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- W2916511243 endingPage "180" @default.
- W2916511243 startingPage "146" @default.
- W2916511243 abstract "Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic indications, including neurodegenerative disorders. A broader understanding of the impact of nanomedicines design is now required to enhance their translational potential. Nanoformulations in vivo journey is significantly affected by their physicochemical properties including the size, shape, hydrophobicity, elasticity, and surface charge/chemistry/morphology, which play a role as an interface with the biological environment. Understanding protein corona formation is crucial in characterizing nanocarriers and evaluating their interactions with biological systems. In this review, the types and properties of the brain-targeted nanocarriers are discussed. The biological factors and nanocarriers properties affecting their in vivo behavior are elaborated. The compositional description of cell culture and biological matrices, including proteins potentially relevant to protein corona built-up on nanoformulation especially for brain administration, is provided. Analytical techniques of characterizing nanocarriers in complex matrices, their advantages, limitations, and implementation challenges in industrial GMP environment are discussed. The uses of orthogonal complementary characterization approaches of nanocarriers are also covered." @default.
- W2916511243 created "2019-03-02" @default.
- W2916511243 creator A5006405586 @default.
- W2916511243 creator A5038702040 @default.
- W2916511243 creator A5061421611 @default.
- W2916511243 creator A5068205502 @default.
- W2916511243 date "2019-08-01" @default.
- W2916511243 modified "2023-10-18" @default.
- W2916511243 title "Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential" @default.
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