Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916594759> ?p ?o ?g. }
- W2916594759 endingPage "1013" @default.
- W2916594759 startingPage "1002" @default.
- W2916594759 abstract "Insulin is a major autoantigen in type 1 diabetes, targeted by both CD8 and CD4 T cells. We studied an insulin-reactive T-cell receptor (TCR) α-chain transgenic NOD mouse on a TCRCα and proinsulin 2 (PI2)-deficient background, designated as A22Cα−/−PI2−/− NOD mice. These mice develop a low incidence of autoimmune diabetes. To test the role of gut microbiota on diabetes development in this model system, we treated the A22Cα−/−PI2−/− NOD mice with enrofloxacin, a broad-spectrum antibiotic. The treatment led to male mice developing accelerated diabetes. We found that enrofloxacin increased the frequency of the insulin-reactive CD8+ T cells and activated the cells in the Peyer’s patches and pancreatic lymph nodes, together with induction of immunological effects on the antigen-presenting cell populations. The composition of gut microbiota differed between the enrofloxacin-treated and untreated mice and also between the enrofloxacin-treated mice that developed diabetes compared with those that remained normoglycemic. Our results provide evidence that the composition of the gut microbiota is important for determining the expansion and activation of insulin-reactive CD8+ T cells." @default.
- W2916594759 created "2019-03-02" @default.
- W2916594759 creator A5001049918 @default.
- W2916594759 creator A5001969147 @default.
- W2916594759 creator A5005971145 @default.
- W2916594759 creator A5013493862 @default.
- W2916594759 creator A5022492966 @default.
- W2916594759 creator A5026334006 @default.
- W2916594759 creator A5033215847 @default.
- W2916594759 creator A5069835788 @default.
- W2916594759 creator A5090416004 @default.
- W2916594759 creator A5091015345 @default.
- W2916594759 date "2019-02-22" @default.
- W2916594759 modified "2023-10-18" @default.
- W2916594759 title "Altered Gut Microbiota Activate and Expand Insulin B15-23–Reactive CD8+ T Cells" @default.
- W2916594759 cites W1520854493 @default.
- W2916594759 cites W1595069543 @default.
- W2916594759 cites W1912307887 @default.
- W2916594759 cites W1913779731 @default.
- W2916594759 cites W1950729478 @default.
- W2916594759 cites W1964367916 @default.
- W2916594759 cites W1998603634 @default.
- W2916594759 cites W2000450805 @default.
- W2916594759 cites W2007910255 @default.
- W2916594759 cites W2014063688 @default.
- W2916594759 cites W2016073955 @default.
- W2916594759 cites W2026788361 @default.
- W2916594759 cites W2039481522 @default.
- W2916594759 cites W2041800481 @default.
- W2916594759 cites W2045119680 @default.
- W2916594759 cites W2049740824 @default.
- W2916594759 cites W2052152612 @default.
- W2916594759 cites W2056386675 @default.
- W2916594759 cites W2064671266 @default.
- W2916594759 cites W2069041713 @default.
- W2916594759 cites W2071254556 @default.
- W2916594759 cites W2086568699 @default.
- W2916594759 cites W2092894985 @default.
- W2916594759 cites W2097150236 @default.
- W2916594759 cites W2101654035 @default.
- W2916594759 cites W2102025568 @default.
- W2916594759 cites W2113799022 @default.
- W2916594759 cites W2122193107 @default.
- W2916594759 cites W2125985469 @default.
- W2916594759 cites W2126274788 @default.
- W2916594759 cites W2133693612 @default.
- W2916594759 cites W2134724359 @default.
- W2916594759 cites W2145720279 @default.
- W2916594759 cites W2148067809 @default.
- W2916594759 cites W2155827125 @default.
- W2916594759 cites W2157050207 @default.
- W2916594759 cites W2157384708 @default.
- W2916594759 cites W2293544761 @default.
- W2916594759 cites W2297529967 @default.
- W2916594759 cites W2343597029 @default.
- W2916594759 cites W2360792712 @default.
- W2916594759 cites W2370282838 @default.
- W2916594759 cites W2463036129 @default.
- W2916594759 cites W2502567773 @default.
- W2916594759 cites W2512457722 @default.
- W2916594759 cites W2519071757 @default.
- W2916594759 cites W2603850261 @default.
- W2916594759 cites W2766414693 @default.
- W2916594759 cites W340610577 @default.
- W2916594759 cites W994716540 @default.
- W2916594759 doi "https://doi.org/10.2337/db18-0487" @default.
- W2916594759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6477900" @default.
- W2916594759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30796028" @default.
- W2916594759 hasPublicationYear "2019" @default.
- W2916594759 type Work @default.
- W2916594759 sameAs 2916594759 @default.
- W2916594759 citedByCount "14" @default.
- W2916594759 countsByYear W29165947592019 @default.
- W2916594759 countsByYear W29165947592020 @default.
- W2916594759 countsByYear W29165947592021 @default.
- W2916594759 countsByYear W29165947592022 @default.
- W2916594759 countsByYear W29165947592023 @default.
- W2916594759 crossrefType "journal-article" @default.
- W2916594759 hasAuthorship W2916594759A5001049918 @default.
- W2916594759 hasAuthorship W2916594759A5001969147 @default.
- W2916594759 hasAuthorship W2916594759A5005971145 @default.
- W2916594759 hasAuthorship W2916594759A5013493862 @default.
- W2916594759 hasAuthorship W2916594759A5022492966 @default.
- W2916594759 hasAuthorship W2916594759A5026334006 @default.
- W2916594759 hasAuthorship W2916594759A5033215847 @default.
- W2916594759 hasAuthorship W2916594759A5069835788 @default.
- W2916594759 hasAuthorship W2916594759A5090416004 @default.
- W2916594759 hasAuthorship W2916594759A5091015345 @default.
- W2916594759 hasBestOaLocation W29165947591 @default.
- W2916594759 hasConcept C126322002 @default.
- W2916594759 hasConcept C134018914 @default.
- W2916594759 hasConcept C147483822 @default.
- W2916594759 hasConcept C154317977 @default.
- W2916594759 hasConcept C167672396 @default.
- W2916594759 hasConcept C202751555 @default.
- W2916594759 hasConcept C203014093 @default.
- W2916594759 hasConcept C2776090121 @default.
- W2916594759 hasConcept C2777391703 @default.