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• W2916576266 abstract "RNA binding proteins regulate gene expression through several post-transcriptional mechanisms. The broadly expressed HuR/ELAVL1 is important for proper function of multiple immune cell types, and has been proposed to regulate cytokine and other mRNA 3' UTRs upon activation. However, this mechanism has not been previously dissected in stable cellular settings. In this study, HuR demonstrated strong anti-apoptotic and activation roles in Jurkat T cells. Detailed transcriptomic analysis of HuR knockout cells revealed a substantial negative impact on the activation program, coordinately preventing the expression of immune response gene categories, including all cytokines. Knockout cells showed a significant defect in IL-2 production, which was rescued upon reintroduction of HuR. Interestingly, the mechanism of HuR regulation did not involve control of the cytokine 3' UTRs: HuR knockout did not affect the activity of 3' UTR reporters in 293 cells, and had no effect on IL-2 and TNF 3' UTRs in resting or activated Jurkats. Instead, impaired cytokine production corresponded with defective induction of the IL-2 promoter upon activation. Accordingly, upregulation of NFATC1 was also impaired, without 3' UTR effects. Together, these results indicate that HuR controls cytokine production through coordinated upstream pathways, and that additional mechanisms must be considered in investigating its function." @default.
• W2916576266 created "2019-03-02" @default.
• W2916576266 creator A5081767938 @default.
• W2916576266 date "2019-03-04" @default.
• W2916576266 modified "2023-09-24" @default.
• W2916576266 title "HuR controls apoptosis and activation response without effects on cytokine 3’ UTRs" @default.
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• W2916576266 cites W1591868490 @default.
• W2916576266 cites W1595404381 @default.
• W2916576266 cites W1710916447 @default.
• W2916576266 cites W1788342631 @default.
• W2916576266 cites W1887878037 @default.
• W2916576266 cites W1905518110 @default.
• W2916576266 cites W1964170234 @default.
• W2916576266 cites W1973480874 @default.
• W2916576266 cites W1973614363 @default.
• W2916576266 cites W1980107542 @default.
• W2916576266 cites W1982925662 @default.
• W2916576266 cites W1988097332 @default.
• W2916576266 cites W1989263240 @default.
• W2916576266 cites W1991210089 @default.
• W2916576266 cites W1991401817 @default.
• W2916576266 cites W1993210315 @default.
• W2916576266 cites W1993691900 @default.
• W2916576266 cites W1997272400 @default.
• W2916576266 cites W2004431585 @default.
• W2916576266 cites W2005558505 @default.
• W2916576266 cites W2009644403 @default.
• W2916576266 cites W2012112428 @default.
• W2916576266 cites W2012316243 @default.
• W2916576266 cites W2016450373 @default.
• W2916576266 cites W2018542343 @default.
• W2916576266 cites W2020081155 @default.
• W2916576266 cites W2025296756 @default.
• W2916576266 cites W2028493513 @default.
• W2916576266 cites W2029706883 @default.
• W2916576266 cites W2034117623 @default.
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• W2916576266 cites W2039298735 @default.
• W2916576266 cites W2049462796 @default.
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• W2916576266 cites W2069066096 @default.
• W2916576266 cites W2073580835 @default.
• W2916576266 cites W2085555782 @default.
• W2916576266 cites W2090009109 @default.
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• W2916576266 cites W2119204091 @default.
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• W2916576266 cites W2155146718 @default.
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• W2916576266 cites W2170551349 @default.
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• W2916576266 doi "https://doi.org/10.1080/15476286.2019.1582954" @default.
• W2916576266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546391" @default.
• W2916576266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30777501" @default.
• W2916576266 hasPublicationYear "2019" @default.
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