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• W2916592801 abstract "Human kidney organoids hold promise for studying development, disease modelling and drug screening. However, the utility of stem cell-derived kidney tissues will depend on how faithfully these replicate normal fetal development at the level of cellular identity and complexity. Here, we present an integrated analysis of single cell datasets from human kidney organoids and human fetal kidney to assess similarities and differences between the component cell types. Clusters in the combined dataset contained cells from both organoid and fetal kidney with transcriptional congruence for key stromal, endothelial and nephron cell type-specific markers. Organoid enriched neural, glial and muscle progenitor populations were also evident. Major transcriptional differences between organoid and human tissue were likely related to technical artefacts. Cell type-specific comparisons revealed differences in stromal, endothelial and nephron progenitor cell types including expression of WNT2B in the human fetal kidney stroma. This study supports the fidelity of kidney organoids as models of the developing kidney and affirms their potential in disease modelling and drug screening." @default.
• W2916592801 created "2019-03-02" @default.
• W2916592801 creator A5018505651 @default.
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• W2916592801 date "2019-01-23" @default.
• W2916592801 modified "2023-10-06" @default.
• W2916592801 title "Single-cell analysis reveals congruence between kidney organoids and human fetal kidney" @default.
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• W2916592801 doi "https://doi.org/10.1186/s13073-019-0615-0" @default.
• W2916592801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345028" @default.
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• W2916592801 hasPublicationYear "2019" @default.
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