FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916563339> ?p ?o ?g. }

• W2916563339 abstract "Flavonoids have important developmental, physiological, and ecological roles in plants and are primarily stored in the large central vacuole. Here we show that both an ATP-binding cassette (ABC) transporter(s) and an H+-antiporter(s) are involved in the uptake of cyanidin 3-O-glucoside (C3G) by Arabidopsis vacuolar membrane-enriched vesicles. We also demonstrate that vesicles isolated from yeast expressing the ABC protein AtABCC2 are capable of MgATP-dependent uptake of C3G and other anthocyanins. The uptake of C3G by AtABCC2 depended on the co-transport of glutathione (GSH). C3G was not altered during transport and a GSH conjugate was not formed. Vesicles from yeast expressing AtABCC2 also transported flavone and flavonol glucosides. We performed ligand docking studies to a homology model of AtABCC2 and probed the putative binding sites of C3G and GSH through site-directed mutagenesis and functional studies. These studies identified residues important for substrate recognition and transport activity in AtABCC2, and suggest that C3G and GSH bind closely, mutually enhancing each other’s binding. In conclusion, we suggest that AtABCC2 along with possibly other ABCC proteins are involved in the vacuolar transport of anthocyanins and other flavonoids in the vegetative tissue of Arabidopsis." @default.
• W2916563339 created "2019-03-02" @default.
• W2916563339 creator A5023723842 @default.
• W2916563339 creator A5031872815 @default.
• W2916563339 creator A5073941540 @default.
• W2916563339 creator A5090163958 @default.
• W2916563339 creator A5090795414 @default.
• W2916563339 date "2019-01-24" @default.
• W2916563339 modified "2023-10-15" @default.
• W2916563339 title "Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2" @default.
• W2916563339 cites W1444513792 @default.
• W2916563339 cites W1521785965 @default.
• W2916563339 cites W1639721376 @default.
• W2916563339 cites W1788495197 @default.
• W2916563339 cites W1921938709 @default.
• W2916563339 cites W1965410481 @default.
• W2916563339 cites W1971668303 @default.
• W2916563339 cites W1972060131 @default.
• W2916563339 cites W1980168309 @default.
• W2916563339 cites W1984792166 @default.
• W2916563339 cites W1993092556 @default.
• W2916563339 cites W1995500412 @default.
• W2916563339 cites W1996968444 @default.
• W2916563339 cites W1999793523 @default.
• W2916563339 cites W2000982743 @default.
• W2916563339 cites W2001058688 @default.
• W2916563339 cites W2001796950 @default.
• W2916563339 cites W2006176190 @default.
• W2916563339 cites W2010242646 @default.
• W2916563339 cites W2010398938 @default.
• W2916563339 cites W2011032227 @default.
• W2916563339 cites W2020971073 @default.
• W2916563339 cites W2026265784 @default.
• W2916563339 cites W2034356567 @default.
• W2916563339 cites W2043132831 @default.
• W2916563339 cites W204398758 @default.
• W2916563339 cites W2044569209 @default.
• W2916563339 cites W2052214989 @default.
• W2916563339 cites W2057663365 @default.
• W2916563339 cites W2057894657 @default.
• W2916563339 cites W2073670601 @default.
• W2916563339 cites W2074073932 @default.
• W2916563339 cites W2074172261 @default.
• W2916563339 cites W2076248870 @default.
• W2916563339 cites W2082545023 @default.
• W2916563339 cites W2083003041 @default.
• W2916563339 cites W2093461890 @default.
• W2916563339 cites W2097847369 @default.
• W2916563339 cites W2099540110 @default.
• W2916563339 cites W2100558136 @default.
• W2916563339 cites W2107957559 @default.
• W2916563339 cites W2110824674 @default.
• W2916563339 cites W2112660950 @default.
• W2916563339 cites W2113968207 @default.
• W2916563339 cites W2115831900 @default.
• W2916563339 cites W2118305958 @default.
• W2916563339 cites W2120946446 @default.
• W2916563339 cites W2122221811 @default.
• W2916563339 cites W2122706928 @default.
• W2916563339 cites W2124604090 @default.
• W2916563339 cites W2125995390 @default.
• W2916563339 cites W2127816774 @default.
• W2916563339 cites W2136797184 @default.
• W2916563339 cites W2138620717 @default.
• W2916563339 cites W2151765317 @default.
• W2916563339 cites W2157808629 @default.
• W2916563339 cites W2158213604 @default.
• W2916563339 cites W2158588385 @default.
• W2916563339 cites W2163388941 @default.
• W2916563339 cites W2164050810 @default.
• W2916563339 cites W2169181123 @default.
• W2916563339 cites W2221519947 @default.
• W2916563339 cites W2731134485 @default.
• W2916563339 cites W2740713512 @default.
• W2916563339 cites W4246962760 @default.
• W2916563339 cites W4293247451 @default.
• W2916563339 doi "https://doi.org/10.1038/s41598-018-37504-8" @default.
• W2916563339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345954" @default.
• W2916563339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30679715" @default.
• W2916563339 hasPublicationYear "2019" @default.
• W2916563339 type Work @default.
• W2916563339 sameAs 2916563339 @default.
• W2916563339 citedByCount "62" @default.
• W2916563339 countsByYear W29165633392020 @default.
• W2916563339 countsByYear W29165633392021 @default.
• W2916563339 countsByYear W29165633392022 @default.
• W2916563339 countsByYear W29165633392023 @default.
• W2916563339 crossrefType "journal-article" @default.
• W2916563339 hasAuthorship W2916563339A5023723842 @default.
• W2916563339 hasAuthorship W2916563339A5031872815 @default.
• W2916563339 hasAuthorship W2916563339A5073941540 @default.
• W2916563339 hasAuthorship W2916563339A5090163958 @default.
• W2916563339 hasAuthorship W2916563339A5090795414 @default.
• W2916563339 hasBestOaLocation W29165633391 @default.
• W2916563339 hasConcept C104317684 @default.
• W2916563339 hasConcept C143065580 @default.
• W2916563339 hasConcept C149011108 @default.
• W2916563339 hasConcept C185592680 @default.
• W2916563339 hasConcept C2779491563 @default.
• W2916563339 hasConcept C44312359 @default.

• next