Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916485763> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2916485763 endingPage "104" @default.
- W2916485763 startingPage "101" @default.
- W2916485763 abstract "Congenital hypothyroidism (CH) is a highly prevalent but treatable neonatal endocrine disorder. Thyroid peroxidase (TPO) catalyzes key reactions in thyroid hormone (TH) synthesis. TPO mutations have been found to underlie approximately 5% of congenital hypothyroidism in Chinese patients with more severe phenotypes, the treatment of whom usually requires a higher dose of L-thyroxine. The Tpo gene of zebrafish has 66% homology with the human TPO gene, and synteny analysis has indicated that it is likely a human TPO ortholog. In this study, we generated a tpo-/- mutant zebrafish line through knockout of tpo with CRISPR/Cas9 and investigated the associated phenotypes. Tpo-/- mutant zebrafish displayed growth retardation; an increased number of thyroid follicular cells; and abnormal extrathyroidal phenotypes including pigmentation defects, erythema in the thoracic region, delayed scale development and failure of swim bladder secondary lobe formation. All these abnormal phenotypes were reversed by 30 nM thyroxine (T4) treatment starting at 1 month of age. Tpo-/- mutants also showed increased glucose levels during larval stages, and the increases were induced at least in part by increasing glucagon and decreasing insulin expression. Our work indicates that tpo-mutant zebrafish may serve as a human congenital hypothyroidism model for studying TPO- and TH-related disease mechanisms." @default.
- W2916485763 created "2019-03-02" @default.
- W2916485763 creator A5001018223 @default.
- W2916485763 creator A5011837982 @default.
- W2916485763 creator A5030770010 @default.
- W2916485763 creator A5049735056 @default.
- W2916485763 creator A5052219456 @default.
- W2916485763 creator A5069327388 @default.
- W2916485763 creator A5072438840 @default.
- W2916485763 date "2019-02-01" @default.
- W2916485763 modified "2023-10-16" @default.
- W2916485763 title "Targeted knockout of duox causes defects in zebrafish growth, thyroid development, and social interaction" @default.
- W2916485763 cites W1985490660 @default.
- W2916485763 cites W1989605956 @default.
- W2916485763 cites W2014477663 @default.
- W2916485763 cites W2025894647 @default.
- W2916485763 cites W2030925163 @default.
- W2916485763 cites W2038032147 @default.
- W2916485763 cites W2038915039 @default.
- W2916485763 cites W2052704661 @default.
- W2916485763 cites W2052920675 @default.
- W2916485763 cites W2055768712 @default.
- W2916485763 cites W2071872378 @default.
- W2916485763 cites W2087647428 @default.
- W2916485763 cites W2205767767 @default.
- W2916485763 cites W2327543792 @default.
- W2916485763 cites W2482548459 @default.
- W2916485763 cites W2626775677 @default.
- W2916485763 cites W2727087228 @default.
- W2916485763 cites W2758804004 @default.
- W2916485763 cites W2790323571 @default.
- W2916485763 doi "https://doi.org/10.1016/j.jgg.2019.01.004" @default.
- W2916485763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30867122" @default.
- W2916485763 hasPublicationYear "2019" @default.
- W2916485763 type Work @default.
- W2916485763 sameAs 2916485763 @default.
- W2916485763 citedByCount "7" @default.
- W2916485763 countsByYear W29164857632020 @default.
- W2916485763 countsByYear W29164857632021 @default.
- W2916485763 countsByYear W29164857632022 @default.
- W2916485763 countsByYear W29164857632023 @default.
- W2916485763 crossrefType "journal-article" @default.
- W2916485763 hasAuthorship W2916485763A5001018223 @default.
- W2916485763 hasAuthorship W2916485763A5011837982 @default.
- W2916485763 hasAuthorship W2916485763A5030770010 @default.
- W2916485763 hasAuthorship W2916485763A5049735056 @default.
- W2916485763 hasAuthorship W2916485763A5052219456 @default.
- W2916485763 hasAuthorship W2916485763A5069327388 @default.
- W2916485763 hasAuthorship W2916485763A5072438840 @default.
- W2916485763 hasConcept C104317684 @default.
- W2916485763 hasConcept C126322002 @default.
- W2916485763 hasConcept C127716648 @default.
- W2916485763 hasConcept C134018914 @default.
- W2916485763 hasConcept C2776878037 @default.
- W2916485763 hasConcept C2779258352 @default.
- W2916485763 hasConcept C526584372 @default.
- W2916485763 hasConcept C54355233 @default.
- W2916485763 hasConcept C68838962 @default.
- W2916485763 hasConcept C71924100 @default.
- W2916485763 hasConcept C86803240 @default.
- W2916485763 hasConceptScore W2916485763C104317684 @default.
- W2916485763 hasConceptScore W2916485763C126322002 @default.
- W2916485763 hasConceptScore W2916485763C127716648 @default.
- W2916485763 hasConceptScore W2916485763C134018914 @default.
- W2916485763 hasConceptScore W2916485763C2776878037 @default.
- W2916485763 hasConceptScore W2916485763C2779258352 @default.
- W2916485763 hasConceptScore W2916485763C526584372 @default.
- W2916485763 hasConceptScore W2916485763C54355233 @default.
- W2916485763 hasConceptScore W2916485763C68838962 @default.
- W2916485763 hasConceptScore W2916485763C71924100 @default.
- W2916485763 hasConceptScore W2916485763C86803240 @default.
- W2916485763 hasFunder F4320322120 @default.
- W2916485763 hasIssue "2" @default.
- W2916485763 hasLocation W29164857631 @default.
- W2916485763 hasLocation W29164857632 @default.
- W2916485763 hasOpenAccess W2916485763 @default.
- W2916485763 hasPrimaryLocation W29164857631 @default.
- W2916485763 hasRelatedWork W1981968121 @default.
- W2916485763 hasRelatedWork W2011960454 @default.
- W2916485763 hasRelatedWork W2021841321 @default.
- W2916485763 hasRelatedWork W2060603500 @default.
- W2916485763 hasRelatedWork W2070295037 @default.
- W2916485763 hasRelatedWork W2072870574 @default.
- W2916485763 hasRelatedWork W2155312245 @default.
- W2916485763 hasRelatedWork W2163236351 @default.
- W2916485763 hasRelatedWork W2411536504 @default.
- W2916485763 hasRelatedWork W2793777692 @default.
- W2916485763 hasVolume "46" @default.
- W2916485763 isParatext "false" @default.
- W2916485763 isRetracted "false" @default.
- W2916485763 magId "2916485763" @default.
- W2916485763 workType "article" @default.