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• W2916462873 abstract "Abstract Macrophages constitute one of the most common components of immune cells, which penetrate tumors and they have a key role in tumor prognosis. Here, we identified an unrecognized macrophage subpopulation, which favors tumorigenesis. These macrophages express programmed cell death protein 1 (PD1) in a constitutive manner and accumulates in esophageal squamous cell carcinoma (ESCC) in advanced stage of the disease and is negatively associated with the survival of ESCC patients. The PD1 + tumor-associated macrophages (PD1 + TAMs) displayed surface pattern and function akin to M2: a substantial enhancement in CD206 and IL-10 expression; a specific reduction in HLA-DR, CD64, and IL-12 expression; and a significant increase in the ability to inhibit CD8 + T-cell proliferation. Triggering of PD1 signal is effective in increasing PD1 + TAM function. Moreover, exosomal HMGB1 obtained from tumors are efficient in triggering differentiation of monocytes into PD1 + TAMs, which display phenotypic and functional properties of M2. Overall, our work is the first finding to confirm that exosomal HMGB1 obtained from ESCC can successfully trigger clonal expansion of PD1 + TAM. Further, as the macrophages exhibit an M2-like surface profile and function, thereby creating conditions for development of ESCC. Thus, effective methods of treatment include combining immunotherapy with targeting PD1 + TAMs and tumor-derived exosomal HMGB1 to resuscitate immune function in individuals suffering from ESCC." @default.
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• W2916462873 date "2019-02-22" @default.
• W2916462873 modified "2023-10-17" @default.
• W2916462873 title "Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion" @default.
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• W2916462873 doi "https://doi.org/10.1038/s41389-019-0126-2" @default.
• W2916462873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386749" @default.
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