heterogeneity of clinical presentations. The clinical manifestations of such autoimmune response can be severe: common manifestations symptoms include rash and renal inflammation progressing to kidney failure. Autophagy, the cellular “self‐digestion” process, is a key factor in the interplay between innate and adaptive immunity. Dysregulation of autophagy has been implicated in numerous autoimmune diseases. Several lines of evidence from genomic studies, cell culture systems, animal models, and human patients are emerging to support the role of autophagy in progression and pathogenesis of SLE. In this review, we summarize recent key findings on the aberrations of autophagy in SLE, with a special focus on how deregulated autophagy promotes autoimmunity and renal damage. We will also discuss how the observed findings may be translated into therapeutic settings." @default.
• W2916407853 created "2019-03-02" @default.
• W2916407853 creator A5004705549 @default.
• W2916407853 creator A5007122446 @default.
• W2916407853 creator A5069849278 @default.
• W2916407853 date "2019-02-25" @default.
• W2916407853 modified "2023-10-16" @default.
• W2916407853 title "Autophagy and immunological aberrations in systemic lupus erythematosus" @default.
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