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- W2916584199 abstract "Many organs (skin, stomach, intestines, colon, and eye) possess an epithelial layer that is short-lived and rapidly lost, requiring a source of adult stem cells that produces a continual supply of epithelial cells to replenish the lost cells. Maintaining these rapidly self-renewing epithelial surfaces during normal homeostasis is therefore dependent upon the health of the adult stem cell population. One important challenge in regenerative medicine is replacing these adult stem cells when they are eliminated following an injury or disease. The eye contains two highly specialized stratified squamous epithelia, the conjunctival epithelium and the corneal epithelium, which are separated by the limbal epithelium (Fig. 5.1). A healthy corneal epithelium is essential for maintaining a clear cornea and normal vision. The limbus contains a small subpopulation of rare LSC (Limbal Stem Cells) that continually repopulates the corneal epithelium. Patients with a LSCD (Limbal Stem Cell Deficiency) are unable to regenerate the corneal epithelium, resulting in migration of the conjunctival epithelium over the corneal stroma, called “conjunctivalization,” that triggers neovascularization, chronic inflammation, and corneal opacity. A complete LSCD results in the total loss of the corneal epithelium and blindness due to an irreversibly opaque cornea. The extent of LSC loss can range from partial to complete and can be either unilateral or bilateral with a corresponding range in the loss of vision. LSCD can be caused by a variety of injuries or diseases: chemical or thermal burns [1], Stevens-Johnson syndrome [2, 3], aniridia [3], contact lens-induced keratopathy [4], multiple surgeries [5], cryotherapy of the limbus [5], chronic peripheral corneal inflammation [6], and lysosomal storage disease. However, corneal burns are by far the most frequent cause of a LSCD [5]." @default.
- W2916584199 created "2019-03-02" @default.
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- W2916584199 date "2018-01-01" @default.
- W2916584199 modified "2023-09-26" @default.
- W2916584199 title "Limbal Stem Cells and the Treatment of Limbal Stem Cell Deficiency" @default.
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- W2916584199 doi "https://doi.org/10.1007/978-3-319-98080-5_5" @default.
- W2916584199 hasPublicationYear "2018" @default.
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