FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916432893> ?p ?o ?g. }

• W2916432893 abstract "The Wnt gene family members are known to participate regulating various normal and pathological processes including tumorigenesis. However, the association between Wnt ligands gene family and prognosis in hepatocellular carcinoma has not been systematically studied. Therefore, we evaluated the role of Wnt ligands gene family in hepatocellular carcinoma using publicly available data from The Cancer Genome Atlas (TCGA).Clinical information and RNA-Seq mRNA expression data were derived from TCGA hepatocellular carcinoma cohort. Differences in overall survival (OS) and disease-free survival (DFS) between increased and decreased expression groups (defined by X-tile analyses) of Wnt ligands gene family were compared using Kaplan-Meier method and Cox regression model, with p-values calculated via log-rank test. Gene Set Enrichment Analysis (GSEA) was performed.Multivariate analysis adjusted for patient age, sex, BMI, tumor grade, and TMN stage revealed that Wnt1, Wnt3 and Wnt5B expressions were independent prognostic factors for OS and DFS (OS: HR = 0.58, P = 0.006; HR = 0.65, P = 0.03; HR = 0.56, P = 0.023, respectively; DFS: HR = 0.52, P < 0.001; HR = 1.93, P = 0.003; HR = 0.59, P = 0.011, respectively). Furthermore, expression of Wnt1 and Wnt5B was significantly associated with TMN stage (P = 0.02 and P = 0.03 for OS; P = 0.02 and P = 0.02 for DFS). GSEA showed that nucleotide excision repair was differentially enriched in Wnt1 low expression phenotype and aminoacyl trna biosynthesis and basal transcription factors were differentially enriched in Wnt5B low expression phenotype.Our results identified associations of several Wnt ligands with prognosis of HCC patients, indicating that these genes could serve as prognostic biomarkers of HCC." @default.
• W2916432893 created "2019-03-02" @default.
• W2916432893 creator A5058273573 @default.
• W2916432893 creator A5068881223 @default.
• W2916432893 creator A5079375772 @default.
• W2916432893 date "2019-02-15" @default.
• W2916432893 modified "2023-10-18" @default.
• W2916432893 title "Expression of the Wnt ligands gene family and its relationship to prognosis in hepatocellular carcinoma" @default.
• W2916432893 cites W1780615788 @default.
• W2916432893 cites W1968726675 @default.
• W2916432893 cites W1971085650 @default.
• W2916432893 cites W1971402898 @default.
• W2916432893 cites W1974942829 @default.
• W2916432893 cites W2016373982 @default.
• W2916432893 cites W2027428196 @default.
• W2916432893 cites W2056378508 @default.
• W2916432893 cites W2059139509 @default.
• W2916432893 cites W2059509996 @default.
• W2916432893 cites W2061961694 @default.
• W2916432893 cites W2064024065 @default.
• W2916432893 cites W2084369408 @default.
• W2916432893 cites W2097240638 @default.
• W2916432893 cites W2099011309 @default.
• W2916432893 cites W2101151609 @default.
• W2916432893 cites W2101977418 @default.
• W2916432893 cites W2127754060 @default.
• W2916432893 cites W2128000298 @default.
• W2916432893 cites W2130410032 @default.
• W2916432893 cites W2133650808 @default.
• W2916432893 cites W2139978929 @default.
• W2916432893 cites W2146122330 @default.
• W2916432893 cites W2149927639 @default.
• W2916432893 cites W2151789140 @default.
• W2916432893 cites W2152347253 @default.
• W2916432893 cites W2157313762 @default.
• W2916432893 cites W2171403380 @default.
• W2916432893 cites W2277004004 @default.
• W2916432893 cites W2290767614 @default.
• W2916432893 cites W2312709749 @default.
• W2916432893 cites W2335051739 @default.
• W2916432893 cites W2341950863 @default.
• W2916432893 cites W2461803522 @default.
• W2916432893 cites W2474310477 @default.
• W2916432893 cites W2475121750 @default.
• W2916432893 cites W2509014393 @default.
• W2916432893 cites W2516399990 @default.
• W2916432893 cites W2523138182 @default.
• W2916432893 cites W2525359987 @default.
• W2916432893 cites W2552665973 @default.
• W2916432893 cites W2598089221 @default.
• W2916432893 cites W2616140900 @default.
• W2916432893 cites W2619400800 @default.
• W2916432893 cites W2625559053 @default.
• W2916432893 cites W2734438658 @default.
• W2916432893 cites W2761031851 @default.
• W2916432893 cites W2762855963 @default.
• W2916432893 cites W2780677122 @default.
• W2916432893 cites W2789544747 @default.
• W2916432893 cites W2796111179 @default.
• W2916432893 cites W2804673440 @default.
• W2916432893 cites W2804700695 @default.
• W2916432893 cites W3015238454 @default.
• W2916432893 cites W3149478864 @default.
• W2916432893 doi "https://doi.org/10.1186/s12935-019-0743-z" @default.
• W2916432893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6376661" @default.
• W2916432893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30814912" @default.
• W2916432893 hasPublicationYear "2019" @default.
• W2916432893 type Work @default.
• W2916432893 sameAs 2916432893 @default.
• W2916432893 citedByCount "11" @default.
• W2916432893 countsByYear W29164328932019 @default.
• W2916432893 countsByYear W29164328932020 @default.
• W2916432893 countsByYear W29164328932021 @default.
• W2916432893 countsByYear W29164328932022 @default.
• W2916432893 countsByYear W29164328932023 @default.
• W2916432893 crossrefType "journal-article" @default.
• W2916432893 hasAuthorship W2916432893A5058273573 @default.
• W2916432893 hasAuthorship W2916432893A5068881223 @default.
• W2916432893 hasAuthorship W2916432893A5079375772 @default.
• W2916432893 hasBestOaLocation W29164328931 @default.
• W2916432893 hasConcept C104317684 @default.
• W2916432893 hasConcept C121608353 @default.
• W2916432893 hasConcept C126322002 @default.
• W2916432893 hasConcept C127716648 @default.
• W2916432893 hasConcept C137620995 @default.
• W2916432893 hasConcept C143998085 @default.
• W2916432893 hasConcept C150194340 @default.
• W2916432893 hasConcept C2778019345 @default.
• W2916432893 hasConcept C502942594 @default.
• W2916432893 hasConcept C50382708 @default.
• W2916432893 hasConcept C54355233 @default.
• W2916432893 hasConcept C555283112 @default.
• W2916432893 hasConcept C71924100 @default.
• W2916432893 hasConcept C86803240 @default.
• W2916432893 hasConceptScore W2916432893C104317684 @default.
• W2916432893 hasConceptScore W2916432893C121608353 @default.
• W2916432893 hasConceptScore W2916432893C126322002 @default.
• W2916432893 hasConceptScore W2916432893C127716648 @default.
• W2916432893 hasConceptScore W2916432893C137620995 @default.
• W2916432893 hasConceptScore W2916432893C143998085 @default.

• next